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W Edwards

Publications and source records attributed to W Edwards.

47 records · Page 3Linked to original sources
PubMed1975

Likelihood ratios as a measure of the diagnostic usefulness of excretory urogram information.

The log likelihood ratio (LLR) method of assessing physicians' diagnostic judgments can be used to measure the diagnostic usefulness of radiologic information (urography in this study). The method requires collection of referring pbysicians' diagnosis prior to and after urography and their certainty in relation to receipt of the radiologic information. Physicians in daily practice are able to provide diagnoses and assign a percentage number to their certainty. The LLR method permits measurement of the diagnostic usefulness of both normal and abnormal urogram results. Retrospective chart review does not provide the same LLR results as those obtained from the prospective study.

Adult↗
PubMedDate not supplied

Phase I trial of interferon-gamma (IFN-gamma) retroviral vector administered intratumorally to patients with metastatic melanoma.

BACKGROUND: Interferon-gamma (IFN-gamma) gene/retroviral vector cell vaccinations have generated protective responses from unmodified tumor cell challenges as well as a regression of established tumors in animal models. The purpose of this trial was to determine the feasibility and safety of a direct intratumoral injection of IFN-gamma retroviral vector in advanced melanoma patients. METHODS: This was a phase I study, in which 13 patients received a single daily injection of a retroviral vector with the IFN-gamma gene for 5 consecutive days (1.5 x 10(8) colony-forming units total dose); patients subsequently underwent resection of the injected lesion to confirm DNA transduction in situ. RESULTS: No toxicity related to the injected vector was observed. Replication competent retrovirus was not observed in any prepared samples (n = 65). IFN-gamma expression was confirmed in 3 of 10 harvested tumor samples; one was equivocal, and DNA transduction was unable to be confirmed by enzyme-linked immunospot assay in six samples. CONCLUSIONS: An injection of IFN-gamma gene/retroviral vector is well tolerated. DNA transduction was demonstrated in human subjects, confirming the feasibility of the direct injection approach for the gene therapy of solid tumors. Further trials to determine optimal schedule and potential efficacy are indicated.

Adult↗