Large numbers of paracrystalline undulating membranous structures (UMS) were observed in the nuclei of dense cells in a human parosteal osteosarcoma. The electron-dense walls of the structures were 15-20 nm thick, and circular profiles had an outer diameter of 60-70 nm and an inner diameter of 25-30 nm. The UMS-containing cell nuclei displayed a number of other characteristic features, including vermicellar bodies, large numbers of interchromatin granules, and prominent perichromatin granules. The possible significance of these features is discussed.

Adult↗

PubMedDate not supplied

[Diagnostic and therapeutic considerations in aneurysmatic bone cysts of the jaws].

A case of aneurysmatic bone cyst of the mandible is described. Following curettage the condition recurred twice and was then successfully treated with cross-section and primary reconstruction of the mandible. The pathogenesis of aneurysmatic bone cysts and the indications for radical surgical treatment are discussed.

Adolescent↗

PubMedDate not supplied

[Askin tumor. Rare neurogenic tumor with metastasis to mouth, jaw and face regions].

One case of a malignant peripheral neuroectodermal tumor of the thoracopulmonary region (Askin-Tumor) is reported. The tumor represents a distinct pathologic entity of neuroectodermal origin. The patient developed a metastasis in the upper jaw and in a lumbar vertebra. Morphologic and immunocytochemical findings of this extremely rare tumor were described and differential diagnosis from other soft-tissue round-cell sarcomas, such as Ewing's sarcoma and neuroblastoma are discussed. Problems associated with the clinical behavior and treatment are outlined. The prognosis in most cases of Askin-tumor is poor. The recommended therapy is radical resection, irradiation and combination chemotherapy containing anthracyclines and a high dose of alkylating agents.

Diagnosis, Differential↗