[Health control of test bulls].
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Animals↗
Biomedical subjects
W D Müller
Publications and source records attributed to W D Müller.
Functional antagonism by a monoclonal antibody to digoxin in a test system of cultured rat heart myocytes.
A monoclonal antibody with a high affinity for digitoxin (KA = 0.50 nM) and digoxin (KA = 0.55 nM) was produced by somatic cell fusion. This antibody, designated 2A3(47), displayed little cross reactivity with other glycosides. In cultured rat heart myocytes, 2A3(47), antagonized the positive chronotropic effect exerted by digitoxin but did not alter that of ouabain. Our results suggest that this monoclonal antibody may prove to be useful in treating digoxin and digitoxin intoxication.
Animals↗
[Variance in the clinical picture and course of asphyxiating thoracic dysplasia (Jeune syndrome)].
The asphyxiating thoracic dysplasia (Jeune syndrome) is inherited as an autosomal recessive disorder. It's main characteristics are a narrow thorax with typical radiologic features resulting in respiratory problems of varying degrees. In addition typical changes of the pelvic bones and the phalanges may be demonstrated radiographically. The "major form" usually leads to respiratory failure in early infancy. If the patients survive the neonatal period they may suffer from recurrent infections of the respiratory tract. But there are also patients without respiratory problems. Renal abnormalities and renal failure are a significant feature and a hazard in later life. Patient 1, a female newborn infant with severe manifestation of the clinical and radiologic signs died from respiratory insufficiency on the 17, day of life despite of artificial ventilation. Patient 2, a now eight month old female child with typical radiologic features represents the "minor form". She had respiratory problems only during the first days of life when she required artificial ventilation and is now at a good general condition.
Asphyxia Neonatorum↗
[Idiopathic lung hemosiderosis in a 3-year-old child following ductus ligation in the neonatal period].
A premature girl (birth weight 1 405 g, gestational age 32 weeks) was mechanically ventilated for 36 days because of respiratory distress, pulmonary hemorrhage and ductus arteriosus. The hemodynamically active ductus was ligated on the 22nd day of life. At the age of three years a mycoplasma pneumonia and a pulmonary hemosiderosis developed. The possible etiologic role of the neonatal lung problems and the mycoplasma infection for the pulmonary hemosiderosis is discussed. Because a similar case has thus for not been reported the coincidence may be by chance.
Bronchopneumonia↗
[Pulmonary agenesis in partial trisomy 2 p and 21 q].
A case with bilateral cheilognathopalatoschisis, and dysplastic features agenesis of the left lung is reported. Complete absence of one lung is a very rare malformation and was due to our knowledge not reported in partial trisomy 2 p or 21 q.
Chromosomes, Human, 1-3↗
[Incidence and etiologic factors of persistent ductus arteriosus in relation to the severity of idiopathic respiratory distress syndrome].
Out of 332 patients with a confirmed diagnosis of RDS, 214 were mechanically ventilated more than 48 hours and 118 less than 48 hours. The incidence of a hemodynamically active persistent ductus arteriosus (PDA) revealed a significant difference for both groups. (54% versus 4,2%). The distribution of PDA did not seem to correlate with birthweight but rather with the severity of RDS, defined by the duration of artificial ventilation. Between three selected groups of 214 patients with longterm ventilation (1. RDS-PDA with surgical ligation - 2. RDS-PDA with spontaneous closure - 3. RDS without PDA) we found significant differences only in the values of inspiratory pressures on mechanical ventilation. No significant differences were found in the time of exposure to high levels of oxygen, the fluid balance, and the application of furosemide.
Body Weight↗
[Preoperative skin disinfection in interventions on the hip joint].
Gram-positive cocci in particular, mainly Staphylococcus aureus and Staphylococcus epidermis, can be identified on patients' skin as facultative causes of wound bed infection. Disinfection the evening prior to surgery causes a statistically significant reduction in the number of skin organisms. The only explanation of the increase in the number of such organisms in isolated patients following disinfection the evening prior to surgery, and also after preoperative disinfection, is recontamination of the disinfected skin areas. Covering them with sterile surgical trousers and adhesive foils does not provide sure protection from recontamination. Studies of this kind may enable specific hospitals to establish a perioperative antibiotic prophylaxis for their own spectrum of micro-organisms.
Bacteriological Techniques↗
Immunological analyses of Phl p V.
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Allergens↗
Antigens of Timothy and other grass pollen extracts identified by monoclonal antibodies.
Using a series of monoclonal antibodies raised against pollen extract of timothy grass pollen (Phleum pratense) we identified individual (species-specific) and cross-reactive epitopes shared by different grass and tree pollens in EIA experiments. These epitopes are heterogenously distributed as detected by means of immunoblotting. Crossed radioimmunoelectrophoresis experiments revealed binding of monoclonal antibodies to major allergens of timothy grass pollen extract.
Antibodies, Monoclonal↗