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Biomedical subjects

W D Hohenboken

Publications and source records attributed to W D Hohenboken.

14 recordsLinked to original sources
PubMed1992

Concentration of plasma cholesterol in beef cows and calves, milk production and calf gain.

Milk yield of 59 beef cows that calved in late September through November was measured monthly in early and late lactation and biweekly during midlactation. Milk yield was estimated by milking with a machine after over-night separation of cows from calves. Concentration of plasma cholesterol of cows and calves was measured when calves averaged 44, 93, 136, and 178 d of age (SD = 17 d). Cholesterol of calves also was measured 2 wk after weaning, when they averaged 220 +/- 2.3 d of age. Cholesterol of calves was highest at second and third samplings and dropped after weaning. The estimated intake of milkfat by calves, and to a lesser extent their intake of milk, was related positively to their plasma cholesterol as they approached weaning age. The relationship was not strong enough, however, for differences among calves in concentration of plasma cholesterol to identify accurately differences in milk yield of their dams. Within breed group, age of cow, and stage of lactation, the regression coefficients of milk yield on plasma cholesterol of cows were close to zero. The concentrations of plasma cholesterol in both cows and calves were highly repeatable, with the exception of samples that were collected when calves averaged 44 d of age. Although plasma cholesterol of calves was related positively to milk yield and milkfat yield in late lactation, the former trait was not an accurate indicator of the two latter traits.

Animals↗
PubMed1992

Prediction of fertility from calfhood traits of Angus and Simmental heifers.

The objectives of this study were to quantify the relationships between traits observed before the first breeding season and fertility of 946 Angus and 351 Simmental heifers and to use those traits to develop prediction equations for heifer fertility. Logistic regression methodology was used. Traits investigated were Julian birth date, age of the heifer's dam, birth weight, actual weaning and yearling weights, weaning and yearling weight ratios, 205-d weight, 365-d weight, and birth-weaning, weaning-yearling, and birth-yearling ADG and relative growth rate (RGR). In both breeds heifers that were younger at the start of the breeding season were less likely to conceive, but this effect was more important for Angus (logistic regression coefficient, b = -.032; P less than .01) than for Simmentals (b = -.015; P = .06). Weaning weight ratio was positively associated with heifer fertility (b = .025; P = .01 and b = .028, P = .04, respectively, for Angus and Simmental), whereas actual weaning weight was related curvilinearly to fertility of Angus heifers. The likelihood of conception was highest for Angus heifers weighing greater than or equal to 240 kg at weaning. The only postweaning trait associated with heifer fertility was weaning-yearling RGR. The likelihood of conception was highest for Angus heifers growing between .15 and .30% per day (P = .01), whereas fertility increased continuously (P = .04) for Simmental heifers as weaning-yearling RGR decreased. The maximum variations in fertility explained by models including all possible explanatory variables were 11.5 and 9.2% for Angus and Simmental, respectively. Results suggested that growth-related traits were relatively more important as a predictor of fertility for Simmental heifers and that age at the start of the breeding season was more important for Angus heifers. The combination of Julian birth date and weaning-yearling RGR produced the best models to predict heifer fertility for both breeds.

Animals↗
PubMed1991

Variation among Angus cows in response to endophyte-infected fescue seed in the diet, as related to their past calf production.

Production of 18, 12-yr-old Angus cows was summarized as the averaged weaning weight deviations of each cow's calves from their like-aged, like-sexed and similarly managed contemporaries. These cows had spent a large part of their productive lives on pastures dominated by endophyte-infected tall fescue, so differences among them in calf production might have been induced partly by differences in susceptibility to fescue toxicosis. Cows were divided randomly into two groups for a 31-d summer feeding trial. In a crossover design, cows were fed 0 or .9 kg per cow per day of endophyte-infected fescue seed. Various traits were monitored to quantify differences among cows in response to the endophyte-infected fescue seed. Baseline serum prolactin concentration was depressed by fescue seed feeding, but differences among cows in the amount of depression were not related to past calf production. Prolactin release in response to thyrotropin-releasing hormone tended to be depressed by fescue, but the response also was sensitive to factors such as ambient temperature. Serum cholesterol and body weight change did not respond significantly to the fescue challenge. The experiment was not successful in unambiguously differentiating among cows in susceptibility to fescue toxicosis or in relating differential susceptibility to past calf production.

Acremonium↗
PubMed1991

Additive and nonadditive genetic effects on milk production in dairy cattle: evidence for major individual heterosis.

Coefficients for individual and maternal breed composition and the expected contributions of individual and maternal heterosis and breed source of cytoplasm were assigned to 42,554 primiparous Holstein-Friesian, Jersey, and crossbred cows. The individual additive genetic breed effect influenced all milk production traits. Highly significant maternal additive genetic breed effects equivalent to 3% of the mean were identified for milk yield and milk fat percentage. Individual heterosis was highly significant for milk yield and milk fat yield. A primiparous first cross cow produced 6.1% more milk and 7.2% more milk fat than the average of straightbred cows of both breeds. For milk fat yield, the individual heterosis effect was higher than the individual additive genetic breed difference between Jersey and Holstein-Friesian. A small negative maternal heterosis and a small effect of breed source of cytoplasm were estimated for milk fat percentage. Results suggest that individual heterosis is a major genetic effect for milk yield and milk fat yield. This heterosis could be utilized through a stratified breeding scheme in which high genetic merit nucleus herds maintain genetic progress in the two straightbred populations, and commercial dairy herds employ a rotational cross-breeding scheme to take advantage of both the additive genetic progress and nonadditive genetic effects.

Animals↗
PubMed1989

Crossbreeding among British and continental European dual-purpose breeds in the coastal Pacific Northwest.

From 1979 through 1987, British breed and crossbred cows were mated to Simmental, Pinzgauer or Tarentaise bulls or to Hereford-Angus crossbred bulls. Beginning in 1982, continental European crossbred females also entered the herd, to be mated for first calving to Hereford-Angus or Angus bulls and as cows to continental European or Hereford-Angus bulls. In progeny of British breed and crossbred cows, dam breed effects on birth and weaning weight were not important, but continental European crossbred calves were heavier than British crossbred contemporaries at birth and weaning. Pinzgauer- and Simmental-sired calves were heavier at birth than Tarentaise crosses, but calves sired by each of the continental breeds had similar weaning weights. Maternal heterosis was greater than direct heterosis effects on weaning weight (8% vs 5%), but only direct heterosis (13%) influenced birth weight. Within progeny of continental European crossbred cows, calves with a Tarentaise maternal grandsire were lighter at birth, with no significant difference among other maternal grandsire breeds. Maternal breed effects on weaning weight were not significant. Nevertheless, in contemporary years, continental European crossbred cows reared calves that were 10% heavier than calves reared by British crossbred cows. Pacific Northwestern cattle producers could achieve substantial increases in weaning weight from introducing inheritance from continental European dual-purpose breeds into cow herds and calf crops of British ancestry.

Animals↗
PubMed1988

Genetic aspects of longevity in Angus and Hereford cows.

Thirty years and 23 yr of life history data from a Hereford herd in Arizona and an Angus herd in Wyoming, respectively, were analyzed. Longevity averaged 4.21 +/- .06 for years from first calving to disposal (FST), 7.40 +/- .06 for years from birth to disposal (AGE) and 3.46 +/- .06 for lifetime number of calves weaned (NUM) in Herefords and 4.49 +/- .13 (FST), 6.68 +/- .12 (AGE) and 3.66 +/- .11 (NUM) in Angus. In the Hereford herd, heritability estimates for traits measuring longevity, estimated from daughter-dam regression and paternal half-sib analyses, ranged from .16 to .26. In the Angus herd, heritability estimates from daughter-dam regression ranged from .03 to .05. In the Hereford herd, genetic correlations of birth weight and weaning weight with longevity, from daughter-dam regression, were negative and generally of low magnitude, whereas genetic correlations between weaning condition score and longevity were positive and moderate. Analogous estimates from paternal half-sib analyses all were positive and moderate to high. Phenotypic correlations between early life traits and longevity traits in Herefords all were near zero. In the Angus herd, curves for age-specific survivorship and age-specific survival rate varied markedly among sires. This study suggested the existence of moderate genetic variation for longevity traits in beef cattle. None of the traits expressed early in life that were examined would, however, be reliable predictors of genetic or phenotypic merit for longevity.

Animals↗
PubMed1987

Behavioral genetics.

Certain farm animal behaviors are subject partially to genetic control. This article provides examples of how knowledge of genetic differences and genetic modification of farm animal behavior might enhance both human and animal welfare. The first part of the article deals with genetic differences among species or breeds, and the second part considers differences that exist within a particular breed or population.

Animals↗
PubMed1987

Heterogeneity of sperm nuclear chromatin structure and its relationship to bull fertility.

The relationship between sperm nuclear chromatin structure and fertility was evaluated in two groups of Holstein bulls: Group 1, 49 mature bulls, and Group 2, 18 young bulls. Fertility ratings had been estimated for Group 1 and nonreturn rates were known for Group 2. Semen samples were measured by the sperm chromatin structure assay (SCSA): sperm were treated to induce partial in situ DNA denaturation, stained with acridine orange, and evaluated by flow cytometry. Acridine orange intercalated into double-stranded DNA emits green fluorescence upon excitation with 488 nm light, and red fluorescence when associated with single-stranded DNA. An index of DNA denaturation per cell is provided by alpha-t [alpha t = red/(red + green) fluorescence]. The standard deviation (SD alpha t), coefficient of variation (CV alpha t) and proportion of cells outside the main population (COMP alpha t) of the alpha t distribution quantify the extent of denaturation for a sample. Intraclass correlations of the alpha t values were high (greater than or equal to 0.70), based on four collections obtained over several years from Group 1 bulls. Negative correlations were obtained between fertility ratings and both SD alpha t (-0.58, p less than 0.01) and COMP alpha t (-0.40, p less than 0.01) in Group 1, and between nonreturn rates and both SD alpha t (-0.65, p less than 0.01) and COMP alpha t (-0.53, p less than 0.05) in Group 2. These data suggest that the SCSA will be of value for identification of low fertility sires and poor quality semen samples.

Aging↗
PubMed1987

Inheritance and interaction of immune traits in beef calves.

Three sets of blood samples were obtained from beef calves of two experimental populations and assayed for various immunological measurements. The first set of samples was taken between 24 and 48 h after birth and quantified for IgG1 concentration. A second set was taken immediately prior to vaccination for infectious bovine rhinotracheitis virus (IBRV; at an average age of 164 d) and a third set taken 60 d post-vaccination. These later samples were quantified for antibodies specific to IBRV. Level of complement C3 was also quantified in the samples taken immediately prior to vaccination. Three hundred sixty-seven calves were from four Hereford lines; three lines were previously selected for growth traits and the fourth was a randomly selected control line. There were no consistent differences in immune traits among these lines. The second group of 165 animals were Angus, Hereford and Red Poll calves. While Angus calves had a higher mean IgG1 concentration at 24 to 48 h of age than Hereford or Red Poll calves, no differences among breeds were found for the other immune traits measured. Calves from older dams (greater than 3 yr old) tended to have higher mean IgG1 concentrations, pre-vaccination IBRV antibody titers and complement C3 levels than calves from 2- and 3-yr-old cows. However, these calves had lower 60-d post-vaccination IBRV titers than calves from the younger cows (P less than .05). As pre-vaccination IBRV antibody titer increased, post-vaccination IBRV antibody titer decreased (P less than .05).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1987

Inheritance of active and acquired immunity traits in sheep.

Six hundred sixteen ewes of six strains were inoculated twice with ovalbumin in Freunds' incomplete adjuvant. To quantify the humoral immune response to the foreign antigen, blood samples were collected from all ewes 1 wk post-second injection. Blood samples were also collected between 4 and 40 h of age from their 709 lambs, to examine genetic differences in ability of lambs to acquire maternal anti-ovalbumin antibodies. Titers of anti-ovalbumin antibodies were determined using kinetic enzyme-linked immunosorbent assay (ELISA) techniques. Strain did not affect ewe immune response, but sire within strain was highly significant. In pregnant ewes, anti-ovalbumin antibody titers in 12- and 30-mo-old ewes were higher than those in 21-mo-old ewes. Number of lambs in utero did not significantly affect ewe immune response. Heritabilities of anti-ovalbumin titer from a paternal half-sib analysis were .27 +/- .17 for all ewes and .57 +/- .25 for only the pregnant ewes. The effect of strain of lamb on lamb anti-ovalbumin titer approached significance, and sire within strain was highly significant. Lamb anti-ovalbumin antibody concentration increased as time from birth to blood sampling increased to 18 h but declined thereafter. The size of the litter in which a lamb was born had a highly significant effect on the lamb's acquired immunity, with titer decreasing as litter size increased. The heritability estimate for lamb anti-ovalbumin antibody concentration from a paternal half-sib analysis was .38 +/- .11; it was .28 +/- .15 from the sire variance component of a full-sib analysis. When lamb titer was considered a maternal trait (lambs nested within their maternal grandsires within strains), the maternal grandsire variance component was negative. The average anti-ovalbumin antibody concentration of lambs that died between blood sample collection and 120 d of age was less than the average antibody concentration of lambs that survived (P less than .01).

Animals↗
PubMed1987

Production efficiency of crossbred ewes and that of their daughters and granddaughters.

Ewes of eight crossbred groups, born in 1973 and 1974, were maintained under two pasture management systems for five and four production years, respectively. After that experiment terminated, those crossbred ewes produced Polypay-sired lambs in 1979 and were then sold. Ewe lambs from those three-bred crosses were backcrossed to Polypay rams to produce lambs from 1980 to 1983. Five ancestor-descendant data sets (three involving dams and daughters and two involving granddams and granddaughters) were examined to study relationships between production efficiency of ancestor ewes and similar traits measured on their descendants. Ancestor cumulative prolificacy was positively but not significantly associated with cumulative prolificacy in the descendants. Regressions of descendant net revenue on ancestor net revenue were predominantly negative but generally were not significant. There was a tendency for prolific ancestors to produce costly but less profitable descendants. These results may be due to economic conditions (high feed costs and low lamb values) that persisted during the course of the experiment.

Animal Husbandry↗
PubMed1986

Sperm head morphology and nuclear chromatin structure evaluated by flow cytometry in a diallel cross in mice.

Genetic factors affecting spermatogenesis, sperm morphology, and chromatin structure in mice were estimated using a diallel cross of the inbred lines C3H/HeJ, C57BL/6J, DBA/2J, and BALB/cByJ. Flow cytometry of acridine orange stained cells was used to evaluate proportions of testicular tetraploid, diploid, and haploid cells and nuclear chromatin structure of sperm, measured by resistance of chromatin to in situ acid denaturation, and quantified by the ratio of double- to single-stranded DNA (alpha t). Percent morphologically abnormal sperm was scored by light microscopy. Heterosis, line, maternal, and reciprocal effects, and general and specific combining abilities were estimated for body and testis weights, testicular cell proportions, sperm alpha t values, and percent abnormal sperm. Heterosis was important for testis weight, alpha t values, and percent abnormal sperm. Inbreds varied in body and testicular weights, alpha t values, and percent abnormal sperm. Significant maternal effects were noted for several traits but could be due to sex-linked (X or Y) factors, since maternal and sex-linked effects were confounded. Although a high positive correlation existed between alpha t values and percent abnormal sperm, the proportion of sperm with altered chromatin structure, measured by FCM, was generally much lower than proportion of morphologically abnormal cells.

Animals↗