Palmar fasciitis and arthritis with malignant neoplasms: a paraneoplastic syndrome.
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Biomedical subjects
Publications and source records attributed to W F Brereton.
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This gestational neoplasm arises from the trophoblast, the ectodermal layer of a fertilized ovum. Although benign, hydatidiform moles have the potential to progress to malignant trophoblastic disease. Molar pregnancy must be recognized promptly. The clinical presentation is usually vaginal bleeding, which may contain characteristic tissues. Diagnosis is confirmed by identification of hydropic avascular villi obtained by evacuation of uterine contents. The beta subunit of human chorionic gonadotropin is a valuable tumor marker.
Quinidine is cited as one of the most frequent causes of drug-induced thrombocytopenia. This case report describes the use of high-dose intravenous gamma globulin to rapidly reverse quinidine-induced thrombocytopenia in a patient at increased risk for bleeding because of the presence of an antitachycardia pacemaker and an automatic implantable cardiac defibrillator. This report suggests that this treatment may aid in a more rapid reversal of quinidine-induced thrombocytopenia in patients at high risk of bleeding.