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Biomedical subjects

W F Yee

Publications and source records attributed to W F Yee.

7 recordsLinked to original sources
PubMed1990

Congenital tracheoesophageal fistula (H-type) in a six-year-old.

The case of a six-year-old boy with newly diagnosed tracheoesophageal fistula of the H-type is presented. This diagnosis is usually made in the neonatal period, but since the symptoms may mimic other respiratory illnesses and radiologic diagnosis may be difficult, the condition may go undiagnosed for years. Since correction of a tracheoesophageal fistula is curative, the diagnosis should be entertained in any child with recurrent respiratory symptoms, especially when associated with meals. A brief discussion emphasizes the importance of good communication between the clinician and radiologist and of careful radiologic evaluation.

Child↗
PubMed1986

CO2 responsivity in the mouse measured by rebreathing.

We have modified the rebreathing method to study CO2 responsivity in very small mammals. Tidal volume (VT) and frequency (f) of pentobarbital-anesthetized mice were measured during rebreathing from a closed circuit, primed with 95% O2, 5% CO2, through which the gas was constantly circulated at 0.5 l X min-1. The circuit consisted of T-tube from a plethysmograph, Tygon tubing with compliant element, CO2 analyzer and pump, in series. Circuit PCO2 (PctCO2), which was recorded continuously during spontaneous breathing, rapidly equilibrated with end-tidal PCO2. CO2 response curves were constructed from extrapolated minute ventilation (V), VT, f and parameters of breath-to-breath timing, respectively, on PctCO2. Analyses of slopes of the response curves, change from onset of rebreathing to peak response, and PctCO2 at which the response peaked revealed that CO2 stimulates V by increasing f and VT and that this is effected by facilitation of central inspiratory-expiratory phase switching and inspiratory drive mechanisms. However, the stimulatory effect of CO2 on phase switching was not sustained, with maximal effect occurring before peak V. The advantages and facility of the modified rebreathing method make it suitable for studies of other small mammals, including neonates.

Animals↗
PubMedDate not supplied

Diagnostic problems in hypersensitivity lung disease.

Hypersensitivity Lung Disease (HLD) includes Hypersensitivity Pneumonitis (HP), IgE triggered asthma and Allergic Bronchopulmonary Aspergillosis (ABPA). HP and ABPA are neither common nor rare. Both are important to diagnose as they can result in progressive irreversible lung damage. Serologic tests are useful in diagnosing or excluding HP and ABPA although the diagnostic skill of the physician is of prime importance. We report eight cases which were diagnostic problems in which the initial serologic examinations were incorrect. The diagnostician must be aware of both the clinical possibility of the HLD but also of the possibility or probability that the serologic report is not correct.

Adult↗