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Biomedical subjects

W E Jordan

Publications and source records attributed to W E Jordan.

12 recordsLinked to original sources
PubMed1986

Diaper dermatitis: frequency and severity among a general infant population.

The frequency and severity of diaper dermatitis was measured among a midwestern suburban population of 1089 infants ranging in age from 1 to 20 months. No diagnosis of specific etiology was made. Fecal samples were collected and analyzed for Candida albicans, and information on family characteristics, infant diet, general health, history of rash, and diapering habits and practices was collected by questionnaire. The distribution of the severity of observed diaper rash can be described as a logarithmic-normal function, implying several multiplicative causative factors. Within the total severity range, there appear to be three subcategories of diaper rash, differing in some manner, perhaps reflecting different etiologies. The frequency of observed diaper rash was a function of the maturity of the infant, reaching a maximum around 9 to 12 months of age. The prevalence of severe rash correlated with the presence and level of fecal C. albicans. Infants diapered exclusively in disposable diapers showed less rash (P less than 0.001) than those diapered exclusively or sometimes in cloth diapers.

Age Factors↗
PubMed1985

Adenocarcinoma of unknown primary site. The Brooke Army Medical Center experience.

A retrospective analysis of 56 tumor board records carrying the diagnosis of adenocarcinoma of unknown primary site (ACUPS) was completed. The cohort represents 1.7% of the registrations during the period from 1971-1981. The liver was the most common site from which a biopsy specimen was taken for diagnosis. The lung and pancreas were the most frequent proven primary sites. Eighteen cases went to autopsy. Primaries remained undetected in five (27%). Three of 37 patients treated with chemotherapy responded (8%). All cases to survive for longer than 24 months were well-differentiated adenocarcinomas (median survival, 6 months). The median survival of the entire cohort was 4 months. The survival difference between well-differentiated histology and less-differentiated histology was not significant (P = 0.076). The search for the primary includes investigation of the patients' signs and symptoms and limited screening tests. Treatment has not been proven to alter the natural history of ACUPS and must be weighed against toxicity.

Adenocarcinoma↗
PubMedDate not supplied

Age and diet effects on fecal bile acids in infants.

Fecal bile acid patterns and concentrations have been determined for 28 infants who were followed from average ages of 3-11 months. Half were solely breast-fed and half were solely formula-fed at the beginning of the study. Breast-fed infants were found to have significantly (p less than 0.05) lower concentrations of cholic acid than the formula-fed group, up to an average age of 5 months. Concentrations of deoxycholic and lithocholic acids were directionally lower in breast-fed infants at all ages. Concentrations of chenodeoxycholic acid were similar for both groups throughout the study. At the end of the study, breast-fed infants were excreting 17% of their total bile acids in the form of secondary acids, compared to 33% for formula-fed infants. This pattern persisted long after the infants began weaning. Formula-fed infants were found to have lithocholic acid in their stools at a significantly (p less than 0.05) earlier age than breast-fed infants. Appearance of deoxycholic acid was at similar ages for both groups. Both of these secondary acids were found to occur at much younger ages (approximately 2 months) than has been previously reported. These observed differences are attributed to the distinct intestinal microbial populations encouraged by the different diets.

Aging↗