[Pindolol eyedrops: does ISA provide more cardiac safety?].
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Biomedical subjects
Publications and source records attributed to W Görlich.
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Beta-adrenergic blocking agents are usually administered in 2 or 3 different concentrations in the treatment of glaucoma. Arguments for varying the dose are dose-dependent decompression, the onset of symptoms similar to tachyphylaxis, and the incidence of systemic side-effects which may be influenced by modification of the dose. The present author's results, however, appear to contradict these arguments; therefore, this paper discusses whether there is any advantage to be gained by administering beta blockers in different concentrations.
Various concentrations of Pindolol eye drops (0.17%, 0.35%, 0.5%, 0.72%, 1.0%), a beta-blocking agent with an intrinsic sympathomimetic activity, were investigated with regard to their pressure-lowering effect in open-angle glaucoma. It was found that all of these concentrations reduce intraocular pressure, but that only the 1% solution has a significantly stronger effect after 24 hours. It is therefore preferable to use this relatively high concentration, especially as it is not accompanied by a bronchopulmonary risk.
Pindolol eye drops were compared with Timolol in a randomized 4-week investigation carried out in patients suffering from open-angle glaucoma. The two drugs were found to have the same pressure-lowering effect. Pindolol has been used in internal medicine for more than 12 years now. It has less influence on airway resistance than Timolol.
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The programmed correction osteotomy is a possibility to correct defective positions of long bones with a determinable exactness by a technical appliance of operation. The appliance, resting on the bone, is leading the saw during the section. The cut surface is arcuate. By this technique it is possible to correct in a raised degree of exactness defective positions of bones in three dimensions with only two sections and without radiological checks or measurements. The programmed correction osteotomy and her stage of development up to now are described.