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Biomedical subjects

W Erler

Publications and source records attributed to W Erler.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Results of experimental immunization of calves with different Pasteurella antigens].

Calves immunised with different Pasteurella antigens (inactivated whole cells, sodium chloride extract) where challenged two weeks after the second immunization with the homologous strain. The intracutaneous application of whole cells of P. haemolytica A1 and P. multocida A was effective. The incidence of pneumonia was reduced and the pneumonic lesions were less severe. The sodium chloride extract was not effective.

Animals↗
PubMed1990

[Lysozyme in calves].

Relatively high lysozyme concentrations, depending on age, were recorded from intestinal content, spleen, liver, kidney, lung, lymph nodes, and mucosa of calves. Yet, only minor quantities of lysozyme were found in blood serum or plasma and in granulocytes. Physicochemical characterisation, precipitation, using polyclonal antisera, and crosswise neutralisation of lysis reaction were likely to suggest occurrence of immunological relationship reactions as well as differences between organ lysozymes, on the one hand, and intestinal lysozymes, on the other.

Age Factors↗
PubMed1990

[Bactericides against Pasteurella multocida in whole blood, plasma and lung lavage fluid of untreated and immunized young swine and calves].

The investigation of bactericidal effects in the whole blood and plasma of young pigs and calves against Pasteurella multocida has shown that such effects only come into being or are activated during the direct interaction between the host and pasteurellae, with effects being increased in previously immunized animals. The same is true for the antibodies which are detectable by indirect haemagglutination. There is no bactericidal effect in the concentrated lung lavage fluid against pasteurellae.

Animals↗
PubMed1987

Swine dysentery control in the German Democratic Republic and the suitability of injections of tiamulin for the programme.

In 1977 swine dysentery was made a notifiable disease in the German Democratic Republic, with the intention of eradicating it by the systematic treatment of clinically affected herds using intensive medication and hygiene control programmes. On individual farms the scheme appeared to be successful, but the national incidence of the disease did not decline, owing to the continuous presence of latently infected herds and the movement of carrier pigs to uninfected farms. In 1981 the scheme was re-appraised and a new scheme was introduced in one region where all the breeding herds were screened for the presence of Treponema hyodysenteriae; all positive herds were treated with either metronidazole or tylosin, and the movement of pigs into the region was controlled. This programme effectively eradicated the disease from the region and is being introduced to the rest of the country. Owing to concern about the safety of metronidazole and the development of resistance to tylosin, alternative antimicrobials were examined and tiamulin was selected to assess its suitability for inclusion in the programme. A 560 sow breeding herd and progeny were treated for five days with tiamulin at 10 mg/kg bodyweight. This was coupled with extensive cleaning, disinfection and rodent control programmes. The results of the trial showed that the clinical disease stopped in two days and that no further clinical signs were seen in the subsequent two-and-a-half years. Bacterial monitoring of faeces samples and colonic scrapings from dead pigs failed to identify viable T hyodysenteriae. There was a significant increase of 0.6 piglets weaned per litter and improvements in weaning weights and growth rates. It was concluded that tiamulin was suitable for inclusion in the swine dysentery eradication programme in the GDR.

Animals↗
PubMed1986

[The heptose region of lipopolysaccharides of Pasteurella multocida].

The heptose region of the lipopolysaccharides (LPS) of Pasteurella multocida consists of the trisaccharide L Hep 1----2 L Hep 1----3 L Hep or L Hep 1----3 L Hep 1----2 L Hep. This trisaccharide and the oligosaccharide consisting of 3 moles heptose and 1 mole glucose were isolated from the LPS of the strain D 33. The data suggest that the LPS biosynthesis of P. multocida is different from that of Salmonella spp.

Chemical Phenomena↗
PubMed1986

Lipid-A-antibodies--indicators for the risk of renal scarring in children with urinary tract infection.

The levels of IgG- and IgM-antibodies against lipid A were determined by an ultramicro-ELISA in 54 children between 2 months and 13 years of age with non-obstructive urinary tract infections at the onset of the infection and subsequently after 3, 6 and 12 months. Children older than 2 years who later developed renal scarring as shown by intravenous pyelograms had higher levels of IgG antibodies than those without scars. This correlation was not found in children younger than 2 years of age. IgM-antibody levels did not correlate with the risk of scar formation. We conclude that the IgG-antibody level against lipid A is a useful indicator for early recognition of children over the age of two years who will later develop renal scars. The ultramicro-ELISA technique makes screening for children at risk possible at a low cost.

Adolescent↗
PubMed1986

Electron microscopic visualization of the capsule of Pasteurella multocida.

The results of electron microscopic visualization of capsules of Pasteurella multocida by means of negative staining and section methods are described. Using ruthenium red or a complex of platinum in negative staining, relatively homogeneous capsules were visualized, using alcian-blue, coarse-fibrous structured capsules appeared. The incubation with antiserum partially revealed narrow capsule zones in the sections. Ferritin-linked IgG labelled amorphous material between the bacteria or floccular appendages on the bacterial surface. Gold-linked Con A deposited on thick cord structures, on loose material between the bacteria and sometimes on their cell wall.

Cell Wall↗
PubMed1981

[Characterization of structural elements in lipopolysaccharides of Pasteurella multocida].

In the main fraction of oligosaccharides obtained after the acetic acid hydrolysis of the lipopolysaccharides of the strain PM were identified: terminal bound glucose and L-glycero-D-manno-heptose, 1,2-,1,3,4-, and 1,3,4,6,-linked heptose. The oligosaccharide of the strain 1297 S contains terminal linked galactose, 1,4- or 1,6-linked glucose and 1,4-linked N-acetylglucosamine additionally. The molar ratios of these elements show the heterogenicity of the preparations. The determined molecular weights underline the R-character of the LPS. In the by-fractions of the acetic acid hydrolysis the known mannan and another polysaccharide with galactose and glucosamine were identified.

Cell Wall↗
PubMed1981

[Further characterization of lipopolysaccharides from Pasteurella multocida].

The biological properties, sedimentation behaviour, and electron-optically visualised structures of lipopolysaccharides from Pasteurella multocida were found to be identical with lipopolysaccharides from Enterobacteriaceae. Hard evidence to the effect that lipopolysaccharides from Pasteurella multocida are R-lipopolysaccharides were produced by the composition of monosaccharides together with experiments on the basis of disc electrophoresis.

Animals↗