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Biomedical subjects

W Günther

Publications and source records attributed to W Günther.

At least 91 records · Page 5Linked to original sources
PubMed1983

[Psychomotor disorders in psychiatric patients as a possible basis for new approaches in differential diagnosis and therapy. I. Results of initial studies in depressed and schizophrenic patients].

Tests that have rarely been used up to now in the psychomotor examination of psychiatric patients have been put together in accordance with our preliminary investigations to form a broader, standardized battery. With this new battery, which consists of the motorische Leistungsserie, a modified version of the Lincoln-Oseretzky motor development scale and the motor subtest of the Luria-Nebraska neuropsychological battery, a study has been carried out on 15 schizophrenics not actually treated with drugs, 15 endogenous and 15 non-endogenous depressed persons and 15 healthy controls. With the results of such a psychomotor "profile", measured over all items, psychotic patients can be clearly separated from the non-endogenous depressed patients and healthy controls. No significant differences have been found between non-endogenous depressed patients and healthy controls. These results are basically in agreement with many single findings in the literature. Results based on a broader battery for the investigation of psychomotor abilities in psychiatric patients could be of value in difficult differential-diagnostic problems and ought therefore to be studied further. In addition, the movement disturbances in psychotic patients, which have been measured by a broader standardized battery, could be the starting point in the development of specific psychomotor training programmes, which could improve the efficiency of conventional gymnastic and ergotherapeutic treatment methods. In this direction too, further studies would be useful and are indicated.

Adult↗
PubMed1982

Polyclonal B cell activation in the acute phase of systemic lupus erythematosus--aspects of pathogenic significance.

B lymphocytes from patients suffering from systemic lupus erythematosus show increasing rates of spontaneous transformation in prolonged cultivation (144 hr). An additional B cell stimulation could be detected following the addition of sera from lupus erythematosus patients (isolated during the acute phase of disease) to the culture medium. In addition enriched mitogenic serum components from lupus sera increase the 3H-thymidine uptake of Brucella abortus primed B cells of healthy controls. The incorporation of 3H-thymidine with respect to the Brucella antigen concentration is described.

B-Lymphocytes↗
PubMed1982

[The use of tramadol-HCl (Tramal) as adjuvant in regional anaesthesia. Clinical report (author's transl)].

The report deals with the clinical use and effects of tramadol-HCl (Tramal) as an adjuvant in regional anaesthesia. As distinguished from triflupromazine, diazepam, flunitrazepam, droperidol, piritramide and pentazocine this drug can be applied safely, reliably and without secondary effects in patients of all ages for sedation and analgesia without loss of cooperation (no sleep, no pain from body-positioning, no psychic distress) and for the prevention of centralisation in the unblocked region (no trembling- and freezing-reaction, no alteration of the blood-gas-analysis.

Anesthesia, Conduction↗
PubMed1979

[Psoriasis vulgaris: immunologlobulin binding to human epidermis after limited proteolysis].

Immune complexes isolated from sera of psoriatic patients and healthy controls show an identical pattern in sodiumdodecylsulfate polyacrylamide gel electrophoresis. And so it seems to be unlikely that the increased provable serum immune complexes by psoriatics contain specific protein antigens.--Following to limited proteolysis of normal human epidermis, antibodies which solely are provable in sera of psoriatic patients could bind to proteolytic altered structures. For achieving a similar process in vivo, the following conditions are to be discussed: (1) an elevated concentration of certain autoantibodies in the sera of psoriatic patients and a temporary increased vessels permeability for antibodies, (2) the availability of structures in the epidermis of psoriatics with increased affintiy to certain antibodies. These structures may be produced by limited proteolysis or as a result of the disturbed differentiation of epidermal cells.

Antigen-Antibody Complex↗
PubMed1979

[New studies on the pathogenesis of lupus erythematosus].

The pathogenesis of the lupus erythematosus results from co-operation of three principles: (1) genetical disposition, (2) increased reactivity of the immune system, (3) different exogenic influences. The genetical disposition is confirmed by family investigations, metabolic disorders and immune anomalies as well as by parallels to animal models. The reaction manner of the immune system is genetically determined. Exogenic factors influence the immune system (behaviour) either as starter or by modifying the genetical material. The most striking humoral immune phenomenon is an immense number of (auto-)antibodies. Investigations of xeroderma pigmentosum as well as with DNA of different antigenity have shown that an increase of the antigenicity is unlikely for this phenomenon. In the serum of patients there were established and partially characterized factors (mitogens, granulocytic adherence-factor) for increasing the immune reactivity. The increase of such factors may be the sequence of a T-suppressor cell-defect. Like-wise no interdigitating cells in systemic lupus erythematosus have been found, cells which may be responsible for the terminal differentiation of T-lymphocytes. The mode of action of exogenic factors is represented and discussed with the example of the UV provocation.

Antibodies↗
PubMed1977

Relation of lipoprotein lipase activity in adipose tissue to adipocyte volume and its influence in hypertriglyceridemia pathogenesis.

In the subcutaneous adipose tissue of 20 normal weight and overweight subjects with normo- or hypertriglyceridemia, the relation is examined between the lipoprotein lipase activity (LPLA) per gram adipose tissue and adipocyte volume. The following findings were obtained: 1. Significant positive correlations between the LPLA per gram adipose tissue and the adipocyte volume were ascertained in the groups of subjects having normal triglyceridemia or exhibiting hypertriglyceridemia. 2. The negative relation between the LPLA in the adipose tissue and the triglyceride level in serum described in literature could not be verified. Across a glyceride span of 76 to 600 mg% in serum we found a correlation coefficient of +0.34. 3. It can therefore be assumed that the LPLA per gram adipose tissue with increasing adipocyte volume does not represent an inhibiting factor to the triglyceride in serum breakdown in the development of hypertriglyceridemia.

Adipose Tissue↗