Effect of posture on total cortisol plasma concentration.
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Biomedical subjects
Publications and source records attributed to W Ellison.
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Here the analysis of the results of a multicentered prospective epidemiologic study that has counted only the new cases of chronic atherosclerosis obliterans of the lower extremities. Included have been 989 patients (659 men and 330 women). Critical analysis of data allows a comparative study between the sexes. Thus, specifics of arteriopathy among women can be drawn. It appears that they are only the consequences of the fact that men and women reflect a different level of tobacco use in the two populations.
The manual interpretation of identical occlusive venous plethysmography curves by different technicians is subject to a wide variation. The object of this study is to verify this state of affairs and to propose an automatic calculation of the different parameters usually used: the percentage volume increase (delta V), the time taken to half empty (t V/2) and the maximal venous outflow (MVO). We compared the variations, due to the operators, in the measurement of the parameters characterising identical curves obtained by occlusive venous plethysmography. Sixty curves from 30 patients, were photocopied and each was measured independently by four different operators. The results were compared with the measurements obtained automatically from a micro-computer connected to the plethysmograph. The measurements of the percentage volume increase and the time taken to half empty differed among the operators and the computer by less than 2%. However, the maximal venous outflow was subject to very large variations amongst the operators (up to 60%). This uncertainty is due to the operators choice of the point on the curve where the tangent is measured. The micro-computer, by fixing this point at 0.3 second after releasing the cuff allows a standardisation of this parameter.
One hundred and twenty nine in situ vein bypasses have been reviewed with a five year follow-up. Cumulative patency rates at five year are 71% (+/- 21%) for above-knee femoro-popliteal bypasses, 69% (+/- 11.5%) for below-knee anastomosis and 94% (+/- 35%) when distal anastomosis is performed on tibial or peroneal vessel. Global cumulative graft patency rate is 71% (+/- 9.4%). It is 72% (+/- 11%) in limb salvage.
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A rapid detoxification technique for heroin addicts is described. The technique uses an impulsional electric current developed by Limoge. The treatment is nonaggressive, very well tolerated by the addicts and leads to a good psychotherapeutic relationship with the medical staff. A successful physical detoxification is achieved in more than 80% of the cases (this figure is based on 400 patients treated by the method). The technique was subjected to two double-blind experiments. The first experiment tested the real efficacity of the electrical stimulation. The difference between the group of subjects stimulated and the unstimulated control group had a "p-value" which was significant at the 0,5% level. This leads us to believe that the electrical stimulation has a real positive effect. The second experiment reconfirmed the efficacity of the stimulation and showed that 24 hour continuous stimulation was not sufficient to produce a lasting effect. After about 50 hours stimulation a Naloxone test produced little or no reaction in the patients.