Biomedical subjects
Publications and source records attributed to W Féaux de Lacroix.
The rare case of an isolated ovarian metastasis of a primary adenocarcinoma of the gallbladder is reported: the ovarian metastasis was associated with androgen and estrogen production. The differential diagnoses are discussed.
Morphological findings recorded from chondromatous tumors of unknown biological behaviour (n = 40) were compared with those obtained from unequivocal chondrosarcomas (n = 27), and the histological results were evaluated by clinical outcome. The morphological details were analysed by histological set up and summarized by Mirra et al. (1985): Two benign patterns, the enchondroma encasement pattern and the island of cartilage patterns, were the most common findings in cartilaginous tumors of unknown biological behaviour. Malignant patterns, such as chondrosarcoma permeation, invasion of the Haversian system, soft tissue mass and bands of fibrosis patterns were detected only in unequivocal chondrosarcomas. However, the enchondroma encasement pattern could be focally demonstrated also in central chondrosarcomas (n = 3), a phenomenon, which in our opinion could not be interpreted as being indicative of a preexisting benign lesion. Morphological classification of chondromatous tumors of unknown biological behaviour, as a group of benign cartilaginous tumors, enables their discrimination from unequivocal chondrosarcomas. This was also confirmed by the significant difference (p = 0.0065; Mantel-Cox) among survival curves after Kaplan and Meier (1958). We conclude that the above criteria, when applied with due caution, are helpful in classifying chondromatous tumors.
The case of a woman of 48 years of age suffering from pulmonary lymphangiomyomatosis is presented. Chest radiographs showed the reticular infiltrate of diffuse interstitial lung disease, whereas high resolution CT illustrated multiple, well-defined cystic lesions distributed diffusely through the lungs without fibrotic changes or nodular densities. The patient underwent open lung biopsy and pleurodesis because of recurrent pneumothorax. Treatment with medroxyprogesterone was initiated.
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Based on 46 enosteal cartilaginous tumours of the long tubular bones (43 patients) the established radiological and Mirra's histopathological criteria of tumour status are assessed independently and compared retrospectively. In lesions of Lodwick's type I B (37 cases) with mineralisation of the cartilaginous matrix and facultatively cortical arrosion, lack of periosteal reaction, destruction of the corticalis and parosseal tumour extension none of Mirra's histopathological criteria of malignancy was found. It may be expected that biopsy and histopathological examination will not give valuable additional information in this radiological constellation, because there are no known definite histopathological criteria of benignity. Suspicious radiological findings should prompt complete resection of the lesion. Biopsy and histopathological classification are always crucial when matrix mineralisation is lacking and therefore the diagnosis of a cartilaginous tumour cannot be established radiologically.
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The experience with magnetic resonance imaging (MRI) of 81 patients with primary bone tumours and tumour-like lesions is reported. MRI proved to be a sensitive method of detecting primary bone tumours. Intramedullary and extraosseous parts of bone tumours were delineated better than by plain films and computed tomography (CT). Surgical clips and Harrington rods did not appreciably limit the estimation of tumour recurrence. MRI provided definite advantages compared to CT in the surgical staging of bone tumours and tumour-like lesions. MRI was found to be an imaging method with low specificity. Differentiation of tissue components, such as haematoma, fat, necrosis, and cystic areas, led to a specific diagnosis only in rare cases. Plain films and CT were found to be superior to MRI in assessing the biological activity and the differential diagnosis of bone tumours and tumour-like lesions.
The results of MRT in 41 patients with bone diseases are reported. MRT proved to be a sensitive method in evaluating localised bone lesions. MR provided definite advantages in comparison with computed tomography and plain films in the determination of the intramedullary and extraosseous extent of circumscribed bone lesions. A better characterisation of the nature and histology of bone changes was not possible with MRT. Diffuse bone marrow disease are well demonstrable via MRT.
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It is generally accepted that cancer has strong effects on bone marrow cells (e.g. tumor-associated anaemia). The present investigation studies the proliferation kinetics of haemopoietic cells and the topographic differences in proliferation patterns in the bone marrow of tumor-bearing animals and controls. It was demonstrated that the differences in the cell cycle times, whether between peripheral and central parts of the bone marrow or between the experimental group and the control group, were slight or nonexistent. However, the growth fraction showed an increased proliferation rate in tumor-bearing as compared with normal animals (57% and 37%, respectively).
The aim of the present investigation was to study the effect of a high bolus injection (1 X 2.1 mg) of vincristine (VCR) during the phase of tumour growth retardation at the 14th day after transplantation and to compare the findings with the results of single (1 X 0.35 mg) and repeated (6 X 0.35 mg) applications of this cytostatic drug. Furthermore, an attempt was made to induce a synchronization of tumour cell proliferation. It was found that the effect on the volume growth was very pronounced after the high bolus injection and the repeated application of vincristine compared with the single low dose of the cytostatic drug. A synchronization of the tumour cell proliferation by flow out of the mitotic block could not be demonstrated. On the other hand a modest simultaneous recruitment of previously non-cycling tumour cells into the cell cycle occurred in the periphery of the tumour after the high bolus injection. The repeated application and the high bolus injection of VCR increased the cytostatic effect, especially in the tumour centre, related to the more slowly proliferating tumour cell compartment.
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The aim of the present investigation was to compare the effects of repeated and single applications of vincristine (VCR) to a solid tumor in mice during the phase of tumor growth retardation 14 days after transplantation. Furthermore an attempt was made to induce synchronized tumor cell proliferation. Retardation of volume growth was found to be very much more pronounced after repeated application of VCR than after a single dose of this cytostatic drug. The intensity of the effect decreased within the tumor itself from the periphery to the centre. A synchronization of tumor cell proliferation by flow out from the mitotic block or by a high simultaneous recruitment of previously noncycling tumor cells into the cell cycle could not be demonstrated.
In the course of adjuvant single-agent chemotherapy with dacarbazine after extirpation of malignant melanoma, a fatal complication was observed in four of our patients. During the second cycle of therapy liver failure due to massive hepatic necrosis supervened, with widespread thrombosis of liver veins. The clinical and pathologic features of our patients are compared with the findings in eight published cases. The possible pathogenesis is discussed in detail, and Budd-Chiari syndrome caused by an allergic thrombophlebitis with secondary liver cell necrosis seems to be most probable.
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The aim of the present investigation was to study changes in cell proliferation kinetics with time after transplantation in a solid transplantable mammary carcinoma of the C3H mouse. From growth curves and tumour doubling times, three different experimental times were chosen; the exponential phase of growth on the 7th day post-transplantation, during the phase of retardation on the 21st day after transplantation and in the stationary phase of growth on the 30th day after transplantation. It was found that the cell loss factor contributed primarily to the retardation of volume growth. The lowering of the growth fraction played a minor part in the delay of growth while the duration of cell cycle was not prolonged before the plateau phase of growth on the 30th day after transplantation was reached.