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Biomedical subjects

W G Hosemann

Publications and source records attributed to W G Hosemann.

3 recordsLinked to original sources

Results of endoscopic surgery of the paranasal sinuses and anterior skull base.

Based on the experience with more than one thousand endoscopical interventions at the paranasal sinuses, a concept of the surgical treatment of chronic sinusitis is presented. According to the individual localization and extent of pathologic changes, appropriate operations may be selected. They follow the principles of conservative surgery. Regeneration of the diseased mucosa is enhanced by the reestablishment of ventilation and drainage instead of its radical removal. The endoscopical postoperative care is mandatory. A follow-up of 90 cases has evidenced a difference between subjective evaluation and endoscopic findings. Patients with bronchial asthma had benefits from their sinus surgery. Endoscopic management of foreign bodies, dural fistulas and benign tumors at the anterior skull base has also proven valuable.

Drainage

ASA-induced release of histamine from nasal mucous membranes in analgesic intolerance and polyposis nasi.

Tissue samples from the polypous mucous membrane and the inferior nasal concha were taken from 13 patients with polyposis nasi and from 12 other patients with an additional intolerance to analgesics. The tissue of the inferior nasal concha from patients without polyposis nasi served as a control. The relative histamine content of the samples (in ng/mg dry weight) and the relative histamine release (in %) after addition of acetylsalicylic acid (ASA) were determined. A significantly higher relative histamine content in the tissue samples of polyp patients without an intolerance to analgesics was seen in comparison to the other two groups. The relative histamine release of both patient groups with nasal polyposis was comparable. The control group exhibited both an increased spontaneous release of histamine as well as a higher relative histamine release from the tissue of the inferior nasal concha.

Adult