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Biomedical subjects

W GARSON

Publications and source records attributed to W GARSON.

At least 19 recordsLinked to original sources
PubMed1961

Surveillance studies on Neisseria gonorrhoea sensitivity to penicillin and nine other antibiotics.

As increasing numbers of gonococcal strains obtained in routine isolations from patients show reduced sensitivity to penicillin and as more and more patients report that they are allergic to penicillin, other antibiotics are being increasingly frequently resorted to in the treatment of gonorrhoea. It is therefore of importance to determine the susceptibility of both penicillin-sensitive and relatively "resistant" strains to these other chemotherapeutic agents.The authors report on a study of the in vitro action of the following antibiotics against routine gonococcal isolates and strains from gonorrhoea cases in which penicillin had failed to effect a cure: kanamycin, leucomycin, chloramphenicol, dextrosulphenidol, oxytetracycline, chlortetracycline, tetracycline, demethylchlortetracycline and synnematin B. It was found that strains of low penicillin susceptibility were as sensitive to these antibiotics-with the exception of synnematin B-as were those of high penicillin sensitivity.Emphasis is placed on the need for establishing an international standard procedure for gonococcal sensitivity testing which would make it possible-as it is often not at present-to compare results obtained in different laboratories. The relation between response to treatment and the degree to which patients develop blood and tissue concentrations of penicillin is also discussed.

Anti-Bacterial Agents↗
PubMed1959

Facts and fallacies about gonorrhea and syphilis.

The limitations and special usefulness of clinical and laboratory diagnostic techniques in the diagnosis of gonorrhea are poorly understood and utilized by the average practitioner today. Most physicians and clinics, lulled by complacency or lack of ancillary aid in the area of diagnosis, proceed by measures based in many instances upon past fallacy rather than upon the facts recently developed by research in this disease. The same circumstances apply concerning treatment and management of this disease, particularly in females. All physicians are potentially capable of giving excellent treatment for syphilis today. The problem is to properly diagnose the disease, manage the patient and deal with the source. Looming large in the area of diagnosis is the interpretation of serologic tests for syphilis. No serologic test diagnoses syphilis, but rather gives information as to the immunologic status of the the patient in relation to reagin and treponemal antibodies. None of the antibodies measured in these tests are absolutely specific for syphilis alone. There is no substitute for a well-informed physician, who knows his patient, to relate and interpret even the best of treponemal serologic tests.

Female↗