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Biomedical subjects

W Danielczyk

Publications and source records attributed to W Danielczyk.

77 records · Page 5Linked to original sources
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Platelet monoamine oxidase B activity in dementia. A 4-year follow-up.

Platelet monoamine oxidase B (MAO-B) activity has been found to increase significantly in demented patients. For the first time, a 4-year follow-up of platelet MAO-B activity and Mini-Mental State (MMS) was performed in patients with probable dementia of the Alzheimer type (DAT) and age-matched controls. MAO-B activity of DAT patients increased significantly 2 years after the beginning of the study as compared with controls and remained significantly higher for the entire period of the examinations (p < 0.0001). The decrease of the MMS scores did not correlate with the time course of the increase of platelet MAO-B activity (Spearman rank correlation test). The decline of the MMS scores of DAT patients preceded the elevation of MAO-B activity. Since degenerative processes in brain areas which are responsible for cognitive function and are reflected by the MMS scores rather affect cerebral cholinergic than monoaminergic neurotransmitter systems, degeneration of the latter at late stages of DAT might be reflected by increased platelet MAO-B activity.

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The A-K-T ("Alters-Konzentrations-Test") a new psychometric test for geriatric patients.

The A-K-T is a newly developed concentration test for geriatric patients. First results in demented patients show the test to be a good indicator of severity of dementia. Since the method is non-verbal, it can be applied to aphatic patients too. But, comparing results of patients suffering either from dementia of Alzheimer's type, multi-infarct dementia or Parkinson's disease with dementia, we are not able to objectify specific deficits of a certain dementing disease.

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Semantic memory in DAT, MID and parkinsonism.

Previous studies found the semantic system particularly affected in Dementia of Alzheimer's Type (DAT), which would have important implications for the clinical diagnosis of this disease. We compared 14 non-demented parkinsonian patients and 14 controls on one hand and demented patients suffering from multi-infarct dementia (n = 17), DAT (n = 18) and Parkinsonism + dementia (n = 7) on the other. Demented groups were well matched regarding severity of dementia. Two tasks of semantic memory (naming, word fluency) did not differentiate within demented groups, but were correlated with severity of dementia.

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[Toxic drug effects of antiparkinson therapy and their preventability].

Parkinson's disease is an illness occurring in the third stage of life. At times, the patient suffers from arteriosclerosis as well. Reconstruction processes caused by aging are under way in the brain, which affect, among others, the synapses and transmitter substances. The biotransformation of medication may be changed in elderly persons. The tendency to multimorbidity leads to consumption of several drugs at the same time, possibly causing interference symptoms. Changes in transmitter balance and receptor excitability are, however, the main causes of the toxic side-effects of anti Parkinson therapy. The greater the nigrostriatal degeneration, the lower the tolerance level. Recently, in addition to basic therapy consisting of reduced doses of combined dopa preparations and/or Amantadine sulphate, dopaminergic agonists are used, which act on the receptors which have been maintained. This prevents some side-effects and stabilizes the patient's unpleasant daily fluctuations. Reducing the dosage prevents dyskinesia. pharmacotoxic psychoses require neuroleptics of the Thiaxanthen group or change-over to i.v. Amantadine sulphate infusions or Lisuride i.v.

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