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Biomedical subjects

W D Schoppe

Publications and source records attributed to W D Schoppe.

At least 19 recordsLinked to original sources
PubMed1987

Correlation of abdominal CT imaging with autopsy findings in patients with malignant tumors.

The value of abdominal computed tomography (CT) in diagnosing localized involvement of liver, pancreas, adrenals, and lymph nodes was evaluated in 117 patients with suspected or known malignant tumors by correlation with autopsy findings. Sensitivity, specificity, and accuracy of CT for localized liver disease was calculated to be 80% (84%), 96% (97%), and 90% (92%); for pancreatic tumors: 81% (86%), 98% (100%), and 95% (97%); for adrenal tumors: 65% (92%), 100% (100%), and 92% (98%); and for lymph node enlargement 75 (88%), 97% (98%), and 87% (94%), respectively. Results of routine evaluation could be improved, especially in the adrenal region, when scans were reevaluated by highly experienced examiners (results given in parenthesis). Computed tomography is a highly valuable diagnostic tool in the primary diagnosis and in the follow-up of tumor patients. The high costs are offset by a reduction in invasive procedures and a shortened hospital stay.

Abdominal Neoplasms↗
PubMed1987

Lomustine, etoposide, vindesine, and dexamethasone (CEVD) in Hodgkin's lymphoma refractory to cyclophosphamide, vincristine, procarbazine, and prednisone (COPP) and doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD): a multicenter trial of the German Hodgkin Study Group.

Thirty-two patients with advanced Hodgkin's lymphoma resistant to cyclophosphamide, vincristine, procarbazine, and prednisone (COPP) and doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) were treated with a salvage chemotherapy regimen consisting of lomustine, etoposide, vindesine, and dexamethasone (CEVD). Twenty-seven patients were treated because of primary resistance to COPP/ABVD, and five patients were treated in early relapse (less than 12 months) after COPP/ABVD-induced complete remission. Fourteen patients (44%) achieved complete remission, and four patients achieved partial remission, with an overall response rate of 56%. Two partial responders achieved complete remission after additional radiotherapy. Four of five patients in early relapse after COPP/ABVD achieved complete remission. Consolidation radiotherapy was given for only one complete responder. Median duration of complete remission is greater than 10 months, and median survival is greater than 26 months. The treatment was well-tolerated. The main side effects were leukopenia, thrombocytopenia, mild nausea/vomiting, and cushingoid side effects. CEVD is a very active and well-tolerated salvage chemotherapy regimen in patients with Hodgkin's disease resistant to or relapsing after COPP and ABVD.

Adolescent↗
PubMed1986

[Malignant melanoma: which examinations are useful in staging and follow-up?].

Data on 378 patients with histologically proven malignant melanoma were analysed. Metastases were demonstrated within a few months to maximally 11 years postoperatively in 41 patients by clinical or biochemical examinations, computed tomography, ultrasound or radiology. At the time of the first postoperative staging examination metastases were found by clinical examination in five, by computed tomography in a further two patients. Later follow-up examinations discovered metastases by clinical examination in 32 patients, by chest X-ray in two. It is concluded that postoperative staging does not require elaborate routinely performed tests. Specific studies, admittedly undertaken only after the occurrence of symptoms, should be aimed at determining metastases and their extent so that indications for operation can be established if isolated organ metastases have been demonstrated.

Adult↗
PubMed1985

[Role of computed tomography in extrapulmonary tuberculosis].

A retrospective evaluation of 65 computed tomographic investigations on 27 patients with proven disseminated extrapulmonary tuberculosis showed no CT changes characteristic for tuberculosis, except for a higher density of tubercular abscesses. In the majority of cases the extent of tubercular manifestations could only be exactly established after the CT investigation. With the aid of this information together with the clinical course of the disease, the timing, type and extent of operative measures could be determined. Finally, in comparison with conventional X-ray and sonography, computed tomography has proved to be superior for control of therapeutic procedures.

Adult↗
PubMed1985

[X-ray image and differential diagnosis of pulmonary changes in Hodgkin's disease].

Of 291 patients with histologically confirmed lymphogranulomatosis, 45 (15.5%) with lung involvement were assessed. 22 (49%) of the patients with affected lung had the nodular sclerosing type of Hodgkin's disease. Radiologically, 15 patients showed a focal solitary manifestation of lymphogranulomatosis, whereas in 19 patients multiple, plane or circumscript areas of shadow were seen in one or both lobes of the lung. 11 further patients had unilateral or bilateral pleural effusions. Nodular (35%) and pneumonic (22%) opacities are the most frequent x-ray manifestations of pulmonary lymphogranulomatosis. The variable appearance of the lesions makes it difficult to differentiate against pulmonary infections, especially inflammatory complications, the incidence of which may be higher with these patients. In view of the far-reaching consequences, therefore, the nature of the pulmonary lesions should be clarified by biopsy in case of doubt, as early as possible (transbronchial biopsy and, if necessary, open lung biopsy).

Adult↗
PubMed1983

[Preoperative diagnosis of intra-abdominal diseases. Reliability of sonography and computer tomography].

In a retrospective study the reliability of ultrasound and computed tomography was compared and evaluated using the subsequent intraoperative findings. The analysis comprised ultrasound and computed tomography data of 111 consecutive patients in whom both investigations were performed within one week and whose diagnoses could be ascertained intraoperatively within two weeks. The correct diagnosis was made preoperatively in 80 out of 111 patients by ultrasound (sensitivity 72%) and in 95 out of 111 patients by computed tomography (sensitivity 85%). The results show that computed tomography is superior to ultrasound in preoperative diagnosis of intraabdominal diseases (P less than 0.025). In particular, liver and adrenal tumours and diseases of the air-filled gastrointestinal tract can be diagnosed more reliably preoperatively by computed tomography than by ultrasound.

Adrenal Gland Diseases↗
PubMed1982

[Computerized tomography: its validity in the diagnosis of gastroenterologic diseases (author's transl)].

The development of faster CT-machines with scantimes below five seconds and the introduction of different techniques for CT examinations (e.g. application of oral and intravenous contrast material) have influenced diagnostic procedures in medicine. On the other hand there are only a few procedures that have been replaced by CT, e. g. pneumoventriculography, pneumoretroperitoneum. In gastroenterology well established diagnostic methods as ultrasound, ERCP, PTC, barium meal and barium enema are know to have a high accuracy. CT has to be compared with these techniques and therefore its value in the diagnostic spectrum is still under investigation. So far every single method has primary or secondary indications. But it should be the aim of further studies to minimize risk and radiation dose of diagnostic procedures. Using CT this is possible, especially in intraabdominal diseases. From the present knowledge the validity of CT in the diagnosis of gastroenterologic diseases is discussed. The given recommendations might change in the future as result of ongoing investigations, technical improvements, wider distribution of CT machines and broader experiences of physicians.

Biliary Tract Diseases↗
PubMed1981

Time requirements in performing body CT studies.

In computed tomography (CT), whole body examinations take 1.5 times as long as head studies. In 73 patients (11 thoracic studies, 25 abdominal examinations, 31 CT scans of abdomen and pelvis, and 6 examinations of pelvis alone), the average time for a CT study was 136 min. The active part of the procedure lasted 60 min. Seventy-six minutes were idle time. The physician's involvement in body CT was estimated to be 53 min for an average study, when scans were taken before and after administration of contrast material. There are time differences in body CT of various anatomic regions (thorax, 40 min; abdomen, 66 min; pelvic, 52 min). The complexity of body CT, the equipment of a CT department, and the approach to diagnosis are responsible for time requirements and physician's involvement in whole body CT.

Humans↗
PubMed1980

[Estimation of organ dose during radiological and computer tomographic examinations with calculations of the somatically significant doses (author's transl)].

The risks from radiation exposure during radiological diagnosis has usually been estimated in relation to genetic changes. Relevant information has been expressed as the genetically significant dose. In this paper we attempt to produce an analogous measure for evaluating the somatic risk in the form of a somatically significant dose index for radiological and CT examinations. It is shown that, for both types of examination, the two risk factors may be entirely different.

Female↗
PubMed1977

[HB's-antigen and anti-HBs in hospital staff (author's transl)].

In 826 employees from six hospitals and three theoretical clinical institutes of Düsseldorf University HBs-antigen and anti-HBs were determined. HBs-antigen was not significantly more frequent than in a control group. On the other hand anti-HBs was much more common in hospital staff. In probands with histories of liver disease and blood transfusions there was a significantly higher incidence of anti-HBs. Different occupations within the hospitals showed different anti-HBs frequencies.

Adult↗
PubMed1977

[The effectiveness of antibiotic treatment for Salmonella enteritis and Salmonella excretors].

The role of antibiotic treatment was evaluated in 190 hospitalized patients with Salmonella enteritis and 80 with asymptomatic Salmonella infection (without typhoid or paratyphoid). The results indicate that antibiotic treatment does not shorten the duration of excretion (compared with non-treated patients). Because of the danger of prolonged bacterial excretion under antibiotic treatment in complication-free Salmonella enteritis as well as the possible development of resistant Salmonella strains, antibiotic treatment of Salmonella infections (other than typhoid or paratyphoid) should be limited to systemic forms. Treatment of complication-free Salmonella enteritis and Salmonella excretors should be limited to intestine-cleansing measures.

Acute Disease↗