A metabolic myopathy due to absence of muscle phosphorylase.
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Biomedical subjects
Publications and source records attributed to W F MOMMAERTS.
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The activation of the glycolysis of resting muscle by increased extracellular potassium is dependent upon the simultaneous presence of calcium, but not of sodium ions. This regulation of metabolism by a membrane characteristic seems to act upon an early link in the glycolytic enzyme chain.
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The length-tension diagram, the force-velocity relation, the characteristics of the series elasticity, and the duration of the active state have been studied on the papillary muscle preparation of the cat heart, and on other examples of cardiac muscle. Positive inotropic changes such as the staircase phenomenon and post-extrasystolic potentiation occur without lengthening, but frequently with shortening, of the duration of the active state. They are accompanied by an increased velocity of contraction, and may be caused either by an intensification of the active state or by an alteration of the force-velocity characteristics of the contractile component. The changes in the force-velocity relation point to an adaptation of the velocity-efficiency relation in dependence on the frequency of contraction.
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A recording dual beam light-scattering photometer is described which permits kinetic studies involving changes in turbidity, and which is not, as are single photocell instruments, affected by the errors due to the attenuation of the scattered light within the turbid medium. With this method, a renewed study has been made of the physical changes occuring in actomyosin under the influence of ATP.
Pyruvate kinase and phosphoenolpyruvate, added to actomyosin, cause a maintenance of the response of the actomyosin to stoichiometric amounts of ATP. This steady state maintenance depends on the presence of Mg ions.
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