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Biomedical subjects

W G Wade

Publications and source records attributed to W G Wade.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Taurolin as an oral rinse. I. Antimicrobial effects in vitro and in vivo.

Taurolin, a synthetic antimicrobial agent, has been suggested to be of potential value as an inhibitor of dental plaque. Although data on the antibacterial activity of Taurolin are available there is a dearth of information for effects on oral bacterial isolates and antibacterial activity in the mouth. This study assessed the in vivo and in vitro antibacterial properties of a Taurolin rinse by a) determining the MID values against seven oral isolates and b) measuring salivary bacterial counts following a single rinse. By comparing activity with chlorhexidine, it was hoped to determine substantivity and predict the relative ability of Taurolin to inhibit plaque through an antimicrobial effect. For Taurolin, MID values against the test organisms were found to range between 1:20 and 1:80, while for chlorhexidine, values between 1:320 to 1:640 were obtained. The effects on salivary bacterial counts revealed that Taurolin significantly reduced salivary bacterial counts compared to saline up to 5 hours post rinsing, but was significantly less effective than chlorhexidine after 30 minutes and up to 7 hours. Results indicate that Taurolin has some persistence of antimicrobial activity in the mouth. This suggests that Taurolin would possess some plaque inhibitory properties albeit less than chlorhexidine. These conclusions were confirmed in a subsequent investigation.

Adult↗
PubMedDate not supplied

Taurolin as an oral rinse. II. Effects on in vitro and in vivo plaque regrowth.

A Taurolin solution has been shown previously to possess antibacterial activity, not only by a bactericidal effect but also by reducing bacterial surface adherence. Such mechanisms may contribute to reduction in dental plaque in the mouth, however this remains to be determined. The present study assessed whether a Taurolin rinse could firstly effect bacterial surface growth and, secondly, whether the same rinse could reduce plaque regrowth over a 4-day period. The findings showed that the Taurolin reduced in vitro bacterial surface growth and in vivo plaque regrowth compared to saline, but was not as effective as a chlorhexidine rinse. The findings suggest Taurolin would probably have a moderate effect on plaque and gingivitis in longer-term use.

Analysis of Variance↗
PubMedDate not supplied

Comparison of two commercially available chlorhexidine mouthrinses: I. Staining and antimicrobial effects in vitro.

Several commercially produced chlorhexidine rinses are now available. These formulations vary in concentration and recommended regimens of use. One formulation, a 0.1% chlorhexidine rinse, anecdotally has been reported to not produce the characteristic dental staining. The aim of this study was to compare the 0.1% formulation with a 0.2% commercially produced chlorhexidine rinse for staining and antimicrobial effects in vitro. Tea staining of tooth and acrylic specimens exposed to the two rinses at various dilutions was measured over a 5-day period. Minimum inhibitory dilutions of each product against standard test bacteria were determined by agar dilution. The 0.1% product produced no staining of specimens greater than that noted with controls. At equivalent concentrations, the 0.2% product produced heavy staining of specimens. The antimicrobial effect of the two products was similar but the overall profile for the 0.1% preparation suggested activity derived from ingredients other than chlorhexidine. The results suggest that the chlorhexidine in the 0.1% rinse was partly or completely inactivated and, although staining may not occur in vivo, the formulation would have a much reduced antiplaque action.

Chlorhexidine↗