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Biomedical subjects

W E Davis

Publications and source records attributed to W E Davis.

At least 19 recordsLinked to original sources
PubMed1992

Accuracy of MCMI classification of angry and psychotic black and white patients.

This study compared the ability of the MCMI personality scales to accurately predict anger and psychosis in White (n = 778) and Black (n = 272) psychiatric inpatients. Race-adjusted norms (Millon, 1984) were used to compute patients' scale scores. The MCMI successfully predicted anger and psychosis for both races (p less than .001). No difference was found in accuracy of prediction between Whites and Blacks (p greater than .40). In addition, the scales important for prediction were similar for Whites and Blacks. The Passive-Aggressive Scale best predicted anger, whereas the Avoidant Scale best predicted psychosis. The results suggest that the MCMI does predict accurately two important characteristics with both Black and White patients, but some racial bias remains.

Black or African American↗
PubMed1992

Subchronic toxicity of barium chloride dihydrate administered to rats and mice in the drinking water.

Barium Chloride dihydrate (BaCl2.2H2O) was given for 92 days to B6C3F1 mice and Fischer 344/N rats in their drinking water at levels of 0, 125, 500, 1000, 2000, and 4000 ppm. The no-effect level for this study was 2000 ppm BaCl2.2H2O in the drinking water. At 4000 ppm, daily consumption for mice was 436 to 562 mg/kg barium, up to four times more chemical than rats. Mortality ranged from 60 to 70% in mice and from 10 to 30% in rats in the 4000 ppm groups. Deaths in mice were associated with a treatment-related renal toxicity. Renal lesions in rats were much less severe than in mice and did not contribute to the treatment-related deaths seen in the high dose group. Body weights of both species and sexes in the 4000 ppm groups were lower than controls at 92 days. Male and female rats in treated groups exhibited higher serum phosphorus than controls. Serum sodium, potassium, and calcium levels in rats were unchanged by barium treatment, as were hematological values. In both species at 4000 ppm, motor activity, grip strength, and thermal sensitivity were marginally affected. These effects were probably secondary changes resulting from BaCl2 toxicity observed at this dose level. In a mating trial, no anatomical effects on offspring of rats or mice were seen. Rats receiving 4000 ppm exhibited marginal reductions in pup weights. No effects were seen on reproductive indices.

Animals↗
PubMed1992

Neurologically intact survivor of prolonged ventricular fibrillation: a case for intermediate dose epinephrine and postresuscitation infusion.

The authors point out that our understanding of the optimal dose of epinephrine used in the resuscitation of patients in cardiac arrest continues to evolve. Doses greater than the standard 1 mg of epinephrine every 5 minutes have been studied and shown to increase the rate of return of spontaneous circulation. However, reports of neurologically intact survivors of prolonged cardiac arrest are rare. The authors report a neurologically intact survivor of prolonged ventricular fibrillation with severe mixed acidosis who responded to intermediate doses of epinephrine and epinephrine infusion, where standard amounts had failed. Further research should be directed into the relationship between postresuscitation epinephrine infusions and neurologic outcome.

Epinephrine↗
PubMed1992

Anaphylaxis in immunotherapy.

Although anaphylactic reactions resulting from immunotherapy rarely occur, when they do occur they can be life-threatening. The literature reveals more than 30 deaths attributed to immunotherapy but numerous reports of anaphylaxis. We reviewed a 5-year experience of immunotherapy in a University practice and their experience with systemic reactions is presented. More than 125,000 injections were given in this time period. Of the 550 patients receiving immunotherapy, 14% experienced anaphylactic reactions, the majority of which were mild.

Anaphylaxis↗
PubMed1992

Partial endoscopic middle turbinectomy augmenting functional endoscopic sinus surgery.

Endoscopic sinus surgery has gained acceptance in the otolaryngologic community as an effective and safe method of treating inflammatory disease of the paranasal sinuses. At our institution, partial endoscopic middle turbinectomy has become a standard component of the procedure and our experience is reported. Middle turbinectomy enhances surgical exposure, specific anatomic anomalies are more completely corrected, and subpopulations of patients at risk for failure because of their underlying disease enjoy decreased rates of synechiae formation and closure of the middle meatus antrostomy when followed over time. Photodocumentation of the surgical technique and a discussion regarding the impact of middle turbinectomy on normal nasal physiology are presented. It is reported that the procedure is safe, and no complications directly attributable to middle turbinectomy (including atrophic rhinitis) are reported in a series of 298 patients.

Endoscopy↗
PubMed1991

Laryngeal airway resistance. The relationships of airflow, pressure, and aperture.

In the surgical treatment of the paralyzed larynx, a compromise often needs to be made between an orifice size needed to preserve voice and that needed for adequate inspiratory airflow rates. To assess the negative pressures needed to generate normal airflows across a narrowed vocal cord aperture, we measured pressure and flow changes across cadaveric larynges while altering aperture size. Best-fit quadratic equations for each aperture area selected were derived and showed that if the aperture were 0.5 cm2 or less, the resistance to normal breathing would be significantly increased. Aperture sizes of 0.67 cm2 or greater are not associated with such an increase in resistance.

Airway Resistance↗
PubMed1991

Assessment of schizophrenic inpatients with the MCMI.

The Million Clinical Multiaxial Inventory (MCMI) Psychotic Thinking scale previously was found insensitive in the detection of schizophrenia. The MCMI also was shown to be susceptible to undetected "faking good." We hypothesized that the insensitivity of the MCMI Psychotic Thinking scale was due to an unwillingness of schizophrenic patients to report psychotic symptoms. The MCMI was administered to 258 male schizophrenic inpatients who were classified as symptom-reporters or nonreporters based upon whether they endorsed psychotic symptoms on a separate problem checklist. Willingness to report psychotic symptoms was a significant factor in MCMI Psychotic Thinking scale scores as well as many other MCMI scales.

Adult↗
PubMed1991

Patency rate of endoscopic middle meatus antrostomy.

A series of 145 patients with chronic sinusitis were treated with functional endoscopic sinus surgery. Patency of the middle meatus was evaluated by actuarial life-table methods. After 24 months' follow-up, the overall patency rate of endoscopic middle meatotomy was 94.08%. Questionnaire data indicated that 91.8% of these patients were improved or asymptomatic. This preliminary study indicates that the patency rate of middle meatal antrostomy appears to be greater than that of inferior meatal antrostomy when compared to literature controls, and that a high percentage of these patients are improved by this surgery.

Actuarial Analysis↗
PubMed1991

Middle meatus anstrostomy: patency rates and risk factors.

Two hundred patients with chronic sinusitis were operated on using functional endoscopic sinus surgery (FESS) techniques. These patients were followed closely over 3 years. Patency of the endoscopic middle meatotomy was recorded using actuarial life-table methods. The overall patency rate of the endoscopic middle meatotomy was 93.55%, and the actuarial patency rate at 36 months was 87.47%. The presence of seasonal allergy with nasal polyps was the most important variable in predicting closure. Middle turbinectomy was the most important variable in predicting patency. Symptoms were evaluated by questionnaire at 1 year. Questionnaire data indicate that 96% of these patients are improved or asymptomatic.

Actuarial Analysis↗
PubMed1990

Test of MCMI black norms for five scales.

A 2 x 2 x 2 MANOVA was used to analyze the effects of race (Black vs. White), education (high school graduate vs. less than high school education), and diagnosis (schizophrenic vs. nonschizophrenic) on the MCMI Asocial, Avoidant, Schizotypal, Psychotic Thinking, and Psychotic Delusions scales that were obtained from 310 newly admitted psychiatric patients. The scales were selected because, according to the MCMI manual (Millon, 1983), they would be most apt to show differences between the schizophrenic and nonschizophrenic patients who participated in this study. The special norms for Black and White patients provided in the MCMI manual supplement (Millon, 1984) were used to compute the scale scores for the patients in this study. Race was the only significant (p less than .001) effect. Blacks scored higher than Whites on the Asocial, Avoidant, Psychotic Thinking, and Psychotic Delusions (p less than .04 for all scales). The results are discussed in terms of racial bias diminishing the usefulness of the MCMI.

Adult↗
PubMed1990

Age differences among psychiatric inpatients on the MCMI.

A 2 x 2 x 3 MANOVA was applied to MCMI BR scores obtained from 310 newly admitted psychiatric inpatients. The study's purpose was to test the effect of patients' age (age less than 36 vs. age greater than = 36), race (White/Black), and diagnosis (paranoid schizophrenic/nonparanoid schizophrenic/non-psychotic, nonaffectively disturbed) across MCMI personality and clinical syndrome scales. On the MCMI personality syndrome scales, age, race, and diagnosis were significant. Racial differences were consistent with recently reported research (Davis, Greenblatt, & Pochyly, 1990), but the significant differences in diagnosis were opposite the direction that might be predicted from the MCMI manual. Older patients tended to produce lower symptom scale scores than younger patients, with the most meaningful difference found on the Drug Abuse scale.

Adult↗
PubMed1990

Toxicology and carcinogenicity studies of diuretics in F344 rats and B6C3F1 mice. 1. Hydrochlorothiazide.

Toxicology and carcinogenesis studies of hydrochlorothiazide, a benzothiadiazide diuretic, were conducted by administering diets containing the drug to both sexes of F344 rats and B6C3F1 mice in 15-day, 13-week and 2-year studies. No rats died during the 15-day or 13-week studies at dietary concentrations of up to 50,000 ppm. Deaths of male mice in the top dose group in the 13-week study were likely to be related to chemical administration. In the prechronic studies, increased nephrosis and mineralization at the kidney corticomedullary junction were the primary toxic effects of hydrochlorothiazide observed in rats. In mice, chemical-related effects included nephrosis and calculi, inflammation and epithelial hyperplasia in the urinary bladder. In 2-year studies using dietary concentrations of 0, 250, 500 and 2000 ppm in rats and 0, 2500 and 5000 ppm in mice, survival of dosed and control groups of rats and mice was similar, as were body weights of mice. Dosed groups of male and female rats were uniformly lighter than controls (up to 25%) throughout the studies. Severe chronic renal disease with secondary parathyroid hyperplasia and fibrous osteodystrophy of the bone were attributed to chemical administration in rats. No neoplasms in rats or female mice or non-neoplastic lesions in mice were associated with hydrochlorothiazide. In high-dose male mice, liver neoplasms were increased but were not considered to be related to hydrochlorothiazide administration because of an unusually low incidence in the control group relative to historical controls.

Adenofibroma↗
PubMed1990

Toxicology and carcinogenicity studies of diuretics in F344 rats and B6C3F1 mice. 2. Furosemide.

Toxicology and carcinogenesis studies of furosemide, a widely used diuretic, were conducted by administering diets containing the drug to both sexes of F344 rats and B6C3F1 mice in 14-day, 13-week and 2-year studies. Deaths occurred among rats and mice receiving diets containing 46,000 ppm furosemide in 14-day studies, and animals given diets containing lower concentrations lost weight. No deaths were seen in 13-week studies using top concentrations ranging from 10,000 to 20,000 ppm, but animals at higher concentrations had lower weight gains than controls. Nephrosis in rats and mice was the only significant compound-related lesion observed in the prechronic studies. In 2-year studies, rats received diets containing 0, 350 or 700 ppm furosemide and mice received diets containing 0, 700 or 1400 ppm furosemide. Survival of dosed and control rats of both sexes and male mice was similar; survival of high-dose female mice was lower than controls. Nephropathy was increased in male rats and in male and female mice. In female mice, increased malignant tumors of the mammary gland were associated with furosemide administration. In male rats, marginal increases in tubular cell neoplasms of the kidney and in meningiomas of the brain were observed in dosed animals, but these were not considered to be related clearly to exposure to furosemide.

Adenoma↗
PubMed1990

Magnetic transcranial and electric direct stimulation of the facial motor cortex in dogs.

Magnetic stimulation may allow noninvasive study of the entire course of the facial nerve. Our goal was to determine if evoked muscle action potentials can be obtained in facial musculature using electric direct cortical and noninvasive transcranial magnetic stimulation of the canine motor cortex. Thirty-four dogs were studied with electric direct cortical stimulation through a craniotomy and magnetic transcranial stimulation of the facial motor cortex. Facial nerve stimulation in the cerebellopontine angle allowed comparison to cortical responses. Latencies of 6.08 and 9.52 msec for orbicularis oculi and levator nasolabialis, respectively, were determined with magnetic transcranial stimulation, compared with 4.22 and 5.78 msec with electric direct cortical stimulation. In conclusion, magnetic stimulation of the facial motor cortex is possible in dogs, with longer central conduction times than with electric direct stimulation.

Action Potentials↗
PubMed1990

Z-plasty.

Z-plasty is one of the oldest plastic surgery techniques. Z-plasty is a basic technique that has numerous applications in plastic surgery of the head and neck. The principles of Z-plasty are reviewed, and variations in the basic principles are explored.

Head↗