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Biomedical subjects

W F Kennedy

Publications and source records attributed to W F Kennedy.

At least 19 recordsLinked to original sources
PubMed1994

A return-based alternative to IRR (internal rates of return) evaluations.

A dilemma often faced by healthcare financial managers is whether to describe a potential investment project to organizational decision-makers in terms of the projects' internal rates of return (IRR) or to use the net present value (NPV) method. The IRR represents an intuitively appealing method of measuring investment value, but a number of conceptual and methodological problems associated with IRR measurement would seem to argue the use of the NPV method. Unfortunately, while the NPV measure is theoretically valid, it lacks the intuitive appeal of the IRR in communicating the value of investment alternatives. This article details an alternative method of measuring return that incorporates all the intuitive appeal of the conventional IRR, but few of the shortcoming associated with that measure.

Capital Expenditures↗
PubMed1993

Use of pulsed electromagnetic fields in treatment of loosened cemented hip prostheses. A double-blind trial.

A double-blind trial of pulsed electromagnetic fields (PEMFs) for loosened cemented hip prostheses was conducted at two centers. Of the 40 patients who enrolled, 37 met entry criteria and were available for analysis. All patients completed six months of treatment (either active or control units). Success was determined clinically by a Harris hip score greater than or equal to 80 points (or an increase of ten points if initially greater than or equal to 70 points). Ten of the 19 active units were successes (53%), whereas two of the 18 controls (11%) exhibited a placebo effect, a statistically significant and clinically relevant result. A 60% relapse rate among the active successes was seen at 14 months poststimulation, and despite maintenance therapy of one hour per day, the relapse rate increased to 90% at three years. These data suggest that for loosened cemented hip prostheses, use of PEMFs is a treatment option only to delay revision hip surgery.

Adult↗
PubMed1991

Sciatic nerve monitoring during revision total hip arthroplasty.

This study presents a simple method of intraoperative sciatic nerve monitoring during revision total hip arthroplasty (THA), utilizing intraoperative, somatosensory evoked potentials. Using this method, the sciatic nerve was protected when surgical correction of shortened limb length was necessary during revision THA. Twenty-three revision THAs were performed using intraoperative sciatic nerve monitoring. No postoperative peripheral nerve complications occurred, with an average increase of 18 mm in leg length, ranging from 6 mm to 43 mm.

Adult↗
PubMed1991

Radiation therapy to prevent heterotopic ossification after cementless total hip arthroplasty.

Clinical and roentgenographic observations on a postoperative low-dose radiation of 1000 cGy for prevention of heterotopic ossification in high-risk patients after 48 noncemented total hip arthroplasties demonstrated no overall statistical difference in the Harris hip scores between the treated group (92.2) and the control group (91.0). There was no difference in the incidence of radiolucent lines about the components, and there were no revisions for aseptic loosening in the treated group. The incidence of clinically significant (Brooker Grades III and IV) heterotopic bone formation was lower in the treated group (7%) than in the control group (32%). This difference in the incidence of heterotopic bone formation was statistically significant. Radiation therapy was effective in preventing postoperative heterotopic bone formation in biologically fixed total hip implants.

Adult↗
PubMed1977

Cardiovascular effects of total hip placement in man. With observations on the effects of methylmethacrylate on the isolated rabbit heart.

The cardiovascular effects of total hip placement were evaluated in 10 surgical patients, aged 55 to 82, while receiving fluroxene-N2O-O2 anesthesia. The anesthetic regimen caused mild cardiovascular depression. The placement of the acrylic cement into the acetabulum and femoral shaft also induced mild cardiovascular depression, but these changes were not significant at p less than 0.05. In one 67-yr-old woman, there were significant reductions of cardiac output and stroke volume 2 min after the insertion of acrylic into the femoral shaft, despite careful replacement of intravascular loss and careful anesthetic management. Methylmethacrylate (1 X 10(-6) to 1 X 10(-4), v/v) was administered to 24 isolated perfused rabbits hearts. These concentrations of methylmetacrylate are of the same order as measurable blood levels in surgical patients. There was a dose-dependent depression of left ventricular dP/dt correlated with a depression of the spontaneous heart rate. When the bradycardia was prevented by electrically pacing the hearts or the administration of atropine, the depressed dP/dt rose to control levels. Reduction in myocardial temperature and heart rate by means of reduction in perfusate temperature of the isolated hearts reduced the myocardial depressant effect of methylmethacrylate.

Aged↗