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Biomedical subjects

W Ehrengut

Publications and source records attributed to W Ehrengut.

At least 19 recordsLinked to original sources
PubMed1997

Role of provocation poliomyelitis in vaccine-associated poliomyelitis.

The impact of different vaccine administrations in the Federal Republic of Germany, in relation to vaccine-associated paralytic poliomyelitis (VAPP) was studied. (This only means that on the basis of the temporal relation of vaccination and onset, the vaccine cannot be ruled out as possible cause). Oral polio vaccine (OPV) was given between 1963 and 1977 only and recommended simultaneously with inactivated vaccines (DT/DPT) between 1980 and 1985. In the first period 10 VAPP cases occurred among 9.96 million estimated vaccinees aged under 2 years. In the second period 6 cases of provocation poliomyelitis (PRP) were found among 2.9 million estimated OPV/DT/DPT vaccinees of the same age group. Statistically the VAPP/PRP frequencies in the two periods studied did not achieve significance.

Female↗
PubMed1991

Bias in evaluating CNS complications following pertussis immunization.

Bias in the evaluation of CNS complications following pertussis immunization are the following: 1) Notifications of postimmunization adverse events, 2) Publications by vaccine producers on the frequency of adverse reactions, 3) Comparison of permanent brain damage after DPT and DT immunization, 4) Pro-immunization, 5) Immunization associated viral encephalitis, 6) Accuracy of statistics, 7) Personal. A review of these points indicates an underestimation of CNS complications after pertussis immunization.

Bias↗
PubMed1989

[Complications after preventive mumps vaccination in West Germany (including multiple preventive vaccinations)].

Since the introduction of mumps vaccination in the Federal Republic of Germany 34 untoward vaccinal reactions were collected. In 2 cases of aseptic meningitis after mumps immunisation mumps virus was isolated from the CSF. The final investigation showed mumps virus (wild type) in one case; in the other a mumps vaccine-like strain (Jeryl-Lynn) was identified. Both patients recovered completely. These complications do not outweigh the enormous benefits of mumps immunisation.

Child↗
PubMed1986

[Neural complications after diphtheria vaccination and inoculations with diphtheria toxoid-mixed vaccines. Observations on their etiopathogenesis].

In five children neural complications occurred following diphtheria immunization. In two cases, damage was related to the injection (vaccination-induced poliomyelitis), in three cases it could be traced back to a hyperergic reaction to diphtheria toxoid on the cerebral vessels. The latter complication is typical of individuals being immunized against diphtheria. Such complications are extremely rare; by no means can they question the value of active immunization against diphtheria.

Cerebrovascular Disorders↗
PubMed1984

Prevalence of antibodies against respiratory viruses in children of Koulikoro (Mali).

The prevalence of antibodies to viruses associated with respiratory illnesses (influenza, corona, R.S., adeno, parainfluenza Mycoplasma pneumoniae) has been investigated in 119 children under 3 years of age (Koulikoro region Mali) and 50 persons 15-19 years of age (Bamako/Mali). In the surveillance period (March 1982-September 1982) an outbreak of respiratory disease in association with RS virus took place. A rise of CF titer has been found in 90.8% of the children; 59.1% of them presented a fourfold or greater increase of titer. The GMT values rose from 1:7 to 1:48. Concerning influenza viruses a higher incidence of positive reactions has been observed only for H3N2 viruses. A fourfold CF rise of titer has been observed for adenovirus and mycoplasma pneumoniae in 3 cases each, for parainfluenza type I and III in 2 cases each, and for parainfluenza II in 1 case. In persons 15-19 years of age the incidence of positive CF reactions was relatively high (68%-98%), but the GMT values were moderate (1:12-1:25). These data confirm that the frequency of viral respiratory diseases is the same in tropical countries as in countries with a temperate climate.

Adenoviruses, Human↗
PubMed1984

[Serum conversion rate following oral poliomyelitis immunization in Mali, Africa 1982].

118 infants under 3 years of age were thrice orally immunised against poliomyelitis at 2 months interval. Before the vaccination 26% were triple negative and 24% triple positive. 44% had neutralising polio antibodies type 1, 53% type 2 and 52% type 3. At the end of the vaccinations 59% of the vaccinees were triple positive and only 3.4% triple negative. 82% had polio antibodies type 1, 85% antibodies type 2 and 76% antibodies type 3. At the start of the trial 54% of the vaccinees excreted enteroviruses. Only in 12% young infants had enterovirus in anal swabs and seroconverted well. In view of the prevalence of paralytic poliomyelitis in tiny babies an early oral polio immunisation in the tropics is highly recommended.

Antibodies, Viral↗
PubMed1984

Are flaviviruses again active in Mali?

Using a hemagglutinating yellow fever antigen, a serologic investigation was done on 1237 blood samples collected between 1979 and 1983 in five regions of Mali. The results showed that the percentage of positive reactions (greater than 1:10) was higher in the sera of mothers than in their new borns (24.8 versus 12.4). In young children (6 months to 3 years old) the percentages of positive sera varied between 4.4 and 9.6. The values were much higher for persons between 15 to 70 years (28.3% to 43.7%). The presence of high antibody titers in sera of adults, the occurrence of seroconversion in young children (less than 1:10 to 1:40) are arguments for supposing that yellow fever virus or other flaviviruses were active in Mali in the period of our investigation.

Adolescent↗
PubMed1983

The reactogenicity and immunogenicity of the Urabe Am 9 live mumps vaccine and persistence of vaccine induced antibodies in healthy young children.

The immunogenicity and reactogenicity of the Urabe Am 9 mumps virus vaccine strain were studied after the administration of different doses of the vaccine to 197 children ranging in age from seven and a half months to nine years and without a history of mumps. There was no effect of dose on the response in serum neutralizing antibodies in the range of 10(2.9) to 10(4.7) TCID50/dose. In the 90 subjects without detectable serum neutralization antibodies before vaccination seroconversion was obtained in 94.4% after 42 days. Half of a group of 34 seropositive children who were tested also showed a fourfold or greater rise in antibodies. Persistence of vaccine-enhanced haemagluttinin-inhibition (EHI) antibodies was satisfactory as only two of 46 vaccinees followed-up for between 27 and 32 months had undetectable levels of EHI antibodies and the geometric mean titre of vaccine-induced EHI antibodies had only fallen to about one-third by 32 months after vaccination. Although there was serological evidence of a subclinical re-infection in three subjects, to date none of the vaccinees has had clinical mumps indicating that the vaccine confers protection against disease. The vaccine was well tolerated. Furthermore, the majority of the few 'reactions' reported were probably not vaccine-related. It is concluded that the Urabe Am 9 is an acceptable strain for use in live mumps vaccines.

Age Factors↗
PubMed1983

[Cytomegalovirus antibody titer (indirect hemagglutination) of mothers and their newborn infants from Hamburg and Bamako].

Antibodies to cytomegalovirus (CMV) have been detected by the indirect haemagglutination test in 107 paired sera (newborn and mother) from Hamburg and 39 paired sera from Bamako (Mali). In addition, 53 unpaired sera from neonates and different mothers from Mali were evaluated for our study. In Hamburg 63,5% of both newborns and their mothers possessed CMV antibodies. The GMT values of the neonatal CMV-antibody-titres was higher than in the maternal blood (1:780 versus 1:510). In Bamako the frequency of positive reactions was evidently higher: 94,9% (maternal blood) and 82,2% (newborn cord blood). The GMT value of CMV neonates antibodies was under the level registered in their mothers sera: 1:290 and 1:450 respectively. The different socioeconomic conditions of the two groups of population studied may explain the results obtained.

Antibodies, Viral↗