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Biomedical subjects

W E Bagnall

Publications and source records attributed to W E Bagnall.

9 recordsLinked to original sources
PubMed1989

The prevalence of positive serological tests for syphilis among elderly hospital patients.

Serological tests for syphilis were performed on 659 elderly patients admitted to hospital medical and psychiatric departments. Positive tests were found in 23 patients (3.5% of the sample), 17 women and 6 men. Six were subsequently discovered to have been treated previously for syphilis, and one other had radiological evidence to suggest that she had been treated with bismuth in the pre-penicillin era. Difficulties were encountered in classifying the stage of infection in some patients, particularly those with significant intellectual impairment. Eleven were diagnosed as late latent syphilis, seven as probable late latent syphilis, one as tabes dorsalis, one as possible cardiovascular syphilis, one as possible meningovascular syphilis, and one as late congenital syphilis.

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PubMed1989

Outcome of geriatric patients with lengths of stay exceeding six months (180 days).

We have studied the outcome of geriatric patients with lengths of stay exceeding 180 days. In 1985 there were 77 of these patients (37 discharges and 40 deaths) representing 2.8% of all discharges and deaths in that year. Female long stay patients survived longer than their male counterparts. Forty six per cent of patients were discharged to their own homes or local authority residential homes and 46% to private care. Elderly patients may be successfully discharged from hospital despite a protracted hospital stay.

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PubMed1988

Gonadal dysgenesis: on mature reflection!

It is unusual for disorders of sexual differentiation to be first diagnosed in old age. We describe a case of 46XY pure gonadal dysgenesis, aged 93 years at the time of diagnosis, the oldest patient with this disorder ever reported.

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PubMed1987

Deliberate falls in the elderly.

Two cases of deliberate falls in hospitalized elderly patients are reported. The falls were multiple and were the only form of self-destruction available to two disabled people. Deliberate falls are probably uncommon but should be considered in those who fall repeatedly.

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PubMed1987

Pituitary function tests in the elderly: are hypothalamic releasing factors the investigation of choice?

The use of the new hypothalamic releasing factors corticotrophin releasing factor (CRF) and growth hormone releasing factor (GHRH) has been proposed as a potential replacement for the insulin stress test in the investigation of pituitary function. The response to the injection of 100 micrograms of each compound was studied in nine elderly in-patient subjects. In response to GHRH, only four subjects demonstrated a rise in growth hormone; in response to CRF, only one subject showed a rise in cortisol. In the patients studied the combined GHRH and CRF test did not cause any cortisol or GH response in the majority.

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PubMed1979

The gastrointestinal absorption of paracetamol in the rat.

The absorption of [3H]paracetamol by rat small intestine, colon and stomach was studied in vivo and in vitro. Small intestinal in vivo studies, using a wide range of drug concentrations, showed that absorption was efficient and uniform throughout the small bowel, no site showing preferential absorption. Double reciprocal and direct plots indicated first order kinetics. The pattern was not observed when uptake was occurring from high concentrations of paracetamol in suspension. Gastric and colonic in vivo studies showed that there was appreciable absorption of [3H]paracetamol from these sites. In vitro studies using everted intestinal sacs showed no effect on paracetamol transfer when the incubation temperature was lowered to 10 degrees C or when iodoacetate (5 X 10(-2)M) and 2.4 dinitrophenol (5 X 10(-4)M) was added to the incubation medium. There was, however, a significant reduction in transfer of paracetamol against a concentration gradient of 10:1 applied across the mucosa. These data suggest that the uptake of paracetamol is by a passive transport process and confirm the efficiency of paracetamol absorption observed indirectly by others.

Acetaminophen↗
PubMed1977

Geriatric medicine in Hull: a comprehensive service.

A partially age-related admission policy coupled with a "single-ward" scheme for treatment and rehabilitation was introduced by the Hull geriatric department in 1970. With rare exceptions, elderly patients needing hospital care have been admitted directly to the geriatric unit, and the proportion of the retired population admitted by the general physicians has been greatly reduced. The proportion of inpatients needing continuing care has been reduced to less than 20%, the mean length of inpatient stay has fallen to under 30 days, and separate long-stay wards are no longer needed. More than 91% of patients are admitted without preceding domiciliary assessment, and only 5-6% of admissions are transferred from other units within the area.

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