Biomedical subjects

W Ergete

Publications and source records attributed to W Ergete.

8 recordsLinked to original sources

PubMed2005

Staple Ethiopian diet and cancer of the oesophagus.

BACKGROUND: Previous reports from Ethiopia suggest that oesophageal cancers are due to thermal injury of hot food and beverages. However, in most other countries diet plays an important role. OBJECTIVES: To investigate the association of diet and incidence of carcinoma of oesophagus in Ethiopia. DESIGN: A prospective study. SETTING: All adult patients, who were either referred or self referred from other health institutions, were investigated in Mexico Higher Clinic, Addis Ababa, Ethiopia. SUBJECTS: All patients who presented for endoscopy for the duration of one year, February 1st to January 2002, were included in the study. RESULTS: There were 902 adult patients of whom 596 (66%) were male and 306 (34%) were female. The age range was 16 to 81 with a mean of 37 and the male to female ratio was 1.95:1. Christians out-numbered Muslims. There were more merchants than office workers or peasants. Those who came from Addis Ababa were 600 (66%) and the rural patients were 302 (34%). The ethnic groupings indicated Amhara, Gurage and Oromo to be the predominant ones. Six hundred sixty two patients ate tef, 140 ate wheat and 100 ate kocho (Qocho). There were 27 specimens, which had malignant cells. Thirteen specimens failed to show malignant cells. Thirteen (13%) Qocho eaters had cancer of oesophagus, nine (6.5%) wheat eaters had cancer and only five of tef eaters (0.70%) were affected. Dysphagia was the single most common symptom with which patients presented in cases of cancer of oesophagus. Cancer of oesophagus was located in upper, middle and EG junctional area in 5, 12 and 10 patients respectively. There were 16 cases of squamous cells and 11 cases of adenocarcinoma of a total of 40 specimen taken. Thirteen specimens failed to show malignant cells. CONCLUSION: Kocho (Qocho) eating appearsto be associated with developing cancer of the oesophagus.

Adolescent↗

PubMed2003

Histopathologic pattern of thyroid disease.

BACKGROUND: Diseases of the thyroid are manifested by alteration in hormone secretion, enlargement of the thyroid gland (goiter), or both. The principal diseases of the thyroid gland are goiter (diffuse or nodular), hypo or hyperthyroidism, thyroiditis and neoplasms. The incidence and prevalence of these thyroid diseases in a given community are variable depending on various factors. Simple (non-toxic) goiter is extremely common throughout the world and is most prevalent in mountainous areas. The reported prevalance of goiter in Ethiopia varies between 18% and 30%. OBJECTIVE: To review the histopathologic patterns of thyroid disease and their relationship with age and sex over a five year period. SETTING: Tikur Anbessa teaching and referral hospital, Department of Pathology, Faculty of Medicine, Addis Ababa University. METHODS: Retrospective analysis of five years biopsy material from patients with thyroid disease. RESULTS: Seven hundred and eighty consecutive patients with thyroid disease were included in the study. Six hundred and sixty (79%) were found to be non-neoplastic and 164 (21%) were neoplastic. Nodular colloid goiter (NCG) were found in 600 (76.9%) cases. Adenoma, carcinoma and thyroiditis accounted for 100 (12.8%), 64 (8.2%) and 16 (2.1%) cases respectively. Female to male ratio was 4.5:1. Eighty five point seven per cent of the thyroid diseases were found in the age group 20-59 years. CONCLUSION: Nodular colloid goiter is the most prevalent thyroid disease. Papillary carcinoma is the most frequent cancer seen in this series. Appropriate measures should be taken to reduce the iodine deficiency states in the diet to alleviate the social and medical consequences of the NCG. Similary clinical evaluation of goiter should be thorough, and use all means especially histopathologic study of the specimens to arrive at a definitive diagnosis as thyroid carcinoma is not uncommon.

Adolescent↗

PubMed2001

Rhinocerebral mucormycosis in an 11-year-old boy.

A patient with diabetic ketoacidosis admitted for treatment developed features characteristic of rhinocerebral mucormycosis, confirmed by histopathologic examination, is presented. The patient had been experiencing symptoms of diabetes for one month before presentation to the hospital in state of diabetic ketoacidosis. Within a few days of admission he developed mucormycosis of the nasal cavity and the orbit which extended to the brain very fast and resulted in death. High index of suspicion form the clinical presentation in an immunocompromised patient, especially, one with diabetic ketoacidosis, is suggested to effect early intervention.

Brain Diseases↗

PubMed2000

An ovarian Sertoli-Leydig cell tumour in a 40 year old Ethiopian woman: case report.

Sertoli-Leydig cell tumors of the ovary are uncommon ovarian tumors. They belong to the ovarian stromal neoplasm. The most striking mode of presentation of these tumours is virilization due to androgen secretion. But approximately 50% of patients with Sertoli-Leydig cell tumors have no endocrine manifestations and usually complain of abdominal pain or swelling. Occasional tumors have been associated with various estrogen syndromes. A forty year old Ethiopian lady with well differentiated Sertoli-Leydig cell tumor of the left ovary presenting with features of virilization is described with clinicopathological correlation and literature review.

Abdominal Pain↗

PubMed2000

Struma ovarii in a 50 year old Ethiopian woman.

Struma ovarii represents the dominant growth of thyroid tissue in a teratoma. This exceedingly rare neoplasm is described in a 50 year-old Ethiopian woman who presented with right lower quadrant pain and mass of 10 years duration. The patient had nonspecific symptoms in addition to the above complaints. The diagnosis was disclosed by pathologic examination. This exceedingly rare neoplasm is discussed with clinicopathologic correlation and literature review.

Abdominal Pain↗

PubMed1999

Unusual presentation of rectal carcinoma in a young woman.

Advanced rectal carcinoma usually presents with rectal bleeding, tenesmus or alteration in bowel habits. Secondary deposits in the inguinal lymphnode is generally an indication of advanced disease. We report unusual presentation of advanced rectal carcinoma in a 23 year-old female patient who came presenting with symptoms of left inguinal lymphadenopathy and left leg swelling. There were no symptoms related to local effects of rectal carcinoma. First the patient was treated as a case of deep venous thrombosis. Fine needle aspiration biopsy provided the first clue to the nature of disease. To the best of our knowledge such unusual presentation of advanced rectal carcinoma has never been reported in Ethiopia. Rectal carcinoma should be considered in the list of secondary adenocarcinoma in the inguinal lymphnodes.

Adenocarcinoma↗

PubMed1998

Rhabdomyosarcoma (RMS) of the uterine cervix in two Ethiopian patients: case report.

Most rhabdomyosarcomas (RMS) of the female genital tract occur in infants and young children as sarcoma botryoides. To our knowledge, RMS of the cervix has never been reported in Ethiopia. Two patients with RMS of cervix in their second and third decades of life were seen in a short period of time span at Tikur Anbessa Hospital in the first half of 1996. Difficulties were encountered in reaching a diagnosis and appropriately managing the patients which necessitated the revision of previous biopsy result especially in the first patient. Both presented clinically with bloody vaginal discharge and cervical mass. RMS of the cervix deserves attention in a young patient with cervical mass and bloody vaginal discharge. The excised tissue should be subjected to histopathologic study. Treatment with polychemotherapy and/or radiation in addition to aggressive surgical approach should be made available to obtain good results.

Adolescent↗

PubMed1998

Teratoma of the neck in a newborn: case report.

Teratomas in the neck are rare neoplasms. Existing or potential airway obstruction is usually the main concern in acute management of these patients. A first case of cervical teratoma is described in an Ethiopian premature neonate born to an 18 year-old primigravida. The clinico-pathological features, including autopsy findings, are reviewed. Perinatal asphyxia secondary to huge neck teratoma is considered as the likely cause of death.

Adolescent↗