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Biomedical subjects

W G Beamer

Publications and source records attributed to W G Beamer.

115 records · Page 7Linked to original sources
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Inherited ateliotic dwarfism in mice. Characteristics of the mutation, little, on chromosome 6.

A new autosomal recessive mutation in the mouse, little (lit), has been shown to be located on Chromosome 6. The mutation in the homozygous state causes ateliotic dwarfism that is first detected at 15 days of age by decreased body weight. Long bone lengths are significantly reduced. Skull width, however, is not affected. Female little mice are fully fertile; they may lose their first litters. Although most of the little males sire one or two litters, they rarely sire a third litter. Analysis of pituitary extracts electrophoresed on acrylamide gels reveal a significant reduction of the two anterior pituitary hormones, GH and PRL, in both male and female little mice. Because the little mouse shares a number of similarities with the human ateliotic dwarfism, isolated growth hormones deficiency type I, it may be a useful animal model for this inherited human growth disorder.

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New mouse dw allele: genetic location and effects on lifespan and growth hormone levels.

We have reported the finding of a new mutation at the dwarf locus, named dwarf-J, gene symbol dwJ, in the C3H/HeJ inbred mouse strain. The C3H/HeJ-dwJ/dwJ mice are like DW/J-dw/dw mice in that both homozygotes are virtually devoid of GH in either pituitary glands or serum. Lifespan of dwJ/dwJ mice was not reduced. Linkage experiments designed to assign the dw gene, together with another gene weaver (wv), were successful in that both were found to be on chromosome 16. The dw locus is probably more proximally located on chromosome 16 than the wv locus.

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Anorexia, a recessive mutation causing starvation in preweanling mice.

A new autosomal recessive lethal mutation in mice, anorexia (anx), located close to pallid (pa) on chromosome (chr) 2, is described. Mutant mice are characterized by growth failure, an emaciated appearance, and abnormal behavior including headweaving, body tremors, uncoordinated gait, and hyperactivity during the late preweanling period. Data suggest that the mutant mice are not ingesting the levels of nutrients necessary to sustain life. This mutation may provide an important tool for studying the neurobiology of suckling behavior in the preweanling animal.

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Ultrastructural aspects of the goiter in cog/cog mice.

Thyroids of congenitally goitrous (cog/cog) mice were studied with light and electron microscopy. The principal alteration in follicular cells was their largely overdistended rough endoplasmic reticulum (RER). Our findings resemble the ultrastructural features of human hypothyroid goiter caused by a thyroglobulin (TG) defect and thus support the previously suggested abnormalities of TG synthesis and/or processing in cog/cog mice.

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