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Biomedical subjects

W D Paterson

Publications and source records attributed to W D Paterson.

At least 19 recordsLinked to original sources
PubMed1992

Blisters, ulceration and autonomic neuropathy in carpal tunnel syndrome.

We describe three patients with trophic ulceration and blistering of the fingertips associated with carpal tunnel syndrome. One of the patients also had non-insulin-dependent diabetes mellitus. Autonomic neuropathy distal to the carpal tunnel was probably present in all subjects at the time of presentation; in the patient with recent symptoms the skin was warm, and sweating was virtually absent, whilst the other two patients described cold skin, consistent with prolonged autonomic neuropathy.

Aged↗
PubMed1991

Osteochondroma of humerus in focal dermal hypoplasia (Goltz) syndrome.

Focal dermal hypoplasia (Goltz) syndrome was diagnosed in a 26-year-old female subject and her 5-year-old daughter. The mother had been treated surgically for syndactyly in early childhood, and at the age of 12 years had developed a large osteochondroma of the proximal humerus. This is a further bone tumour which should be added to the skeletal manifestations of this syndrome.

Adult↗
PubMed1991

Angioma serpiginosum: a simulator of purpura.

We describe two patients with angioma serpiginosum who had both undergone a variety of haematological tests for investigation of purpura, but in whom careful examination of the skin demonstrated abnormal blood vessels rather than extravasated blood. Recognition of vascular disorders which simulate purpura may avoid unnecessary investigations.

Adult↗
PubMed1987

Lymphomatoid papulosis/pityriasis lichenoides in two children.

Two children developed lymphomatoid papulosis/pityriasis lichenoides at ages 3 and 6 years. Follow-up continued for 13 years in the former patient and for 6 years in the latter. Both children now have continuing low-grade disease activity requiring in the one case topical corticosteroid therapy and in the other low-dose systemic steroid therapy. These children are reported to emphasize to pediatricians, pediatric pathologists, and hematologists that pseudolymphomatous conditions can exist in young children and do not require potent cytotoxic therapy. In both of our patients, the initial diagnosis was thought to be an aggressive lymphoma.

Child↗
PubMed1986

Pseudallescheriasis in northern Britain.

Five cases of Pseudallescheria boydii infection are reported from the northern part of the United Kingdom. None of the patients had travelled abroad. Three cases of otitis in which P. boydii was associated with bacterial infections were diagnosed within a 6-month period. A lady who had diabetes mellitus presented with a pulmonary fungus ball in a pre-existent cavity caused by a previous bacterial infection. After minor trauma at the site of an old skin graft, a farmer's wife developed an ulcer on the dorsum of the right ankle. Precipitating antibodies were demonstrated except in two of the cases of ear infection. The management of the individual cases is discussed.

Aged↗
PubMed1982

How important are the dermatophytes? A clinical and laboratory investigation.

Dermatophyte infections were established in 6.9% of 640 unselected dermatology outpatients attending two district general hospitals in Cumbria over a six-month period. A clinical diagnosis of ringworm was confirmed in the laboratory in 43.1% of hospital and in 21.8% of a smaller series of general practice patients. No result of similar surveys have been published before., Even in a major stock-rearing area such as this, domestic pets appear to be a more important source of infection than the farm animal.

Agricultural Workers' Diseases↗
PubMed1980

Relationships between selected strains of typical and atypical Aeromonas salmonicida, Aeromonas hydrophila, and Haemophilus piscium.

Serological analyses of typical and atypical Aeromonas salmonicida divided the representative strains into two distinguishable groups based on their antigenic composition. However, the serological groupings do not coincide with divisions constructed on the basis of physiological reactions. All of the A. salmonicida strains and the two A. hydrophila strains examined share at least one antigen and are sensitive to A. salmonicida bacteriophage 40 RR2.8t. These data reinforce the reasons for placing these two species in the genus Aeromonas. Haemophilus piscium, the causative agent of ulcer disease, was serologically indistinguishable from A. salmonicida and sensitive to A. salmonicida bacteriophages. This information, in addition to published H. piscium DNA studies, suggests this organism is actually an atypical A. salmonicida; more H. piscium isolates should be characterized to confirm this identification.

Aeromonas↗
PubMed1979

Effects of trimeprazine and trimipramine on nocturnal scratching in patients with atopic eczema.

Twelve men with severe and long-standing atopic eczema were admitted to a double-blind trial to establish the effects of trimeprazine tartrate, trimipramine maleate, and placebo on nocturnal scratching. Neither of the drugs altered the likelihood of a scratching bout beginning in wakefulness or in any stage of sleep. However, both drugs, especially trimipramine, made sleep less broken, and the reduced time spent in stage 1 of sleep accounted for a modest reduction in the overall amount of scratching during the night.

Adult↗
PubMed1978

Cellular fine structure in the invasive nodules of different histogenetic types of malignant melanoma.

Ultrastructural studies were carried out on the invasive nodule of forty malignant melanomas. The findings support the concept that the fine structure of lentigo maligna melanoma is often characteristic, and differs from that of superficial spreading and nodular melanoma. The melanosomes in lentigo maligna melanoma are usually ellipsoidal and resemble those of normal melanocytes, whereas the melanosomes in superficial spreading and nodular melanoma are most often spheroidal and abnormal in appearance. Superficial spreading and nodular melanomas cannot be distinguished reliably by their ultrastructure. Melanosomal appearances could not be related to the presence of a pre-existing naevus or the depth of invasion of the tumour nodule.

Humans↗
PubMed1978

Human malignant melanoma. Melanosomal polymorphism and the ultrastructural dopa reaction.

An ultrastructural dopa reaction, with glutaraldehyde--formaldehyde prefixation, was carried out on ten specimens of malignant melanoma showing a wide variation in melanosomal morphology. All tumours, but only a minority of tumour cells, contained reaction product. In all tumours the reaction product was distributed similarly in the Golgi apparatus and Golgi associated endoplasmic reticulum (GERL). However, differences were noted in its deposition in melanosomes. Whereas vacuolar and lamellar profiles sometimes contained reaction product, it was not seen in normal, granular and abortive melanosomes. Tumour cells without melanosomes were also seen to contain reaction product.

Dihydroxyphenylalanine↗
PubMed1976

Clinical response of dermatitis herpetiformis skin lesions to a gluten-free diet.

Patients with dermatitis herpetiformis have been studied prospectively for 2 years to assess the effect of a gluten-free diet (GFD) on control of the skin lesions. Daily requirements for oral medication with sulphapyridine or dapsone were reduced by GFD treatment and if complete clinical remission of the skin disease occurred, it was maintained while the diet was strictly observed. However, complete remission did not occur significantly more often in GFD-treated patients than in patients taking a normal diet. Many of the latter group exhibited variation in their drug dose requirements during the period of study. GFD treatment seems desirable for the majority of patients with dermatitis herpetiformis, not only to correct the intestinal abnormality but also to minimize the dose of drugs necessary to control the skin lesions.

Adolescent↗
PubMed1975

Further studies of scratching during sleep.

Fifteen patients with a variety of itching skin diseases (atopic eczema, dermatitis herpetiformis, lichen planus, urticaria and psoriasis) have been studied in the sleep laboratory. Recordings were made of all-night electroencephalogram, electro-oculogram, submental electromyogram, and muscle potentials from both forearms. Bouts of scratching during orthodox (NREM) sleep occurred more frequently in stages 1 and 2 than in stages 3 and 4. The frequency in paradoxial (REM) sleep was close to that in stage 2 sleep. This pattern was similar for all the diseases studied and seems to be related to the physiology of the sleep stages rather than to the skin diseases themselves. The mean duration of the bouts of scratching was not related to the sleep stage in which they started.

Dermatitis Herpetiformis↗