Management of seizure disorders: selected aspects. Part II.
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Biomedical subjects
Publications and source records attributed to W E Dodson.
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A fatal case of mepivacaine poisoning in a newborn infant is reported. Regional brain tissue concentrations of mepivacaine were determined by a sensitive and specific gas chromatographic-mass spectrometric method. The brain tissue levels in this patient were higher than those previously reported, possibly due to alkalosis occurring several hours prior to the infant's death.
A 10-year, 11-month-old boy who had had chronic stridor since birth died suddenly following the development of slowly progressive symptoms of respiratory obstruction due to vocal cord paralysis. Autopsy showed extensive bilateral syringobulbia, with the greatest involvement in the nuclei ambigui. Other brain-stem tracts and nuclei were only partially affected. These findings support the theory of the early developmental origin of syringobulbia.
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