[Comments on the contribution by H. K. Müller-Hermelink. Pathology--possibilities and responsibilities].
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Biomedical subjects
Publications and source records attributed to W Dressler.
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Uterine plexiform tumors are morphologically distinctive lesions. Usually they are incidental microscopic findings in hysterectomy specimens that have been removed for other reasons. The rarity and the complex histomorphology of the small intramyometrial tumors may cause confusion in the diagnosis. In the reported case immunohistochemistry was performed. The results point to the disputed histogenesis that plexiform tumors are of smooth muscle origin. All plexiform tumors reported in the literature showed a benign clinical course; also in cases with intravascular extension as in intravascular leiomyomatosis.
A premature infant with terminal ileal atresia and iatrogenic bowel perforation with peritonitis developed secondary hypoganglionosis and aganglionosis of the small bowel and colon leading to loss of bowel function with fatal outcome.
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Failure of local tumor control is of critical importance in the clinical management of large pelvic tumors. For bulky sarcomas of the pelvis a new treatment strategy could be of importance in the future using preoperative regional hyperthermia combined with systemic chemotherapy. In our case history of a patient with unresectable Ewing sarcoma of the pelvis no tumor response could be observed during multi-drug chemotherapy alone. However, after treatment with regional hyperthermia combined with systemic chemotherapy, the tumor mass became resectable and was separated from the adjacent tissue by a fibrotic pseudocapsule. Histological evaluation of the tumor tissue showed a complete change of the pattern.
Breast duct obliteration and periductal elastosis were studied in 100 breast carcinomas with a maximum diameter of 20 mm or less. Seventy percent of all tumours and 90% of lobular and tubular carcinomas had obliterated ducts with radial scars at the centre of the lesion. Obesity, parity and diabetes mellitus had no apparent association with duct obliteration and periductal elastosis. The striking two peaks in age distribution suggest the presence of endocrine influences. Duct obliteration with periductal elastosis occurs where the breast shows most changes during development and involution making this the high risk zone for carcinogenesis.
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The acute gastric bleeding of children out of multifocal ulcers is an unusual leading symptom of systemic malignancy. Lymphomas of the gastrointestinal tract in children mostly are localized in the ileocoecal region and seldom in the stomach. The Zollinger-Ellison syndrome - only sporadically seen in childhood - is the first differential diagnosis. Therapy of acute ulcer bleeding consists of oversewing and medical prophylaxis of relapse and covers the directions of therapy of Zollinger-Ellison syndrome. Specific therapy of malignant lymphomas including polychemotherapy and radiation isn't possible before end of wound healing.