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Biomedical subjects

W Felber

Publications and source records attributed to W Felber.

10 recordsLinked to original sources
PubMed1989

[Results of the use of lithium to prevent recurrence of affective psychosis].

The efficacy of lithium treatment in preventing relapse in phasal psychoses was tested by the re-examination of 99 patients at a Dresden clinic whose treatment had on average exceeded ten years. Results and progress were compared with those of patients starting treatment since the introduction of the lithium treatment in the year 1979. Phase or subphase frequency and duration, conditions of treatment, suicide attempts, unfitness for work, and registration as a disabled person were among the aspects considered.

Bipolar Disorder↗
PubMed1988

[Lithium strumas and their psychiatric relevance].

Basing on 172 clinically recorded goitres among 787 patients treated with lithium (21.9%) we studied the question as to whether goitre formation due to lithium has any relevance within the concept of relapse prevention in affective disorders. A statistical comparison of essential disease parameters between the group of patients suffering from struma (goitre) and the total group shows that there is no special type or course of affective disorder with a particular affinity to the development of struma. Likewise, we can conclude from a comparison of treatment course and effectively parameters between both groups that development of struma under influence on the course of treatment or on the efficiency of prophylaxis. The results point to an irrelevance of lithium goitre in respect of psychiatric effects (this does not imply that it is irrelevant in respect of general medical aspects or endocrinology).

Adult↗
PubMed1987

[Lithium prevention of depression 100 years ago--an ingenious misconception].

The rediscovery of C. Lange's book "Uber periodische Depressionszustände und ihre Pathogenesis auf dem Boden der harnsauren Diathese", Copenhagen 1886, in a German translation by H. Kurella in 1896, gave rise to appreciate its value, to make its misconception intelligible, and to write down the author's and the translator's course of life. In his booklet Carl Lange gives a specification of depression in a most modern form. It is thrilling to read his report on about 2000 depressed out-patients successfully treated over a 20-year-period - from today's point of view lege artis - with lithium carbonate as a long-term-prophylaxis for recurrent depression. His intricate misconception is based upon his therapeutic orientation of treating gout and "uric acid diathesis", respectively. This conception of depression as "brain gout", part of an inflationary enlarged pathogenesis of numerous internal, neurological, and other diseases, had been set up by Garrod. "Brain gout" was a curiosity in the established psychiatry and disappeared from scientific thinking with a new medical knowledge of gout and rheumatism. With that, of course, the pioneering knowledge of the effectiveness of lithium disappeared too.

Denmark↗
PubMed1976

[Extrapyramidal syndromes as side-effects of metoclopramide (Cerucal) medication].

The authors, by describing their own observations made on eight patients showing extrapyramidal syndromes as side effects of metoclopramide (Cerucal) medication, report the various kinds of possible side effects, discussing their conformity with side effects produced by conventional neuroleptics and showing methods of treatment. Metoclopramide is known to produce three froms of extrapyramidal and motor side effects, namely: 1. Dyskinetic syndrome; 2. acathisia; and 3. Parkinson's syndrome. Therapy is in the following form regardless of the particular side effect produced by the said drug: 1. Administration of antiparkinsonian remedies; 2. administration of coffein; and 3. discontinuation or drastic reduction, respectively, of the daily dose of Cerucal.

Adult↗