Biomedical subjects
Publications and source records attributed to W D Heath.
A glaucoma filtering procedure was performed with the YAG laser in an eye to be enucleated for malignant melanoma. Scanning electron microscopic examination shows the extent and position of the incision and the effects of the procedure on the cornea. To our knowledge, this article represents the first report of complete perforation of the sclera in a living human eye with the use of a laser alone.
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A 34-year-old man ingested more then 250 g of amodiaquine hydrochloride (for pain) during one year and was noted to have diffuse conjunctival, corneal, and skin changes and also abnormal results from retinal function tests. Ultrastructural examination of corneal and conjunctival biopsy specimens revealed intralysosomal membranous and amorphous inclusions in corneal epithelial cells, conjunctival epithelial cells, keratocytes, and vascular endothelial cells. Follow-up of more than two years and repeated conjunctival biopsy specimens revealed diminution in both the clinical and electron microscopic abnormalities, but persistence in abnormal results of retinal function tests. These changes are consistent with a drug-induced phospholipidosis.