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Biomedical subjects

W Feigl

Publications and source records attributed to W Feigl.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Prostacyclin formation in human cancer tissue of the gastrointestinal tract (author's transl)].

Prostacyclin synthesis was studied by means of bioassay in histologically classified biopsy material derived from the human gastrointestinal tract. Tumour tissue generated significantly more prostacyclin than normal tissue. Whether this enhanced PGI2 formation is due to an increased number of endothelial cells in tumour tissue, or represents a characteristic property of the tumour cell itself is not yet clear. This property could be used in future for the detection and control follow-up of malignant disease by means of radioimmunological determination of stabile metabolites as a tumour marker.

Adult↗
PubMed1981

[A malignant mixed tumor of the breast].

A case of a malignant mixed tumor of the female breast is presented. The epithelial part of it showed characteristics of a benign adenoma, the mesenchymal component those of a polymorphonuclear and spindle cellular sarcoma. Pathogenesis and histogenesis of this neoplasm as well as the literature on the subject are discussed. The incidence of this tumor and of sarcomas of the breast, in general is reported.

Adenoma↗
PubMed1980

Prostacyclin (PGI2)-generation by different types of human atherosclerotic lesions.

Unaltered human arterial tissue as well as different types of macroscopically and microscopically characterized atherosclerotic lesions were microdissected under a preparation microscope. The prostacyclin formation was examined using its potent platelet aggregation inhibition in vitro according to Moncada's bioassay. In contrast to different PGI2-formation in various experimental animal models the generation in the different lesion types in terms of wet weight was statistically significantly (p less than 0.001) diminished in comparison to normal control tissue. However, the PGI2- formation in different lesion types is comparable. Accepting the hypothesis delivered earlier by us, that the arterial wall is able to react upon exogenous noxes with a temporarily enhanced PGI2-formation, followed (after ceasing) by a decrease of PGI2-synthesis (exhaustion phenomenon) it can be concluded, that the critical stage is prior to the fatty streak formation, which is a preatherosclerotic lesion. Therefore, PGI2-generation-exhaustion might be mainly responsible for initiation and progression of atherosclerosis, probably before any detectable morphological alterations.

Aged↗
PubMed1980

Evidence that thrombus organizing blood derived cells produce prostaglandin I2-.

An artificial vessel replacement, which is athrombogenic and impermeable for a migration from the adjacent tissue, was implanted end to end into the thoracic aorta of 10 sheep. The center of this tube has a Dacron surface, which is known to trap blood elements. We examined the tissue samples built up by blood derived cells between 2 and 84 days morphologically by means of light microscopy as well as by SEM and TEM. We checked the thrombus fragments of 7 cases for their PGI2-generation using MONCADA's bioassay. In our specimens we found an average activity of 4, 7 pg PGI2 mg/min. The morphological examination revealed different stages of thrombosis and organization consisting of a large number of cells. Macrophages, fibroblast like cells, myofibroblasts as well as endothelial cells and foreign body giant cells around the Dacron fibers could be found. Our experimental design excludes the ingrowth of mesenchymal elements, which suggests that blood derived cells are able to produce PGI2.

Aging↗
PubMed1980

Atherosclerosis and mortality statistics.

WHO mortality statistics are subject to severe criticism all over the world due to the ICD code, the monocausal evaluation and th inhomogenity of data which are only partially verified by post mortem findings. Despite this fact WHO statistics are the only possibility to compare morality in different areas. In order to prove their reliability we have collected data of patients who have died in 9 Vienna hospitals. Our material consists of more than 15000 out of 25000 death cases in the year 1976. The autopsy rate was about 70%. To handle this amount of datas a computer system was used. In comparison with the official Austrian statistics our total atherosclerosis rate was higher due to the multicausal evaluation and the much higher percentage of CHD. Atherosclerosis of the brain was found in a lower percentage than officially mentioned when autopsy was performed. An example for single case studies is the myocardial infarction in a defined age group to support the importance of statistics based on a high rate of autopsies and the use of electronic data processing.

Aged↗
PubMed1979

[Carcinoma of the uterus in the Austrian mortality statistics. 1. Carcinoma of the uterus in Viennese autopsy reports 1976 (author's transl)].

The official mortality statistics in Austria fail to report the localization of uterine cancer in nearly two thirds of cases and, thus, the annual death rate of women with cervical versus endometrial cancer is not clear. These two diseases behave totally differently with regard to their aetiology, age distribution, early diagnosis, therapy and prognosis and, therefore, a separate analysis is necessary. This study presents an analysis of the incidence of uterine cancer in a series of 7,276 women who died in Vienna hospitals in 1976. Of the 151 cases (2% of all the women in the examined collective) 106 died of cervical carcinoma, 33 of endometrial carcinoma and 9 of unspecified uterine carcinoma. The average age of women who died of cervical carcinomas was 60 years, whilst that of patients with endometrial carcinoma was 71.7 years. In 12.6% of cases double carcinomata were found. The relation between deaths from cervical carcinoma to endometrial carcinoma is 3.3:1. If this ratio is applied to the 942 deaths from uterine carcinoma in 1976 in Austria, then one can estimate that more than 700 women must have died of cervical carcinoma and more than 200 of endometrial carcinoma. The 303 deaths from cervical carcinoma and 65 from endometrial carcinoma reported in the official mortality statistics are, therefore, totally misleading and ought not to be used as a basis for epidemiological investigations.

Austria↗
PubMed1979

[Mesothelioma of the peritoneum with pulmonary metastases (author's transl)].

Report of the case history of a female patient suffering from malignant mesothelioma of the peritoneum. Exceptional findings were a dense nodular hematogenic dissemination over both lungs and the duration of disease, which till now extends over 35 months. Pathogenesis, course of disease, diagnosis therapy and epicrisis are discussed.

Adult↗
PubMed1979

[Carcinoma of the uterus in the Austrian mortality statistics. I. Carcinoma of the uterus in Viennese autopsy reports 1976 (author's transl)].

The official mortality statistics in Austria fail to report the localization of uterine cancer in nearly two thirds of cases and, thus, the annual death rate of women with cervical versus endometrial cancer is not clear. These two diseases behave totally differently with regard to their aetiology, age distribution, early diagnosis, therapy and prognosis and, therefore, a separate analysis is necessary. This study presents an analysis of the incidence of uterine cancer in a series of 7,276 women who died in Vienna hospitals in 1976. Of the 151 cases (2% of all the women in the examined collective) 109 died of cervical carcinoma, 33 of endometrial carcinoma and 9 of unspecified uterine carcinoma. The average age of women who died of cervical carcinomas was 60 years, whilst that of patients with endometrial carcinoma was 71.7 years. In 12.6% of cases double carcinomata were found. The relation between deaths from cervical carcinoma to endometrial carcinoma is 3.3:1. If this ratio is applied to the 942 deaths from uterine carcinoma in 1976 in Austria, then one can estimate that more than 700 women must have died of cervical carcinoma and more than 200 of endometrial carcinoma. The 303 deaths from cervical carcinoma and 65 from endometrial carcinoma reported in the official mortality statistics are, therefore, totally misleading and ought not to be used as a basis for epidemiological investigations.

Austria↗