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Biomedical subjects

W D Möller

Publications and source records attributed to W D Möller.

At least 19 recordsLinked to original sources

Vascular dementia versus dementia of Alzheimer's type: do they have differential effects on caregivers' burden?

OBJECTIVES: We investigated homecare patients with dementia of Alzheimer's type (DAT; n = 36) or vascular dementia (VD; n = 36) and their care-providing relatives regarding clinical and psychosocial variables to determine whether DAT and VD impose different burdens on caregivers. METHOD: All patients were diagnosed according to ICD-10 criteria. The diagnoses were confirmed by internal medical, clinical-neurological, and psychiatric parameters. The severity of the dementias was graded according to the Global Deterioration Scale (GDS). Caregiving relatives responded to the Behavioral Pathology in Alzheimer's Disease Rating Scale (BAD), the Blessed Dementia Scale (BDS), and the Screen for Caregiver Burden (SCB). RESULTS: Analyses revealed that caregivers' burden (SCB), disease symptoms and personality changes of patients (BAD), and the patients' inability to cope with everyday tasks (BDS) were sharply higher for DAT than for VD patients in the group with severe dementia. Concerning patients with mild or moderately severe disease, scores in the DAT group were similar or lower than those in the VD group. CONCLUSION: In early stages, VD patients impose a greater burden on relatives than do patients with DAT. In severe stages this relationship undergoes a reversal, with relatives of DAT patients experiencing the burden more adversely than those of VD patients. The differences in the onset and course characteristics, as well as the specific differences between these two types of dementia with respect to caregiver burden factors, call for their diagnostic separation and the development of specific homecare support systems for family caregivers.

Activities of Daily Living↗

A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique.

Quantitative studies of the influence of anticonvulsant drugs on bone mineral content of 88 epileptics were performed by a microcomputer-aided densitometer system. The results showed that the mineral content decreases significantly with the duration of the therapy. This decrease was found to be approximately 1.2% per year for a Diphenylhydantoin (DPH) monotherapy and 1.8% per year and 2.0% per year for a DPH plus Phenobarbital and DPH plus Carbamazepin combination therapy.

Absorptiometry, Photon↗

[Large cerebral ateriovenous malformation (author's transl)].

A large cerebral arteriovenous malformation, which showed first no typical symptoms of an angioma as seizures or bleedings, but signs of a transitoric ischemic attack, is described. In computertomography there was not the angioma corresponding figure, but in angiography.

Adult↗

The dependence of cerebral blood flow on age.

Cerebral circulation time was studied with angiography of the carotid artery within a group of 45 normal cases of different age. The results showed an approximately linear increase of the circulation time with age, the coefficient of which amounts to 1% per year. For an average age of 35 years the average circulation time was determined and found to be 3.2 sec with narcosis and 4.3 sec without narcosis. This indicates that narcosis is another important parameter for the cerebral circulation.

Adolescent↗