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Biomedical subjects

W Dauch

Publications and source records attributed to W Dauch.

5 recordsLinked to original sources
PubMed1997

[Influences on the outcome of lumbar disc-surgery].

In a prospective study 30 patients suffering from a lumbar disc-prolapse and typical neurological symptoms were examined with regard to the predictors of the outcome 15 months postoperatively. Alongside the clinical examination and the raising of illness-anamnesis the Giessen pain questionnaire (Giessener Beschwerde-Bogen), the Giessen-Test, the Freiburg Personality Inventory (Freiburger Persönlichkeits-Inventar), the Mainz pain questionnaire und a pain scale were used. By means of the pain questionnaires two groups were formed. Patients without (N=15) and patients with (N=14) postoperative impairment. On the basis of selected scales of the Giessen pain questionnaire and the characteristic "psychosomatic disorder in the anamnesis" for 90% of the patients the outcome could be correctly predicted. For the estimation of the outcome by means of the estimation of global functioning level the likelihood of correct prediction was 83%. Medical and demographic parameters as well as the other results of psychological testing did not correlate with the outcome. The great importance of psychosomatic factors in a wider sense for the outcome is found to be confirmed in the literature. The significance of this result for the coping is debated with a background of the concept of "somatizing" versus "symbolizing". The conditions in therapy should lower psychological stress in order to reduce the necessity for "somatization" and facilitate "symbolization". This is specified as well for the treatment in regular surgical departments as for specialized pain-programs.

English Abstract↗
PubMed1990

[Prognosis in meningiomas. Relevance of morphologic studies and clinical risk factors].

Since the introduction of the WHO-classification of tumours of the central nervous system in 1979, meningiomas are subdivided in 8 histological types and graded I to IV. The basis for this classification were histopathological investigations combined with clinical follow-up data. Since the introduction of immunocytochemistry as a diagnostic tool in neurooncology, morphological methods have gained renewed interest among neurosurgeons and neurologists. Some of the more recent developments, as well as the classical methods of the neuropathologist, are discussed here, and the results of the impact of morphology on prognosis is discussed on 139 own cases. Beside the histopathological grading, the application of so called proliferative markers as Ki-67 and BUdR seems to be most promising in the prediction of recurrences. Clinical parameters as patients age, preoperative physical status, tumor size and location on the other hand are of particular importance concerning postoperative mortality.

Biomarkers, Tumor↗
PubMedDate not supplied

Transport and production of cerebrospinal fluid (CSF) change in aging humans under normal and diseased conditions.

In three control groups of lumbar (L), cisternal (C), and ventricular (V) cerebrospinal fluid (CSF) with prealbumin contents of ventricular origin (CSF-V-prealbumin) within the reference range, indications for an increased transport of V-CSF into spinal space are presented in the elderly as well as an elevated production of V-CSF. Indications for a diminished V-CSF production, respectively, an increased transport of CSF-V-prealbumin into the spinal space were found in elderly patients suffering from diverse CNS diseases. As these alterations proved to be not disease-specific, the age-related increase of CSF transport was discussed with respect to brain atrophy and enlarged CSF spaces in the elderly central nervous system (CNS). CSF serum prealbumin content, an indicator of blood-brain-barrier function, increased with age similarly to albumin in the "normal" elderly, respectively with diverse CNS diseases. Age- and disease-related decreases of albumin and prealbumin contents in blood serum may lead to wrong interpretations.

Adolescent↗