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Biomedical subjects

W G Clements

Publications and source records attributed to W G Clements.

3 recordsLinked to original sources
PubMed1988

Antibodies against monocytes and endothelial cells in the sera of patients with atherosclerotic peripheral arterial disease.

We looked for antibodies against endothelial cells, monocytes, fibroblasts, lymphocytes and Epstein-Barr virus transformed lymphocytes in the sera of 28 elderly and 18 middle-aged patients with atherosclerotic peripheral arterial disease and 13 controls. Inclusion criteria were symptomatic peripheral arterial disease with intermittent claudication and ankle/radial Doppler pressure ratio less than 0.7 in the patient group and greater than 1 in the controls. The sera were tested using a standard cytotoxic technique against a cell panel of monocytes, T and B lymphocytes from 5 donors, and against endothelial cells, fibroblasts and Epstein-Barr virus transformed lymphocytes from one umbilical cord vein and blood. The sera of 30 of 46 (65.2%) patients showed toxicity against monocytes from at least one member of the cell panel and 12 of 19 sera tested (63%) reacted with endothelial cells. Only one of the control sera was positive against monocytes and none reacted with endothelial cells. None of the sera of either patients or controls contained cytotoxic antibodies against T and B lymphocytes, Epstein-Barr virus transformed lymphocytes or fibroblasts. The selective cytotoxicity suggests that the antibodies detected are not against HLA-antigens (which are expressed by normal lymphocytes and Epstein-Barr virus lymphocytes). Our results suggest that immune phenomena occur in atherosclerosis.

Aged↗
PubMed1983

Predictable anterior determinants.

A method has been proposed to develop anterior determinants that are comfortable and pleasing to the patient, who participates in the development of their anterior esthetics and phonetics. This activity encourages final acceptance. Because the teeth are preoperatively restored to their final size and shape, a more conservative preparation results. The resultant provisional restorations provide guidelines for the final ceramometal restorations. The laboratory procedures are also simplified by detailed records and improved communication. The copings are finished to their proper dimension, and it becomes readily evident whether metal lingual surfaces should be provided. The porcelain can be applied in less time since the lingual concavity and incisal edge are "pre-formed." Usually fewer porcelain bakes are required due to uniform compensation for shrinkage. The incisolingual index creates a more positive and accurate form for the proposed restorations because it is mounted directly and securely to the articulator and not hand-positioned. The disadvantage of multiple, early appointments is far outweighed by the quality provided and the reduced time in adjustments. In final analysis this technique is less costly, ensures better esthetics and phonetics within less time, and creates better patient-dentist-technician relationships.

Crowns↗