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Biomedical subjects

W D Sutliff

Publications and source records attributed to W D Sutliff.

13 recordsLinked to original sources
PubMed1983

Histoplasmosis in Veterans Administration hospitals in middle America.

A series of clinical studies of histoplasmosis based on demonstrations of etiology led to descriptions of chronic pulmonary histoplasmosis, the principal type in adults, and amphotericin B as an effective therapy. A participant recreates the atmosphere of discovery during the contributions of a team comprising a mycologist, a surgeon and two physicians using cultures of excised lung and sputum to clearly identify cases of chronic pulmonary histoplasmosis. Subsequently cooperating physicians in several V.A. Hospitals carried out randomized studies of treatment, dosage, and side effects that established Amphotericin B as the sole curative therapy for chronic pulmonary histoplasmosis for 20 years.

Amphotericin B↗
PubMed1978

Characteristics of hospitalized tuberculous patients today.

The characteristics of 149 patients with tuberculosis consecutively discharged from the Tuberculosis Service of the University of Tennessee Hospital in 1975 and 1976 were evaluated. The results of this study indicate the presence in this group of advanced age, alcohol abuse, debility from multiple chronic diseases, drug resistance, and recalcitrance. Despite the unfavorable circumstances surrounding these patients, 118 patients showed bacteriologic and/or roentgenographic evidence of improvement during an average of two to four months of hospitalization. We are not advocating the reversal of the present trend toward brief hospitalization and ambulatory care for the majority of tuberculous patients. However, as a result of this study, we believe hard-core patients of the type described in this paper require significant hospitalization for proper management.

Adult↗
PubMed1975

Experimental keratitis due to Pseudomonas aeruginosa: model for evaluation of antimicrobial drugs.

An improved method for experimental keratitis due to Pseudomonas aeruginosa is described. Essential features of the method are use of inbred guinea pigs, intracorneal injection of bacteria, subconjunctival injection of antibiotics, "blind" evaluation of results, and statistical analysis of data. Untreated ocular infections were most severe 5 to 7 days after infection. Sterilized bacterial suspensions caused no abnormalities on day 5. Tobramycin and polymyxin B were more active than gentamicin against two strains of Pseudomonas. This model is suitable for many types of quantitative studies on experimental keratitis.

Animals↗