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Biomedical subjects

W Ehrengut

Publications and source records attributed to W Ehrengut.

At least 19 recordsLinked to original sources

Bias in evaluating CNS complications following pertussis immunization.

Bias in the evaluation of CNS complications following pertussis immunization are the following: 1) Notifications of postimmunization adverse events, 2) Publications by vaccine producers on the frequency of adverse reactions, 3) Comparison of permanent brain damage after DPT and DT immunization, 4) Pro-immunization, 5) Immunization associated viral encephalitis, 6) Accuracy of statistics, 7) Personal. A review of these points indicates an underestimation of CNS complications after pertussis immunization.

Bias

[Complications after preventive mumps vaccination in West Germany (including multiple preventive vaccinations)].

Since the introduction of mumps vaccination in the Federal Republic of Germany 34 untoward vaccinal reactions were collected. In 2 cases of aseptic meningitis after mumps immunisation mumps virus was isolated from the CSF. The final investigation showed mumps virus (wild type) in one case; in the other a mumps vaccine-like strain (Jeryl-Lynn) was identified. Both patients recovered completely. These complications do not outweigh the enormous benefits of mumps immunisation.

Child

[Neural complications after diphtheria vaccination and inoculations with diphtheria toxoid-mixed vaccines. Observations on their etiopathogenesis].

In five children neural complications occurred following diphtheria immunization. In two cases, damage was related to the injection (vaccination-induced poliomyelitis), in three cases it could be traced back to a hyperergic reaction to diphtheria toxoid on the cerebral vessels. The latter complication is typical of individuals being immunized against diphtheria. Such complications are extremely rare; by no means can they question the value of active immunization against diphtheria.

Cerebrovascular Disorders

Convulsions following oral polio immunisation.

Since the introduction of oral polio vaccine in 1962, 30 cases of convulsions were registered within 30 days after the immunisation in Hamburg. 29 further cases from the surroundings came also to our attention. The majority of these cases occurred within 8 days after the vaccination (44 cases), afterwards only single cases were recorded. 33 patients were males, 24 females (2 cases sex unknown). The majority of the patients had the postvaccinal convulsions between 7 to 36 months of age, a characteristic period for febrile convulsions. 28 patients showed a course typical for febrile convulsions. In some cases intercurrent infections (pneumonia, otitis media purulenta) could also explain the nerval reactions. In 11 cases encephalopathy or encephalitis (1 case due to mumps) had been diagnoses. 8 patients suffered later from a convulsive disorder. Between 1964 and 1974 165,000 children born in Hamburg, were immunised thrice with OPV. In this period 19 convulsions and 3 permanent convulsive disorders were observed (1 case per 8,600 vaccinees; 1 convulsive disorder per 55,000 vaccinees).

Age Factors