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Biomedical subjects

W E Conner

Publications and source records attributed to W E Conner.

15 recordsLinked to original sources
PubMed2006

Tiger moth responses to a simulated bat attack: timing and duty cycle.

Many night-flying insects perform complex, aerobatic escape maneuvers when echolocating bats initiate attack. Tiger moths couple this kinematic defense with an acoustic reply to a bat's biosonar-guided assault. The jamming hypothesis for the function of these moth sounds assumes that tiger moth clicks presented at high densities, temporally locked to the terminal phase of the bat attack will produce the greatest jamming efficacy. Concomitantly, this hypothesis argues that moths warning bats of bad tasting chemicals sequestered in their tissues should call early to give the bat time to process the meaning of the warning signal and that moths calling at low duty cycles are more likely to employ such an aposematic strategy. We report here the first investigation of a tiger moth assemblage's response to playback of a bat echolocation attack sequence. This assemblage of arctiid moths first answered the echolocation attack sequence 960+/-547 ms (mean +/- s.d.) from the end of the bat attack. The assemblage reached a half-maximum response shortly after the first response, at 763+/-479 ms from the end of the terminal buzz. Tiger moth response reached a maximum at 475+/-344 ms from the end of the sequence; during the approach phase, well before the onset of the terminal buzz. In short, much of tiger moth response to bat attack occurs outside of the jamming hypotheses' predictions. Furthermore, no relationship exists between the duty cycle of a tiger moth's call (and thus the call's probability of jamming the bat) and its temporal response to bat attack. These data call into doubt the assumptions behind the jamming hypothesis as currently stated but do not directly test the functionality of arctiid sounds in disrupting echolocation in bat-moth aerial battles.

Animals↗
PubMed2005

Chemical odorant of colonial seabird repels mosquitoes.

The crested auklet, Aethia cristatella, emits a class of aldehydes shown to be potent invertebrate repellents when used by heteropterans against their predators. Our aim was to determine the efficacy of these aldehydes against mosquitoes in the laboratory. Synthetic analogues of the auklet odorant were strongly repellent to mosquitoes in controlled laboratory trials. Furthermore, the efficacy was similar to previous reports for commercial mosquito repellents. These results, in combination with a previously published study, show that constituents of the aldehyde odorant are broad spectrum in efficacy against ectoparasitic arthropods of birds. Our report is the first empirical evidence for an endogenous mosquito repellent in birds.

Aedes↗
PubMed2001

Heteropteran chemical repellents identified in the citrus odor of a seabird (crested auklet: Aethia cristatella): evolutionary convergence in chemical ecology.

The exogenous application of chemical repellents is widespread in birds, but endogenous production is exceedingly rare. We herein report a new class of avian defensive compounds isolated from the feathers and volatile odor of the crested auklet (Aethia cristatella). Mass spectra indicate that n-hexanal, n-octanal, n-decanal, Z-4-decenal and a 12-carbon unsaturated aldehyde comprise the auklet odorant. Octanal and hexanal are also secreted in the repugnant metasternal gland emissions of heteropteran insects and are known to be potent invertebrate repellents. We suggest that the auklet odorant functions as an ectoparasite repellent and a signal of mate quality. This would represent a rare and direct link between vigor, quality and parasite resistance, one of several putative bases for mate selection. This is the first report of defensive compounds produced by a seabird or colonial bird and one of the few examples of chemical defense in a polar or subpolar marine vertebrate.

Animals↗
PubMed2000

Chemical defense: bestowal of a nuptial alkaloidal garment by a male moth on its mate.

Males of the moth Cosmosoma myrodora (Arctiidae) acquire pyrrolizidine alkaloid by feeding on the excrescent fluids of certain plants (for instance, Eupatorium capillifolium). They incorporate the alkaloid systemically and as a result are protected against spiders. The males have a pair of abdominal pouches, densely packed with fine cuticular filaments, which in alkaloid-fed males are alkaloid laden. The males discharge the filaments on the female in bursts during courtship, embellishing her with alkaloid as a result. The topical investiture protects the female against spiders. Alkaloid-free filaments, from alkaloid-deprived males, convey no such protection. The males also transmit alkaloid to the female by seminal infusion. The systemic alkaloid thus received, which itself may contribute to the female's defense against spiders, is bestowed in part by the female on the eggs. Although paternal contribution to egg defense had previously been demonstrated for several arctiid moths, protective nuptial festooning of a female by its mate, such as is practiced by C. myrodora, appears to be without parallel among insects.

Animals↗
PubMed1996

Chemical egg defense in a green lacewing (Ceraeochrysa smithi)

The green lacewing Ceraeochrysa smithi (Neuroptera, Chrysopidae), like other members of its family, lays its eggs on stalks, but it is unusual in that it coats these stalks with droplets of an oily fluid. The liquid consists of a mixture of fatty acids, an ester, and a series of straight-chain aldehydes. Relative to the eggs of a congeneric chrysopid that lacks stalk fluid, the eggs of C. smithi proved well protected against ants. Components of the fluid, in an assay with a cockroach, proved potently irritant. Following emergence from the egg, C. smithi larvae imbibe the stalk fluid, thereby possibly deriving nutritive benefit, defensive advantage, or both.

Aldehydes↗
PubMed1996

Differential mobilization of fatty acids from adipose tissue.

Are the different fatty acids mobilized into plasma in proportion to their concentrations in adipose tissue triglyceride? To answer this question, we fed weaning rabbits a special diet to label the fat stores with a variety of dietary fatty acids. The release of adipose tissue fatty acids into the plasma was then induced by ACTH-stimulated lipolysis. The compositions of the resulting plasma free fatty acids and of the adipose tissue triglyceride were then compared. Plasma free fatty acids increased from 625 mumol/L at baseline to 2938 mumol/L after ACTH and represented fatty acids released from adipose tissue. The relative mobilization of these fatty acids from adipose tissue was defined as the ratio between their percentage in the plasma free fatty acid fraction to their percentage in adipose tissue triglyceride. For the 24 fatty acids examined, the relative mobilization ranged from 0.11 for 22:1 n-11 to 5.06 for 20:5 n-3, a 46-fold difference. Relative mobilization correlated positively with unsaturation and negatively with chain length. The relative mobilization for essential fatty acids was in the order of 20:5 n-3 > 20:4 n-6 > 18:3 n-3 > 22:6 n-3 > 18:2 n-6. Saturated fatty acids, along with oleic acid, were much less well mobilized than the entire group of polyunsaturated fatty acids. Our data indicate that the mobilization of fatty acids into plasma was not proportional to their content in adipose tissue, but rather was influenced by their molecular structure. Eicosapentaenoic acid 20:5 n-3 (EPA), and arachidonic acid 20:4 n-6, precursors of two different prostaglandins, were the fatty acids with the highest mobilization into the plasma.

Adipose Tissue↗
PubMed1995

Circular stapled rectal stricturoplasty with the Proximate intraluminal stapler.

PURPOSE: Benign rectal strictures arise from a variety of causes, and numerous techniques have been developed to deal with them. When even the most innovative methods of stricture treatment fail, major resection may be required. An alternative to resection is desirable. METHODS: A case is presented in which the Proximate curved intraluminal stapler was used to perform successful stricturoplasty of a low rectal stricture when other methods failed. RESULTS: Circular stapled rectal stricturoplasty provided a wide lumen, minimized perforation risk, and preserved continence. CONCLUSION: Circular stapled rectal stricturoplasty is an option to consider when other treatments for rectal stricture fail.

Aged↗
PubMed1994

Effects of dietary fat content, saturated fatty acids, and fish oil on eicosanoid production and hemostatic parameters in normal men.

Populations that consume a diet rich in marine lipids have been reported to have a lower risk of coronary heart disease. However, some Western population groups with a high fish consumption continue to suffer elevated rates of coronary heart disease. Many of these individuals consume a diet rich in saturated fats in addition to the fish. To examine these possible dietary interactions we fed six healthy men diets that contained two levels of saturated fat (5% and 19% of energy). During 3-week periods the study subjects were given diets with a low-(25% of energy) and high-(39% of energy) fat content with and without inclusion of n-3 polyunsaturated or monounsaturated fatty acids (2% of energy). The effects of the n-3 fatty acids on the principal plasma lipid fractions were similar regardless of the saturated fat intake. Platelet function, as measured by the skin bleeding time, was inhibited when n-3 fatty acids were added to the low saturated-fat diet. In vivo thromboxane A2 production as assessed by urinary metabolites also declined (p < 0.01) during supplementation with n-3 fatty acids to a low-fat diet. Prostacyclin production were reduced on a low-fat diet compared to a high-fat diet regardless of supplementation with n-3 fatty acids. N-3 fatty acids stimulated the synthesis of modest amounts of thromboxane A3 and prostacyclin I3, on both the low and high saturated-fat diets. These studies showed that the effects of eicosapentaenoic and docosahexaenoic acids on platelet and vascular function and eicosanoid production are modulated by the content of saturated fatty acids in the diet.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

Are the n-3 fatty acids from dietary fish oil deposited in the triglyceride stores of adipose tissue?

Adipose tissue is the chief reservoir of the essential fatty acids (n-3 and n-6). To study the incorporation of the dietary n-3 fatty acids eicosapentaenoic acid (EPA) (20:5) and docosahexaenoic acid (DHA) (22:6), and a unique monounsaturated fatty acid, cetoleic acid (22:1n-11), into adipose tissue, rabbits were fed two different processed fish oils: MaxEPA (high in EPA and DHA; Seven Sea Ltd, Hull, UK) and herring oil (high in cetoleic acid). EPA and DHA increased from 0% of total adipose tissue fatty acid, in the adipose tissue of control rabbits to 2.2% and 4.9%, respectively, in MaxEPA-fed rabbits. The DHA-to-EPA ratio in the adipose tissue was higher than that in the diet, indicating alternative metabolic pathways for EPA. In the adipose tissue of herring-oil-fed rabbits, cetoleic acid increased from 0% to 7.9% of total fatty acids. The deposition of EPA and DHA was 1.8% and 2.8%, respectively. Our data indicated that these unique long-chain unsaturated fatty acids from dietary fish oils were readily incorporated into the fat stores from whence they could be mobilized.

Adipose Tissue↗
PubMed1988

Magnetic resonance microscopy: in vivo sectioning of a developing insect.

The utility of magnetic resonance imaging vis-a-vis insect morphology and development was investigated. MRI is a noninvasive technique that distinguishes between tissues based on proton content and proton 'environment'. At present a resolution of 100 micron is achievable. The technique avoids fixation artifacts and allows the detection of motion within the organism.

Animals↗
PubMed1977

Benzoyl cyanide in the defensive secretion of polydesmoid millipeds.

A novel cyanogenetic compound benzoyl cyanide, was isolated from the defensive secretion of 3 polydesmoid millipeds (Pseudopolydesmus seratus, Apheloria corrugata and A. trimaculata). The secretion of the 3 species also contains mandelonitrile and benzaldehyde, and that of P. serratus contains mandelonitrile benzoate, benzoic acid, isovaleric acid, myristic acid and stearic acid.

Animals↗
PubMed1976

The transport of esterified cholesterol in plasma high density lipoproteins of human subjects: a mathematical model.

The pattern of labeling of free and esterified cholesterol in the plasma high-density lipoproteins after an intravenous injection of [3H]-mevalonic acid has been examined in six human subjects with a variety of plasma lipoprotein phenotypes. Attempts have been made to fit these data to theoretical models of high-density lipoprotein esterified cholesterol transport constructed on the basis of previous experimental observation. The first model, which assumed that the high-density lipoprotein esterified cholesterol transport constructed on the basis of previous experimental observation. The first model, which assumed that the high-density lipoprotein esterified cholesterol comprised a single homogeneous pool, was incompatible with the observed data. The second model assumed a two-pool model in which all of the plasma esterified cholesterol was produced in a small, rapidly turning over subfraction of the high-density lipoproteins. From this pool it was assumed that esterified cholesterol was transferred to other lipoprotein fractions, including transfer to a larger and much more slowly turning over subfraction of the high density lipoproteins. The second model was quite compatible with the observed data. Furthermore, the calculated net transport of esterified cholesterol through the fast turning over pool was in a range similar to that reported elsewhere for whole plasma. It has been concluded that the two-pool model not only fits the experimental data, but also accords well with previously documented observations of plasma esterified cholesterol transport.

Adult↗