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Biomedical subjects

W E Stumpf

Publications and source records attributed to W E Stumpf.

At least 271 records · Page 15Linked to original sources
PubMed1969

Intracranial drug implants: an autoradiographic analysis of diffusion.

Labeled crystalline atropine, administered to the hypothlalamus of rats, remainted strictly localized in a sphere, 1.0 to 1.8 millimeters in diameter, ditring the first 3 minutes. A similar distribution obtained after 1 hour. At intermediate times, slightly elevated radioactivity, reflecting concentrations 2,000 to 10,000 times below behaviorally effective doses, was observed several millimeters from the implantation site.

Animals↗
PubMed1968

Estradiol-concentrating neurons: topography in the hypothalamus by dry-mount autoradiography.

Serial section autoradiograms were prepared of different planes of the hypothalamus and diencephalon of immature female, immature male, and ovariectomized mature rats injected with 6,7-(3)H-estradiol-17 beta. Known causes of diffusion and redistribution of the label, such as fixation, embedding, and thawing, were eliminated by the use of an autoradiographic technique based on the dry-mounting of freeze-dried sections. Neurons that concentrate estradiol exist in distinct and definable anatomical areas that are independent of the sex and hormonal state of the animals. Distribution of these neurons follows known terminations of the stria terminalis, which supports the concept of an endocrine amygdaloid-hypothalamic-hypophysial axis.

Amygdala↗