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Biomedical subjects

W Görke

Publications and source records attributed to W Görke.

18 recordsLinked to original sources
PubMed1991

Non-target visual event-related potentials in evaluation of children with minor head trauma.

In 50 children, 4 months to 12 years of age, with minor head trauma non-target visual event-related potentials were performed and compared to a second registration of the potentials some months later. On following-up there was a clear tendency for a relative improvement of the latencies of the endogenous potentials. In this way non-target visual event-related potentials proved to be of value in the investigation of mental impairment in early childhood.

Brain Diseases↗
PubMed1990

Biochemical and neurophysiological investigations in two forms of Segawa's disease.

In two 14-year-old children with the typical clinical picture of Segawa's syndrome the metabolism of L-DOPA was examined and compared to an age matched control. The very different responses to DOPA- and benser-acid-medication underline the hypothesis, that Segawa's disease may result from at least two different pathological conditions. Since this disease mimics hereditary degenerative nervous tissue disorders, evoked potentials of both patients are demonstrated, showing that those pathways of the CNS, who can be examined by these methods, are unaffected.

Adolescent↗
PubMed1990

[Visual evoked discrimination potentials in childhood].

70 children without visual, developmental or neurological handicap in the age of 3 to 92 months were investigated. Using red and white light flashes non-target event-related evoked potentials have been registrated, white light serving as rare (20%) stimulus (Fig. 1 and 5). It could be shown that in the event-related potential the peak latencies from N3 on had a significantly shorter latency than under red- or pure white-light stimulation (Fig. 2). They were called discriminative potentials. Diagrams (Fig. 4) revealed a maturating course with increasing age by decreasing latencies of the discriminative peaks. Normal values (Table 1) were compiled in order to serve as diagnostic criteria in diagnosis and follow-up of cerebral affections in early childhood.

Aging↗
PubMed1990

[Acoustic evoked discrimination potentials in early childhood].

In 68 children without brain-disease, 3 months to 8 years of age, auditory non-target event-related potentials have been elicited. A 500 Hz-tone of 500 ms duration served as frequent stimulus, while a seldom (20%) and irregularly offered 2000 Hz-tone of the same duration produced the event-related potentials. Comparison between the four kinds of successively recorded potentials (100% 500 Hz, 80% 500 Hz with 20% 2000 Hz, and 100% 2000 Hz) led to the identification of potentials reflecting discrimination of the two sounds, since their latencies significantly differed in the event-related potential from the other three kinds of potentials. Latencies of the peaks in the event-related potentials showed evidence of maturation with increasing age. Normal values with 2.5-sigma border of the latencies of the event-related peaks were compiled bringing about the possibility to use the method in the clinical work-up of children with brain diseases.

Aging↗
PubMed1987

Diagnostic value of somatosensory evoked potentials as compared to neurological score, EEG and CT in infancy--a prospective study.

The present investigation was performed to check, whether additional Med-SEP (somatosensory evoked potentials after stimulation of the median nerve) registration is necessary in the clinical and laboratory work-up in neurologically abnormal infants. For this purpose 28 infants suspected to develop cerebral palsy underwent neurological, neurophysiological and radiological examination at the age of 1 to 10 months. They were prospectively followed-up to their second year of life. On follow-up examination 22 of them showed a pathological development. 12 of them developed cerebral palsy, 7 were moderately to severely retarded, one died of Leigh's disease, one developed Pelizäus Merzbacher disease, and one suffered from Lesch-Nyhan syndrome. Comparison of the findings in infancy and development led to the following conclusion: Med-SEP registration is a valuable contribution in the clinical diagnostic work-up of neurologically abnormal infants. Among 22 children developing neurodevelopmental sequelae there were 2 showing a relatively low neurological score in infancy, 5 having normal EEG records and 4 with normal CT findings, but who could have been identified by Med-SEP alterations alone yet in infancy.

Cerebral Palsy↗
PubMed1986

Peroneal somatosensory evoked potentials in the "pure" form of hereditary spastic paraplegia.

Two patients suffering from the stationary form of hereditary spastic paraplegia, father and son, are described. While in the father the disease - probably because of congenital clubfeet - led to flexion contractures of the hip- and knee-joints, the son in contrary showed extreme genua recurvata. In spite of these contradictionary findings, neurological examination of both patients led to the diagnosis of stationary form of hereditary spastic paraplegia. Both patients had normal latencies of their somatosensory evoked peroneal cortical potentials (Peron-SEP). It is known that the progredient form of the disease leads to alterations of the Peron-SEP. So it is the opinion of the authors that this electrodiagnostic aspect might allow to distinguish between the "pure" and the progredient form of the disease in less clear cases, if these findings can be confirmed in other sibships with the "pure" form of hereditary spastic paraplegia.

Adult↗
PubMed1986

Somatosensory evoked cortical potentials indicating impaired motor development in infancy.

Somatosensory evoked cortical potentials were performed on 120 infants between one and 10 months of age because impaired development was suspected on the basis of their histories or clinical findings. All but two had a follow-up examination after their first birthday. Of the 120 infants, 47 presented with only minor perinatal risks: these had normal neurological and developmental findings in infancy and at follow-up and they formed the control group. 73 infants initially had developmental delay or abnormal neurological findings: at follow-up 35 were normal and 38 had pathological conditions (16 general psychomotor retardation, 15 cerebral palsy, four degenerative and three neurometabolic diseases of the CNS). Marked prolongation of N1 peak latencies (greater than 2ms) above the two-sigma border, or absence of potentials on one or both sides, indicated handicap after their first birthday in all 19 infants showing such alterations. The author concludes that these marked alterations have a high prognostic value.

Developmental Disabilities↗
PubMed1981

The differential diagnosis of congenital analgesia and other diseases with diminished pain perception in childhood. Case report and review.

This paper reports the case of a boy aged 10 months who suffers from congenital analgesia in its pure form. All clinical, biochemical, neuro=physiological and histological data considered to be significant in the differential diagnosis are presented. The findings in all diseases in which impairment of pain sensation occurs are tabulated. 38 patients meet the diagnostic criteria for pure congenital analgesia. The diagnostic criteria are generalized indifference to pain dating from birth; no impairment of other sensory modalities; normal intelligence; normal deep tendon reflexes; no visceral pain perception; normal skin biopsy; no diminution of myelinated or un-myelinated nerve fibres in sural nerve biopsy; normal motor and sensory nerve conduction velocities and normal karyotype. The mode of inheritance remains unclear, but it is assumed, that congenital analgesia might be an autosomal-recessively inherited disease.

Child↗
PubMed1981

[Ulnar nerve-hypothenar muscle H-reflex in a child with SLE (author's transl)].

In the hypothenars of a 14 years old boy with SLE an abnormal H-reflex could be elicited by ulnar nerve stimulation. Beyond infancy this phenomenon has only been described in patients with lesions of the higher cervical spinal cord and/or the lower brain stem and in children with Sydenham's chorea. There might be reason to assume, that in alike auto-immune disorders the search for an H-reflex in the hypothenar might be useful in detection of cerebral involvement.

Adolescent↗
PubMed1977

Fibre type disproportion in the rigid spine syndrome.

An adolescent presented with the clinical symptomatology of the rigid spine syndrome. Whereas an earlier biopsy from the M. erector trunci showed myopathic features and marked endomysial fibrosis, recent findings in the M. biceps consisted of type I-fibre atrophy, type I-fibre predominance, and hypertrophy of type II-fibres. The significance of these findings and possibly a relationship to congenital fibre type disproportion are discussed.

Adolescent↗
PubMedDate not supplied

[Normal latencies of cortical somatosensory evoked potentials--an additional criterion for the diagnosis of Rett syndrome].

In four girls aged from 2 1/2 to 17 years with Rett's syndrome confirmed on the basis of clinical criteria, somatosensorically evoked cortical potentials were led off contralaterally on both sides following stimulation of the median nerve (Med SEP). Like three other children with Rett's syndrome reported by Verma et al. (1987) the present author's patients had normal latency times. Determination of normal latency times for somatosensorically evoked potentials may thus be regarded as an important additional diagnostic criterion for the diagnosis of Rett's syndrome.

Adolescent↗
PubMedDate not supplied

[Apparent central facial paralysis in Lyme borreliosis].

In childhood Lyme-Borreliosis often presents as facial palsy. This progredient infectious disease is to be treated by intravenous penicillin therapy in order to avoid future complications. In three out of four own observations facial palsy raised suspicion towards central origin. By performance of the orbicularis oculi reflex in all four cases peripheral damage of the facial nerve could be demonstrated. This simple electromyographic method seems to be a valuable tool in the differentiation of central and peripheral facial nerve palsy in childhood, preserving the affected children from painful electrodiagnostic procedure or useless search for supranuclear lesions.

Blinking↗
PubMedDate not supplied

[Indications for studying evoked potentials in childhood. Methods--indications--value].

Evoked potentials (EP) represent a valuable addition to currently applied diagnostic methods in neuropediatrics. Profound knowledge of the neurophysiological conditions producing EP-alterations allows basic conclusions, that cannot be gained or replaced by other investigations. EP-investigation demonstrate the existence but not the nature of a lesion in the CNS. Further diagnostic work-up usually will be necessary. Proved EP-alterations produce reproducible diagnostic results and give clues regarding its localization. Evoked potentials can be used as a screening-method for neuropediatric diseases. By follow-up examinations it is possible to show, wether there is progression or not. Testing for evoked potentials is indicated in suspected cerebral palsy in infants, in all cases of psychomotor retardation of unknown origin, impairment of vision or hearing, in cases of brain trauma or in suspected brainstem process, lesions of N. opticus or visual projective systems, neurometabolic or degenerative CNS disease, phacomatosis, progressive myoclonic epilepsy, ceroidlipofuscinosis Jansky-Bielschowski, benign partial epilepsy with extreme somatosensory evoked potentials, Ramsey-Hunt-Syndrome and aplasia of the corpus callosum.

Brain Damage, Chronic↗