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W D Wagner

Publications and source records attributed to W D Wagner.

At least 91 records · Page 5Linked to original sources
PubMed1975

Maximum expiratory flow-volume studies on monkeys exposed to bituminous coal dust.

To assess early ventilatory responses at the 2 mg/m3 bituminous coal dust standard, 23 cynomolgus monkeys were exposed by inhalation to Pennsylvania and Utah coal dust. Ten controls were utilized. Pennsylvania coal was selected from a field having a high prevalence of coal workers' pneumoconiosis while the Utah coal was selected from a low prevalence area. After 24 mo of exposure, a pattern of pulmonary impairment consistent with peripheral airway obstruction was demonstrated. Reductions were observed in the forced expiratory volume in 1 s, maximum midexpiratory flow rate, and especially maximum expiratory flow at small lung volumes. Hyperinflation (RV/TLC) was observed in both coal treatments; however, no specific lung volumes differed significantly from controls. No differences were found between the Pennsylvania and Utah treatments. Design and specifications for a new hydraulically operated plethysmograph-respirator are included.

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