PubMed Health⌕ Search

Biomedical subjects

W F Ng

Publications and source records attributed to W F Ng.

63 records · Page 4Linked to original sources
PubMed1990

Occult fatal pulmonary embolism with disseminated intravascular coagulation. An unusual case masquerading as miliary tuberculosis.

We report a fatal case of occult pulmonary embolism complicating bronchogenic carcinoma which presented with rapidly progressive pulmonary miliary shadows and respiratory failure. A clotting profile abnormality compatible with disseminated intravascular coagulation was noted. Postmortem examination showed extensive clots occluding the major pulmonary vessels and areas of pulmonary infarcts. Histologic examination revealed fibrin deposition in the microvasculature compatible with DIC. Cases of pulmonary embolism with DIC have previously been reported, but this is the first case with pathologic confirmation. Thus, unusual presentation with diffuse lung shadow and DIC should not deter the clinician from correct diagnosis so that appropriate treatment can be promptly started.

Adult↗
PubMed1989

Identification of members of the P-glycoprotein multigene family.

Overproduction of P-glycoprotein is intimately associated with multidrug resistance. This protein appears to be encoded by a multigene family. Thus, differential expression of different members of this family may contribute to the complexity of the multidrug resistance phenotype. Three lambda genomic clones isolated from a hamster genomic library represent different members of the hamster P-glycoprotein gene family. Using a highly conserved exon probe, we found that the hamster P-glycoprotein gene family consists of three genes. We also found that the P-glycoprotein gene family consists of three genes in mice but has only two genes in humans and rhesus monkeys. The hamster P-glycoprotein genes have similar exon-intron organizations within the 3' region encoding the cytoplasmic domains. We propose that the hamster P-glycoprotein gene family arose from gene duplication. The hamster pgp1 and pgp2 genes appear to be more closely related to each other than either gene is to the pgp3 gene. We speculate that the hamster pgp1 and pgp2 genes arose from a recent gene duplication event and that primates did not undergo this duplication and therefore contain only two P-glycoprotein genes.

ATP Binding Cassette Transporter, Subfamily B, Mem↗
PubMed1987

Reactive hemophagocytic syndrome: a study of 7 fatal cases.

Reactive hemophagocytic syndrome is a clinico-pathologic entity characterized by systemic proliferation of non-neoplastic histiocytes showing phagocytosis of hemopoietic cells, resulting in blood cytopenia. It is best known to be associated with virus infection, but other associated diseases have also been implicated. The clinical and pathological findings of 7 fatal cases are described. The syndrome affected both sexes of a wide age range, and all patients had fever. Significant laboratory findings were blood cytopenia, abrupt drop in the blood cell counts, deranged liver function tests and abnormal coagulation profile. The associated diseases were diverse: two patients had bacterial infection; two had peripheral T-cell lymphoma; one had disseminated undifferentiated carcinoma of the ovary; one had both tuberculosis and disseminated nasopharyngeal carcinoma, and one had no obvious underlying disease. It is postulated that lymphokines secreted by lymphoid cells or tumor cells may be responsible for the systemic activation of histiocytes. The differential diagnosis from malignant histiocytosis is discussed.

Adolescent↗
PubMed1987

Sclerosing adenosis cancerized by intraductal carcinoma.

Sclerosing adenosis is a common proliferative lesion of the mammary lobule which is not associated with an increased risk of developing breast cancer. An unusual case of florid sclerosing adenosis showing extensive cancerization by intraductal carcinoma is reported. The neoplastic nature of the sclerosing lesion can be recognized by the unusual distension of the tubules by cells and the subtle cytological changes, and further confirmed by finding foci of classical intraductal carcinoma.

Adult↗
PubMedDate not supplied

Kikuchi's histiocytic necrotizing lymphadenitis. Diagnosis by fine needle aspiration.

Two cases of Kikuchi's histiocytic necrotizing lymphadenitis diagnosed by fine needle aspiration (FNA) of enlarged lymph nodes are reported. The FNA smears contained randomly activated lymphoid cells, necrotic debris, karyorrhectic cells and prominent histiocytes, suggesting the presence of reactive lymph nodes. The true nature of the lesions was evident from the examination of cell block sections prepared from tissue fragments in the aspirates, which preserved the architectural relationships of the different cell types. The same patterns were found in retrospectively and subsequently examined excised lymph nodes from these cases. The differential diagnosis of this entity, which may simulate a malignant lymphoma because of the presence of large numbers of activated lymphoid cells, is discussed and the value of preparing FNA cell blocks is emphasized. Though this rare benign disease may be suspected clinically in the more typical cases, such as young women with cervical lymphadenopathy, fever, neutropenia and otherwise excellent condition, the diagnosis cannot be made without a lymph node biopsy, which FNA may be able to provide in some instances.

Adult↗
PubMedDate not supplied

Rehydration of air-dried smears with normal saline. Application in fluid cytology.

Ninety fluid specimens (30 each of urine, ascitic and pleural fluid) were studied by preparing three comparable smears. One was air dried for Giemsa stain, one wet fixed in 95% ethanol and one dried on a hot plate at 37 degrees C, rehydrated in normal saline for 30 seconds and fixed in ethanol. The latter two were stained with Papanicolaou stain, and a comparison was made of the (1) retention of red blood cells, (2) retention of epithelial or mesothelial cells, and (3) cytologic preservation. The Giemsa-stained smear was used as a control for (1) and (2). Complete lysis of red blood cells was noted in the rehydration smears as compared with 70% red blood cell retention in the wet-fixed smears (P < .01). The rehydration smears retained 78% urothelial cells as compared with 55% in the wet-fixed smears (P < .01). For ascitic and pleural fluid the cell retention did not differ significantly. The wet-fixed smears scored better for overall cytologic preservation, but the difference was not significant. The rehydration smears showed a decrease in the chromaticity of staining, more flattened cell clusters and slight cell enlargement. The rehydration method was beneficial for urine and blood-stained body cavity fluids.

Ascitic Fluid↗