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Biomedical subjects

W E Groves

Publications and source records attributed to W E Groves.

12 recordsLinked to original sources

A computerized system for rapid retrieval and compilation of critical or interesting patient data.

The timely availability and presentation of critical and interesting patient data is essential to ensure quality patient care as well as ease of recognition and, secondarily, to provide material for teaching and research. The ability to accomplish these goals expeditiously in a complex and busy clinical laboratory may be difficult to acquire. An on-line, computerized system has been developed which automatically searches each patient record for up to 600 different laboratory tests, compares each result against individually established limits, and then formats pertinent test results for maximum discrimination. The report format also includes patient and specimen collection data, diagnosis, attending physician's name, and other desired associated test results. An additional feature of the system is that selected critical or interesting results for each laboratory division may be displayed on video display terminals located throughout the laboratory and at nursing stations. The system was written using the FORTRAN programming language and runs on a Control Data Cyber 18 computer.

Clinical Laboratory Techniques

Computerized system for a nutritional support service.

The development of a computerized system for the assistance of a nutritional support service (NSS) is described. A cooperative program exists between the NSS and the Department of Laboratory Medicine, whose computer system is used to support the activities of the NSS. A record is maintained on each patient followed by the NSS (15-20 patients per day). Demographic and anthropometric data, nutritional disorder(s), laboratory data, nutritional support therapy, patient response criteria, and concomitant drug therapy are components of the computer program. Computer reports are provided to the NSS for daily rounds. An automated nutritional assessment program has also been developed. Computer assistance has proven to be a valuable tool to support the patient care, education and research program of the NSS.

Computers

A computerized system for the identification of alloimmune neutropenia in neonates.

In an attempt to determine the incidence of alloimmune neonatal neutropenia, a systematic study was initiated during a period of six months. Complete blood count, differential and absolute neutrophil count of all the newborns were determined to identify the newborns with neutropenia and those with persistent neutropenia were evaluated for the presence of maternal neutrophil antibodies. This resulted in the design and use of a computerized system which was successfully employed to identify several neonates born with this disorder. The system includes a main program and eight functional options, and is operated under a secret authority code so that patients' data are accessible only to the investigators. The major functional options are: create, display, update and delete a record for the newborn; display most recent neutropenic babies; search all records and display name and ID number; search all records for a given year and display data; and perform statistics. The statistical analysis includes the total number of babies, both normal and those with neutropenia, the total number of babies with neutropenia and with/without sepsis, and those with persistent neutropenia. Also included are the hematological data consisting of complete blood count and differential of all of the newborns. Several possibilities exist to expand and extend the program for additional research-related purposes.

Agranulocytosis

Use of a clinical laboratory computer to warn of possible drug interference with test results.

Using a clinical laboratory computer system, software has been developed which checks to determine if the result of any test performed on a patient specimen may be affected by any drug administered to that same patient. If possible interference is detected, a comment is automatically attached to the result on the patient's computer-generated report warning the attending physician the result may be falsely elevated or lowered.

Chemistry, Clinical

A dynamic computer system for the clinical laboratory.

The Clinical Laboratory Computer System currently in use at the Medical University of South Carolina is described. Not only is the existing hardware listed and shown in some detail, but also the workload, laboratory data center personnel, typical procedures, and examples of selected input and output documents are included. Particular emphasis is placed on the dynamic nature of the system, which allows the user to proceed easily in developing new programs as the requirements of the laboratory continue to change and grow. To illustrate this point, programs written by the user are described in general terms.

Computers

Amino acid coding in Sarcina lutea and Saccharomyces cerevisiae.

Aminoacyl-tRNA's from Sarcina lutea were tested for incorporation into protein in a heterologous system from Escherichia coli or for biniding in a homologous system from Sarcina lutea. Aminoacyl-tRNA's from Saccharomyces cerevisiae were tested for biniding in a homologous Saccharomyces cerevisiae system. Synthetic polyribonucleotides were used as messengers. The code which exists in Sarcina lutea and Saccharomyces cerevisiae is the same as in Escherichia coli.

Amino Acids