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Biomedical subjects

W D Malherbe

Publications and source records attributed to W D Malherbe.

13 recordsLinked to original sources
PubMed1977

gamma-Glutamyl transpeptidase activity in sheep serum: normal values and an evaluation of its potential for detecting liver involvement in experimental lupinosis.

A brief survey of the literature on gamma-glutamyl transpeptidase (gamma-GT) activity is included in this study. The levels of activity in the serum of normal Merino sheep (13,6-32,4 mI.U/ml) were ascertained as a preliminary to following the activity through the entire course of experimentally induced ovine lupinosis, a hepatotoxicosis caused by Phomopsis leptostromiformis (Kühn) Bubák. The response of the serum level of gamma-GT activity to the course of the disease was compared with that of glutamate oxaloacetic transaminase (GOT) and 2 liver function tests for the purpose of assessing its potential application in the study of this mycotoxicosis. Because the levels of activity of gamma-GT were more valuable for the early diagnosis of low grade acute intoxication and the detection of chronic liver involvement while those of GOT gave better information on the development of severe acute hepato-cellular damage, these 2 enzymes, considered together, were found to give the best information on the course of the toxicosis. The changes in gamma-GT activity during various stages of intoxication were also related to the histopathological lesions in the liver.

Animals↗
PubMed1976

Free flap transfer with microvascular anastomosis.

The development of the flap transfer technique in plastic and reconstructive surgery has evolved to the stage where free transplantation of a full-thickness skin flap, by means of microvascular anastomosis, has become posssible. For the first time in South Africa, a case is documented where such a free graft was used successfully to reconstruct a severe burn contracture of the neck. Experience with this and subsequent cases has taught valuable lessons about the procedure.

Adolescent↗
PubMed1976

The diagnosis and treatment of acid-base deranged dogs infected with Babesia canis.

A study was made of the acid-base status of Babesia canis infected dogs judged unlikely to recover after specific babesicidal drug therapy despite the use of blood transfusion and other conventional supportive measures. Such cases were invariably acidotic and responded well and often dramatically to supportive intravenous sodium bicarbonate administration. Elevated blood urea nitrogen, also responded gratifyingly to this procedure. The rationale is discussed in some detail.

Acidosis↗
PubMed1975

Injuries to the skin of the male external genitalia in Southern Africa.

The more common injuries to the skin of the male external genital organs are described; some of these mutilations are unique to the African continent. The extent of trauma ranges from small penile skin defects after circumcision to complete avulsion of the skin of the penis and scrotum. The techniques of reconstruction are described.

Adolescent↗