Biomedical subjects

W E Loch

Publications and source records attributed to W E Loch.

5 recordsLinked to original sources

PubMed1991

Effects of bromocriptine and perphenazine on prolactin and progesterone concentrations in pregnant pony mares during late gestation.

Pregnant pony mares in Group A (n = 4) received i.m. injections at 07:00 and 17:00 h of 0.8 mg bromocriptine/kg body weight 0.75 per day beginning on Day 295 of gestation and continuing until parturition. Group B (n = 4) was treated similarly, but perphenazine was administered orally at 0.375 mg/kg body weight twice a day beginning on Day 305 of gestation and continuing until parturition. Mares in Group C (n = 3) received i.m. injections of saline. Mean plasma prolactin and progesterone concentrations were greater (P less than 0.05) for mares in Group C than in Groups A and B from 295 to 309 days of gestation. From 305 days of gestation, plasma prolactin and progesterone concentrations were greater (P less than 0.05) in Group B and C than in Group A mares. Progesterone and prolactin concentrations increased over this period for Group B and Group C mares, but remained constant in Group A mares. From 10 days pre partum through foaling, mares in Group A had lower progesterone (P less than 0.05) and prolactin (P less than 0.01) concentrations than Group B and C mares. All mares in Group A were agalactic at foaling, while all mares in Groups B and C had normal milk secretion. Gestation was longer (P less than 0.05) in Group A than in Group C mares. In Group A, 2 mares retained the placenta for greater than 3 h, 3 mares had dystocia and all 4 mares had thickened, haemorrhagic placentae.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1990

Tinnitus.

Sound without external stimuli may warn of serious conditions. Accurate history and physical examination along with ancillary testing, including audiograms, are essential in evaluation of these patients. Evaluation of sudden tinnitus may save hearing. Extra-auditory tinnitus may arise from respiratory, vascular, and muscular sources that are often treatable. Conductive tinnitus may indicate treatable malformation of the external or middle ear. Sensorineural tinnitus may be drug-related, noise-related, of central origin, or due to cochlear deterioration. Comprehensive diagnostic procedures can be followed by medical, surgical, psychologic, or masking therapies. All patients with tinnitus can benefit from patient education and preventive measures, and oftentimes the physician's reassurance and assistance with the psychologic aftereffects of tinnitus can be the therapy most valuable to the patient.

Humans↗

PubMed1990

Sinusitis.

Early and aggressive treatment of allergic, inflammatory, and infectious diseases of the nose and paranasal sinuses should reduce the potential for chronic and irreversible disease of the sinus mucosa. Identification of underlying allergies, reactive mucosa, impaired mucosal transport, anatomic obstruction, or narrowing are key elements in establishing an effective treatment plan and the ultimate resolution of these disease processes.

Humans↗

PubMed1987

The effects of four levels of endophyte-infected fescue seed in the diet of pregnant pony mares.

Mean weight of 20 Quarter Horse placentas on a wet basis was 3.27 +/- 0.17 kg. These placentas contained mean dry fat-free tissue, DNA, RNA and collagen weights of 411 +/- 24 g, 11.2 +/- 0.6 g, 12.4 +/- 0.7 g and 210 +/- 15 g, respectively. In Ponies and Quarter Horses, there was a trend towards a decrease in these 4 values as gestation length increased. Analysis of placentas of Ponies fed different amounts of endophyte fungus-infected fescue seed showed that weight of dry fat-free tissue increased with increasing percentages of fescue seed in the diet. Diets containing fescue seed resulted in heavier placentas containing more dry fat-free tissue, DNA, RNA and collagen than placentas from mares fed the control diet containing no fescue seed. In mares fed 45% fescue seed, 3 of the 5 foals born suffered from abnormalities: 2 died and one was saved from suffocation in the placenta. No effects of toxic tall fescue were apparent in foals from mares fed the lower levels of fescue seed (15 or 30%).

Animals↗

PubMed1978

Acute necrotizing rhinitis in man.

The clinical picture and the course of the acute necrotizing rhinitis in man is described in its different stages. Necrotizing rhinitis seems to be a significant factor in the etiology of some disturbances of the nasal respiratory function and of the ciliary activity of the nose, of atrophic rhinitis and of dry pharyngitis, in some cases of intranasai adhesions and of permanent mucosal defects of the septum. To our knowledge these defects have not been reported in the literature in the past, but are apparently not too rare.

Acute Disease↗