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Biomedical subjects

W D Hiltmann

Publications and source records attributed to W D Hiltmann.

18 recordsLinked to original sources
PubMed1978

[The effects and side-effects of the intra-cervical application of prostaglandin F-2 alpha during early pregnancy (author's transl)].

In order to avoid the traumatic dilatation of the cervix for therapeutic abortions 200 micrograms of prostaglandin F-2 alpha were injected into the cervix. The effect on dilatation of the cervix was compared with the injection of normal saline in the control group. Without side effects the injection of prostaglandin F-2 alpha resulted in dilatation of the cervix and softening of the cervix. Normal saline had no effect. At present it is unknown whether the dilatory effect of prostaglandin F-2 alpha on the cervix is local or secondary to uterine contractions.

Abortion, Legal↗
PubMed1976

[Potassium substitutes during tocolysis].

The level of serum potassium during tokolytic therapy with Partusisten and Isoptin decreases in the first 24 hours of therapy. This decrease is not due to an increase in renal potassium elimination. During tokolytic treatment the serum level of potassium returns to its normal value after 48 hours without potassium substitution. While there is a decrease in serum potassium noticeable changes in electrocardiogram which are typial for hypopotassemia are observed. These changes disappear afer 48 hours of tokolytic treatment but never the less the initial serum potassium drop should be balanced by potassium substitution within these 48 hours.

Adrenergic beta-Agonists↗
PubMed1976

[Behaviour of serum concentrations of glucose, immunoreactive insulin and potassium ions in newborns after long term or crash treatments with Partusisten or Partusisten in combination with Isoptin (author's transl)].

The investigation was done on 50 infants born of metabolic healthy mothers. A group of 10 women received short term treatment with Partusisten and Isoptin. Another 10 were treated over the same period with Partusisten only. A further group of 15 received long term treatment (more than 7 days) with Partusisten and Isoptin and a final group of 15 mothers received placebos. Serum concentrations of glucose, immunoreactive insulin and potassium, together with acid-base-status and other important blood chemistry were determined in mothers and newborns directly postpartum. Blood sugar, immunoreactive insulin and potassium were further determined in the newborns 30 minutes, 60 minutes, 2 hours and 6 hours after birth. The results showed that a temporary relative hypoglycaemia occured in the newborns in short term as well as long term treatment with Partusisten or Partusisten in combination with Isoptin. Temporary derangements in insulin-glucose equilibrium were also seen in newborns from mothers receiving long term treatment. It was also demonstrated that approximately 1 hour post-partum, blood sugar and immunoreactive insulin of the newborn attained values compatible with normal carbohydrate metabolism. From these results it is indicated that infants born of mothers, who received tocolytic treatments with Partusisten or Partusisten in combination with Isoptin, should be given sodiumbicarbonate and glucose directly after birth.

Acid-Base Imbalance↗
PubMed1976

[Changes in maternal cardiovascular parameter during tocolysis and in the dorsal position shock syndrome (author's transl)].

Maternal circulatory parameters and fetal heart rate were measured in 25 healthy pregnant women in the last trimenon during treatment with Fenoterol, Fenoterol in combination with Verapamil and Verapamil alone. Dosages were used in accordance with the tocolytic guidelines from Weidinger and Wiest. We were able to demonstrate that the betamimetic Fenoterol alone and in combination with the Ca++-antagonist Verapamil strongly increases the maternal heart rate an the maternal cardiac output whereas the peripheral resistance decreases accordingly. The average blood pressure stayed leveled, so that a decreased uterine blood flow cannot be assumed under betamimetics from the maternal cardiovascular point of view. However, there are indications for an increased placental blood flow during tocolysis. The betamimetic drug show no significant effect on the fetal heart rate. Additional application of the Ca++-antagonist Verapamil during tocolysis with Fenoterol (in dosages usually used for tocolysis) doesn't change cardiovascular reactions caused by Fenoterol. Change in position from supine to left lateral position caused a short term increase in the maternal cardiac output even noted in pregnant women without a clinically observed cavasyndrom. These changes of maternal cardiac output are comparable with those in orthostatic stress situations.

Adult↗
PubMedDate not supplied

[The variability of the QRS loop in the orthogonal lead system of frank and schmitt (SVEC III) (author's transl)].

A method has been previously described, to test the accuracy of lead fields. This method is used here to compare in 7 persons the relative validity of the two orthogonal lead systems of Frank and Schmitt (SVECC III). The variables the variation of which characterizes the validity of the systems, are the spatial position (represented by the spatial angles of the normal of the broadside view) and the variations in shape of the vector loops. The latter are measured by a comparison of the length of vectors in a distance of 5 degrees, starting with the maximal vector and proceeding from here to both sides. The vectors of loops in two different heart positions are compared by means of their correlation coefficients, and one of the loops is rotated in space as long as this correlation coefficient reaches a maximum. The data are handled by a computer. The optimal correlation coefficients, the regression coefficients and the differences in the spatial angles of the planes, in which the loops show their broadside view, are compared. The Frank system has a significantly lower variability of these values, by extreme dislocations of the heart, either by respiratory or by positional dislocations.

Adult↗
PubMedDate not supplied

[Theory of methods to compare lead fields in electrocardiography (author's transl)].

A method is theoretically described to test the accuracy of various lead system of the ecg. The priniciple of this method consists in the following procedure. The heart position is changed maximally in a proband by varying the position of the body and by deep inspiration and exspiration. If the lead field is parallel, the recorded vector loops should by conventible into each other by merely rotating them electronically, because the cardiac determinants of the veg will scarcely be changed by a change in heart position. The deformations of the veg in the edgeside and broadside view are an appropriate measure of the inhomogenities (the "accuracy") of the lead field, mostly caused by the configuration of the chest and the inhomogeneous conductivity of the tissues and the resulting lack of parallelity in the lead lines of the field. Criteria to test the form of the vector loop are developed, measuring quantitatively the similarly of the loops recorded in different heart positions. The "best" lead is regarded to be that with greatest similarity of the loops in extreme dislocations of the heart.

Electrocardiography↗
PubMedDate not supplied

[Lung function during tocolysis with beta-stimulators and beta-1-blockers].

The pulmonary function during pregnancy is foremost changed by the elevated diaphragm, which reduces the functional residual capacity. The lungs are less extended, so that the airway resistance increases. The application of a beta-mimetic drug for tocolytic therapy could reduce the airway resistance. Because an additional selective beta-1-blocking drug for cardioprotection could interfere with this effect, the pulmonary function in pregnancy during tocolytic therapy was investigated by body plethysmography in 20 woman of the third trimester of gravidity. There were no apparent differences in the pulmonary function in these woman when an additional selective beta-1-receptor blockade was performed. The airway resistance even diminished during the beta blockade. This unexpected result is probably due to an stabilizing effect of the betablocker on the body fluid and the permeability of capillary membranes during tocolytic therapy.

Adrenergic beta-Agonists↗
PubMedDate not supplied

[The effect of beta-stimulation and beta-1-blockade on the motility of the upper urinary tract].

18 patients with severe congestion of the urinary tract in pregnancy were treated by implantation of ureteral catheters for intermittend exoneration. Before and during the infusion of 2 micrograms/min Fenoterol the basal tone, the frequency and amplitude of the contractions of the renal pelvis were measured after retrograde filling with increasing volumes. 45 min after the i.v. application of 10 mg Metoprolol the measurements were repeated under the same conditions. During the infusion of Fenoterol there was a significant decrease of the frequency and amplitude of the contractions of the renal pelvis. Whereas at low retrograde filling volumes the basal tone in the renal pelvis decreased, at higher filling volumes - because of the concomittant deteriation of the urine transport capacity - an increase of the basal tone could be found. The relaxant effects of the beta-stimulation on the upper urinary tract could be diminished by the application of the beta-1-blocker Metoprolol; a complete compensation however was not possible.

Adolescent↗