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Biomedical subjects

W D Smith

Publications and source records attributed to W D Smith.

At least 19 recordsLinked to original sources
PubMed1978

A history of nitrous oxide and oxygen anaesthesia. IVC: Henry Hill Hickman in his time.

Previous verdicts on Hickman set the scene. The genealogy of Hickman and his wife is explored, disclosing the identities of "Poor Mrs Dudley of Shut End" and "Thomas Dudley of Kingswinford". Some previous evidence is explained by the bankruptcy of Hickman's father-in-law. The dubious means whereby Hickman qualified prematurely are examined.

Anesthesia, Inhalation↗
PubMed1978

A history of nitrous oxide and oxygen anaesthesia IVE: Henry Hill Hickman in his time.

More evidence is presented: a questionable letter from a grateful patient; Hickman's stewardship at a Charity Ball; the baptism of his children at Shifnal. The identities of "John" and "Glover", mentioned in Hickman's letter from Paris, and the marriage of one of Hickman's cousins to the son of a French emigré, are discussed. A recorded gift places Eliza in Paris with Henry on November 10, 1828. The need to assess the evidence in the context of its time and place is stressed.

Anesthesia, Inhalation↗
PubMed1977

Allergic dermatitis due to a triacrylate in ultraviolet cured inks.

Investigation of a dermatitis incident involving the handling of UV type inks by press minders is described. Patch tests pinpointed one acrylic component of the UV ink (pentaerythritol triacrylate) as the causal sensitizer. Factors influencing the identification and incidence of sensitization to the same chemical in different work situations are discussed as are lessons in terms of prevention under the Health and Safety at Work Act 1974.

Acrylates↗
PubMed1977

The transfer of circulating 131I IgG1 and 125I IgG2 to the nasal secretions of sheep.

Ovine IgG1 and IgG2 labelled with 131I and 125I respectively were injected intravenously into four sheep. Serum and nasal secretion samples were collected and fractionated by gel filtration on columns of Sephadex G100. Results showed that in serum more than 95 per cent of the radioactivity was associated with intact IgG molecules whereas in nasal secretion samples the percentage varied from five to 47. It was found that the concentrations of IgG1 and IgG2 in the nasal secretions were similar and were approximately 2 per cent of the serum concentrations. This finding indicates a lack of selective transfer of either IgG1 or IgG2 from blood to nasal secretions in sheep.

Animals↗
PubMed1977

Anti-larval antibodies in the serum and abomasal mucus of sheep hyperinfected with Haemonchus contortus.

A radioimmunoassay technique was used to follow the anti-larval antibody response in the serum of sheep subjected to repeated dosing with Haemonchus contortus. The response was found to develop slowly and seemed to decline as soon as the sheep stopped receiving larvae. No immunological memory was observed after the sheep were challenged with 4000 larvae nine weeks after daily dosing was stopped. Examination of abomasal mucus collected from the sheep at slaughter revealed the presence of IgA and IgG antibodies. It is suggested that most of this mucus IgG was derived from blood whereas the IgA was locally produced.

Abomasum↗
PubMed1976

The assessment in sheep of an inactivated vaccine of parainfluenza 3 virus incorporating double stranded RNA (BRL 5907) as adjuvant.

The serological responses of conventionally reared sheep were compared after vaccination with inactivated parainfluenza 3 (PI3) virus incorporated in three different adjuvants. Inactivated PI3 virus with the double-stranded RNA, BRL 5907 in an oil emulsion was shown to stimulate higher serum antibody titres over the first 5 weeks after vaccination than virus with and without BCG emulsified in oil. The ability of this vaccine to protect specific pathogen-free lambs against challenge with PI3 virus was examined in a second experiment. In this experiment the vaccine stimulated virus neutralizing and haemagglutination inhibiting antibodies in the serum. After intranasal and intratracheal inoculation with PI3 virus at challenge, vaccinated lambs showed no clinical illness and virus isolation was confined, except in one lamb, to the first two days. In contrast, unvaccinated lambs developed respiratory disease and virus was isolated daily for 7 days after challenge.

Adjuvants, Immunologic↗
PubMed1976

A comparison in mice of naloxone and nalorphine as antagonists to neuroleptanalgesic drugs.

The effectiveness of naloxone and nalorphine in antagonizing the effects of fentanyl and droperidol on the hot plate reaction time and the respiratory rate of the mouse has been compared. Naloxone was superior to nalorphine, being a more effective antagonist, and was also free from significant agonist effects. However, neither antagonist was completely effective against the respiratory rate depression produced by combinations of fentanyl and droperidol. It is suggested that the duration of the antagonist effects of naloxone are shorter against respiratory depression than against analgesia.

Animals↗