Temperature sensitive radio transmitters were implanted into the abdominal cavities of two substrains of pointer dogs to monitor the core temperature during a 12:12 L/D cycle. The results obtained from dogs of a nervous, person-aversive strain were best described by a partially-rectified sine curve, with well defined maxima during the light period. When similarly tested in a situation with minimal diurnal stimulation, the variation in temperatures was reduced. Temperatures of normal pointer dogs, kennel-mates of the nervous dogs, fluctuated very little by comparison. Their data fitted a straight line about as well as a sine curve.

Abdomen↗

PubMed1986

Drug holidays and serum haloperidol levels in schizophrenic patients.

Chronic hospitalized schizophrenic patients receiving haloperidol were placed on drug holidays for 2 days. Serum haloperidol levels in these patients decreased to about 60% of the levels seen just prior to the usual morning dosing during the drug holiday. Control subjects not given a drug holiday showed stable day-to-day serum haloperidol levels. The small drop in serum haloperidol blood levels may relate to the lack of relapse observed in such patients.

Adult↗

PubMed1985

A practical method to enhance fairness of clerkship ratings.

Explore the source record for details and available documents.

Clinical Clerkship↗

PubMed1979

Familial anthropophobia in pointer dogs?

This article assesses a dog model in terms of a proposed cross-species definition of phobia, the model referring to a strain of unstable dogs that has been produced by selection and inbreeding. The unstable dogs are contrasted with a strain of stable dogs. New findings are presented on approach and activity behavior toward three stimulus objects (man, another dog, and a sheet-covered chair) in a naturalistic setting. The fear response of unstable dogs to objects other than man habituates gradually, whereas the fear response to the sight of man is far more enduring, suggesting a relatively specific fear of man.

Animals↗

PubMed1979

A dog model for human psychopathology.

The author reviews studies of the development and scientific exploitation of two true-breeding strains of pointer dogs, one of which is basically normal and one of which is nervous, particularly around people. Basic studies, which generally contrast the nervous dogs with the normal dogs, include studies of inheritance, early experience, conditioning, psychophysiology, neuropharmacology, and neurochemistry. The author suggests that the nervous line is an animal model of human psychopathology and probably of cardiac pathology.

Animals↗

PubMed1974