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Biomedical subjects

W Eppel

Publications and source records attributed to W Eppel.

67 records · Page 4Linked to original sources

[Imaging of endometrial cancer with vaginosonography].

Besides the grading parameters, another decisive criterion of prognosis for the 5 year survival rate of the endometrium carcinoma is the depth of infiltration of the carcinoma. It is possible to detect by vaginal sonography an invasion of the myometrium even in women who subjected to primary irradiation. In 8 out of 25 women the histological findings showed an adenocarcinoma type Ib, G2, where the degrees of infiltration of the myometrium that were diagnosed sonographically, varied from one-third to three-thirds. Using vaginal sonography it is possible to provide a criterion of indication for additional irradiation with telecobalt in patients undergoing primary irradiation.

Aged↗

[Effect of nicotine abuse on treatment results in primary irradiated cervical cancer].

In view of the fact that frequent occurrence of cervical carcinoma in smokers is referred in literature, the authors examined the effects of cigarette smoking on primary irradiation therapy results in cervical carcinoma. Whereas of 410 patients with cervical carcinoma of stage I and II, 260 (63.4%) attained the 5-year limit, out of 115 smokers only 62 survived (53.9%). In the advanced cases of stage III and IV, on the other hand, the rates of cure achieved in patients who were habitual smokers were significantly poorer. Of 626 non-smokers with cervical carcinoma in stages III and IV, 212 survived (33.9%), whereas of 153 smokers only 31 (20.3%) were cured (p less than 0.01). The incidence of side effects of primary irradiation was also distinctly higher in smokers than in non-smokers. Reversible complications occurred in 17.5% of the smokers and in 15.5% of the non-smokers. Severe irreversible changes occurred in 28% of smokers but in only 15.2% of the comparative group of non-smokers (p less than 0.01). The noxious effects of smoking not only impaired the biological effectiveness of ionising radiation but also increased the incidence of side effects owing to deterioration of the regenerative capacity of the tissue surrounding the tumour.

Adult↗

[Intrauterine contraception with copper-T 200 device- a retrospective analysis of 334 cases (author's transl)].

A review is given of the findings obtained in 334 women in whom a Cu-T 200 intrauterine device had been inserted at least two years previously and regular follow-up examinations were subsequently undertaken. The most frequent indications were an expressed preference for IUD on the patient's part (38.3%), poor tolerance to the "pill" (24.8%) and so-called "pill fatigue" (11.1%). Varicose veins led to IUD preference in 8.1% and thromboembolic disease in 6.-%. The failure rate - with 12 pregnancies - was 3.6%, all within 6 months of insertion of the device. Half of the pregnancies went to full term and resulted in the birth of mature, healthy babies. The most frequent complication were menstrual disturbances (20.1%). pain (19.5%), cervicitis (18.3%), and adnexitis (13.8%), necessitating removal of the device in 5.7%, 4.2%, 5.1%, and 0.6% of all cases for the afore-mentioned reasons, respectively. These rates are relatively high. The expulsion rate of 2.7% was relatively low, however. Further analysis of the complications led to the observation that menorrhagia was relatively common in nulliparae and in women with retroversion of the uterus, whereas the pre-insertion finding of a pressure-sensitive uterus with a normal ESR, led in a significantly higher percentage of cases to pain and adnexitis. The diagnosis by vaginal probe of a reduced uterine length led to faulty positioning and an increased tendency to pain in a significantly higher number of cases. The fact that only 56.6% of all women tolerated intrauterine contraception well and remained totally symptom-free supports th view held by us that even today the "pill" remains the contraceptive of choice and should be recommended as such.

Female↗

[Contraception in preclimacteric women with special regard to oral contraceptives (author's transl)].

During a period of 9 years 143 women at an age over 40 attended for the first time the I. University Clinic of Gynecology and Obstetrics in Vienna for receiving contraceptive treatment. 71 women (49.6%) received oral contraceptives wiD was inplanted because of either internal contraindications of oral contraceptives (mainly high risk for thrombosis) or negation by the patient. 16 patients were sterilised, mostly with the laparascope. The main side effects in the patients receiving oral contraceptives were nervosity, impairment of libido and complaints in the lower extremities. 60.5% of all women over the age of 40 using oral contraception didn't show any complaints. On the basis of the own results and the reports in literature the advantages and disadvantages of oral contraception in comparison with mechanical devices are discussed.

Adult↗

[Umbilical blood flow indices in smoking women].

A collective of 154 pregnant women, who smoked at least 5 cigarettes a day was examined by doppler ultrasound. Measurements were taken at the two ends of the umbilical cord. The results had been compared to the physiological constellation of the resistance indices. Elevation of the PI was mainly to be registrated at the fetal abdominal insertion of the umbilical vessels. It seems to be dependent on the duration and amount of smoking. There was no correlation to be found to the fetal outcome.

Blood Flow Velocity↗

[Vaginal ultrasound in puerperium. Cervix and lower uterine segment on the 1st p. p. day and uterus 6 weeks post partum].

In this study it was tried to demonstrate the involution of the puerperal uterus vaginosonographically. A collective of 54 patients with uncomplicated delivery and afebrile, inconspicuous puerperium was vaginosonographically examined on the 1st day postpartum and also 6 weeks post partum. To describe the uterus in its whole entity on the 1st day post partum an abdominal sonography was carried out too. The vaginosonographic examinations showed on the 1st day post partum an average cervical length of 40.7 +/- 8.4 mm, a width of 31.2 +/- 4.0 mm and an internal os of 5.6 +/- 3.0 mm. The width of the lower uterine segment was 15.7 +/- 7.7 mm. The control examination after 6 weeks result in a cervical length of 31.2 +/- 4.0 mm, a width of 28.2 +/- 3.9 mm and an internal os of 3.1 +/- 1.1 mm. The reformation of cervix occurs rapidly and can be seen even on the first day post partum.

Adult↗

[Effects of prostaglandin E1 analogs on the cervix--observations with vaginal sonography].

In this study participated 17 patients, in whose pregnancies not viable malformations or intrauterine deaths were diagnosed. The termination of the pregnancies was done with PG-E-1 suppositories Gemeprost (Cergem) 1 mg. Collectively the patients received 3 Cergem suppositories applicated all 3 hours. Before beginning therapy and every 4-6 hours a vaginosonography was done. The cervical changes under the influence of Gemeprost were documented vaginosonographically. The measurements before Gemeprost treatment showed an average cervical length of 44.2 +/- 6.3 mm, a width of 29.5 +/- 1.7 mm and an internal os of 2.5 +/- 0.5 mm. The results of the second ultrasound showed a length of 30.6 +/- 4.1 mm, a width of 32.3 +/- 2.5 mm and an internal os of 7.0 +/- 3.0 mm. The last measurements (ca. 107 minutes before abortion) showed a remaining of cervical length of 15.2 +/- 4.5 mm, a width of 41.5 +/- 4.6 mm, an internal os of 19.2 +/- 4.1 mm and the amniotic membranes bulged into the cervical channel.

Abortifacient Agents, Nonsteroidal↗

[Imaging of premature uterine contraction in vaginal sonography].

A collective of 60 patients with clinical diagnosed contractions was vaginosonographically examined. During the ultrasound examination preterm labour was seen in 42 patients. In a control group (n = 50) preterm contractions were not detectable. The average time of the contractions was 88 seconds in the primipara group and 90 seconds in the multipara group and showed no statistical significance. In the group of the primipara a shortening of the cervical length of 17 (+/- 6) mm, in the multipara group 15 (+/- 5) mm was seen under contractions, furthermore a thickening of 8 +/- 4 mm respectively 10 +/- 5 mm. The internal os of the primipara opened 11 +/- 6 mm, of the multipara group 13 +/- 6 mm. The highest incidence of uterine contractions was found in the 32nd week. The paired students t-test showed a significance of p less than 0.001 for the cervical length, thickness and internal os and for the thinning of the dorsal uterine wall, subdividing the parity did not show statistical significance. The vaginosonography is able to help detecting preterm labour.

Adult↗

[The cervix at term--an ultrasonographic study].

Transvaginal sonography with a 5 MHZ probe was used to measure the cervical length, width and the internal os. We examined 37 Primiparae (group 1) and 36 Multiparae (group 2) in the 40th and 41st gestational week vagino-sonographically. All pregnancies were uncomplicated. For comparison between the datas of shortening and thickening of cervix the students t-test showed a significance of p less than 0.05. We registered vagino-sonographically that under painless uterine contractions the cervix shortened with an increase of thickness, while the internal os was constant and opened at least. A reformation of cervix in the relaxation phases was seen.

Adult↗

[Dynamic measurement of surface tension versus gas chromatography dipalmitoylphosphatidylcholine analysis of amniotic fluid; a comparison of a bedside method with a highly specialized surfactant analysis].

The diagnosis of fetal lung maturity by analysis of the amniotic fluid still constitutes a present-day problem. In this study the results of measuring the dynamic surface tension by the Wilhelmy-balance were compared with the DPPC (Dipalmitoyl-Phosphatidyl-Choline) and lecithin species-analysis by the quantitative capillary gas chromatography. The first possibility is a "bed-side"-method, which evaluates the effect of the surfactant in the amniotic fluid in its entirety, whereas the second method represents a highly specialized laboratory procedure analysing the most important part of surfactant contact. The surface tension of amniotic fluid is expressed by its value at 20% of the extension of the surface (gamma-min) as well as the hysteresis area. We were able to show a better correlation between the hysteresis area and the DPPC (r = 0.422, p less than 0.012) than between the gamma min and the DPPC (r = 0.370, p less than 0.031). The correlation between the hysteresis area respectively between the gamma-min, and the second gas chromatographically detectable component of the surfactant, PC 30 was not so distinct (r = 0.068, p less than 0.744; R = -0.355, p less than 0.075). Obviously this component of the surfactant is not as active on the surface and therefore not as important. Further we could show, a negative correlation to the lecithin species PC 34; with increasing surface activity and increasing lung maturity this lecithin species quantitatively recedes into the background.

1,2-Dipalmitoylphosphatidylcholine↗

[Effect of low birth weight on menstruation and sex behavior in adulthood].

We report the results of a follow-up study of women, who had low birth weight, and their later gynecological development concerning menarche, menstrual cycle, menstrual complaints, sexual activity and fertility. 50 women with a mean age of 22 years have been divided into three groups (13 women had a birth weight below 1.500 g, 17 women were within the range of 1.500 g and 2.000 g and 20 women between 2.001 and 2.500 g). Considering the parameters menarche, sexual activity and fertility no differences among those three groups were found. Comparing all three groups of low-birth-weight newborns significant differences could be shown in menstrual cycle and menstrual complaints.

Adolescent↗

[Role of the cervix uteri at labor onset from ultrasound studies].

The cervix uteri is of greatest importance for the environment of the fetus. The sonographic imaging of the cervix uteri can be done by transabdominal, perineal and transvaginal route. Each of these methods are associated with specific advantages and disadvantages. During the time of gestation the cervix uteri can be measured sonographically concerning the length, the thickness, the width of the cervical canal and in addition the diameter of the internal and the external os. At the beginning of labour the cervix shows a transformation: a shortening with an increase of thickness. The phase of contraction is followed by a phase of reformation. Individual formations of the cervix regarding the a premature opening of the internal os or the external os could be demonstrable without clinical symptoms. By W. Eppel a score-like formula "Incompetence-Factor" was described for a quantification of these measurements.

Cervix Uteri↗