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Biomedical subjects

W F Green

Publications and source records attributed to W F Green.

At least 37 records · Page 2Linked to original sources
PubMed1990

Characterization of airborne mineral dusts associated with farming activities in rural Alberta, Canada.

The dry and windy climate of the Western Canadian prairie provinces, combined with large scale agricultural activities, results in aerosolization or organic and mineral dusts. The purpose of this study was to conduct an environmental and minerological analysis of these dusts in order to estimate the risk for pneumoconiosis in exposed farmer populations. Two districts in central/southern Alberta were chosen for study. One of these regions was representative of a predominantly grain growing district with minimal use of irrigation; the other region was largely devoted to forage and irrigated crop production. Air pollution statistics showed a bi-modal distribution of total suspended particulates (TSP) with peaks corresponding with maximal farm activities in the spring and early fall. Analysis of bulk dust samples obtained from tractor cab filters showed that the majority of particles from both districts were within the respirable range (less than 5 microns). Samples from the forage-crop region contained more organic material, a greater water soluble fraction and had particles that were, on average, smaller and rounder than particles from the grain district. These differences were thought to reflect differences in irrigation patterns and use of fertilizers between the two districts. Free silica (quartz) content was also very variable and ranged from 1 to 17% on a mass basis. Respirable fibrous minerals were occasionally identified, however, no asbestos fibres, fibrous tremolite, or fibrous zeolites were identified. The results indicate that there is potential risk for mineral dust pneumoconiosis in heavily exposed farmer populations and that this risk will be influenced by local and regional factors.

Agriculture↗
PubMed1989

Reduction of house dust mites and mite allergens: effects of spraying carpets and blankets with Allersearch DMS, an acaricide combined with an allergen reducing agent.

Two studies were made to determine the acaricidal and allergen reducing properties of Allersearch DMS solution. In Study 1, samples of dust and carpet containing living mites were treated, in vitro, with DMS solution. No living mites were found in dust after 3-4 min or in carpets 50 min after treatment. In Study 2, mite counts and allergen estimation made on bed blankets before and after spraying with DMS solution showed a marked reduction in mite numbers (95%) and allergenicity (100-fold). Mite numbers and allergenicity stayed at this low level for 6 weeks. At 16 weeks both mites and allergens showed a slight increase, but were still significantly (P less than 0.001) below pretreatment levels.

Allergens↗
PubMed1986

House dust mites and skin tests in different Australian localities.

Dermatophagoides mite concentrations in household dust have been measured in three Australian towns with contrasting geographical features, climate, and degree of urbanisation. Mite allergen skin tests on school children living in these areas showed that the prevalence of positive reactions varied with mite concentrations. In Belmont, D. farinae as well as D. pteronyssinus were present in some of the dust samples. Skin test weals were larger in Busselton than in either Wagga Wagga or Belmont. The importance and practical implications of these findings are discussed.

Adolescent↗
PubMed1985

Renal transplantation. A 20-year experience in a Veterans Administration Medical Center.

Between March 1963 and December 1983, 324 renal transplants were performed in 273 veteran patients at the Veterans Administration Medical Center, Nashville, Tenn. Cadaver donors were used in 273 transplants, with an overall one-year patient survival of 72.5% and one-year functional graft survival of 50%. Twenty-four living-related transplants were performed, with an overall one-year patient survival of 89% and one-year functional graft survival of 75%. For analytical purposes the 20-year transplant experience was divided into five eras. One-year patient survival increased from 45% in era 1 to 84% in era 5, while functional graft survival increased from 45% to 70%. Death has occurred in 139 patients, with sepsis being responsible for the largest number of early deaths. Cardiovascular disease was responsible for most late deaths.

Adult↗
PubMed1983

Factors influencing the outcome of kidney transplants.

This study is a multifactorial analysis of 389 transplants performed from June 1977 to December 1981. Analysis of the effects of transfusions antilymphocyte serum (ALS), histocompatibility testing, gender, and patient risk factors (presence of concomitant disease, greater than 50 years of age, etc.) was done. Two-hundred fifty-three patients received cadaver kidneys and 136 patients obtained kidneys from a relative. Two-hundred eighty-three (73%) patients received blood transfusions prior to transplantation. Our data showed that recipients receiving transfusions prior to transplantation had a significantly higher graft survival than those who were not transfused in both cadaveric and related graft recipients. Two-hundred twenty-one (56%) patients received ALS following the transplant. This group had a 15% higher graft survival than a comparable group. Analysis of histocompatibility testing data shows approximately 5% higher functional graft survival between each match grade. Surprisingly, female patients receiving kidneys from living related donors had a 16% higher graft survival than male patients. In cadaver recipients female patients had a 10% higher patient survival as compared to male patients. The risk factor status of recipients affected not only graft survival but patient survival, which probably is due to the consequences of immunotherapy. The authors' conclusion is that the above mentioned factors may be additive in nature. Further, multivariable analysis is necessary in order to correctly transplant data.

Antilymphocyte Serum↗
PubMed1981

Modulation of Schistosoma mansoni egg-induced granuloma formation: I-J restriction of T cell-mediated suppression in a chronic parasitic infection.

Newly formed hepatic granulomas around Schistosoma mansoni eggs become progressively smaller during the chronic (greater than or equal to 15 weeks after infection) phase of the disease. This reduction in granuloma size, termed "modulation," is known to be caused in part by a T lymphocyte that can adoptively transfer modulation to 6-week-infected mice. The present study examines a possible role for the I-J locus in regulating the suppressor T lymphocyte aspects of modulation. Adoptive transfer between congeneic B10.A(3R) and B10.A(5R) mice (differing at the I-J locus) indicated that optimal suppression is dependent upon homology at the I-J locus. In vivo treatment of chronically infected mice with microliter amounts of antiserum specific for the recipient's I-J determinant blocked modulation during chronic infection and prevented adoptive transfer of suppression to 6-week-infected mice. The in vivo regimen of anti-I-J had no effect on anti-schistosomal egg antigen titers during chronic infection. These results demonstrate an I-J restriction for suppression. It appears that the suppressor T lymphocyte circuit responsible for this aspect of modulation requires an I-J positive lymphocyte.

Animals↗