Biomedical subjects
Publications and source records attributed to W Gay.
Clear differences in the attitudes of 1,226 adults in a Gallup survey and 130 patients in 4 methadone treatment programs were observed. Patients were more permissive on legalization of use of and education about drugs than the adult sample.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
In a patient with myasthenic syndrome neuro-muscular transmission was characterised by depression and facilitation. The relative extent of these two processes varied between muscles, and in the one muscle with time. Guanidine HCl treatment corrected the electrophysiological defect. Oral choline increased muscle action potential amplitude in response to single shocks. Intravenous choline produced features indicating cholinergic autonomic stimulation. Pimozide and plasmapheresis had no effect. Animal in-vivo and in-vitro studies performed to detect a circulating factor which interferes with neuro-muscular transmission were negative.
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A patient with variant angina pectoris due to a pedunculated calcific mass extending from the aortic valve and resulting in intermittent obstruction of the left coronary ostia is reported. No atherosclerotic disease was demonstrated by coronary angiography. During attacks, marked ST segment elevation and episodes of tachycardia were associated with a moderate rise in pulmonary artery pressure. Replacement of the calcified aortic valve resulted in total relief of symptomatology.
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A retrospective study was performed on 65 patients with intractable angina and subtotal coronary occlusions undergoing aortocoronary artery bypass (ACB) to determine whether the local occlusion (L.O.) or the ischemic arrest (I.A.) technique was perferable in performing the distal coronary artery bypass. In 23 patients who had the method of local occlusion, a 45.7 percent incidence of myocardial injury was observed, compared to 42 patients undergoing ACB with ischemic arrest in whom an incidence of 22.5 percent occurred. Both serum glutamic oxaloacetic transaminase (SGOT) and creatine phosphokinase activity (CPK) determinations at 24 hours following operation in those patients not demonstrating evidence of postoperative injury were statistically higher in the local occlusion group compared to the ischemic arrest group. In the L.O. group SGOT was 155 I.U. compared to 77 I.U. in the I.A. group (p less than 0.01). CPK was 72 I.U. in the L.O. groupcompared to 34 I.U. in the I.A. group (p less than 0.05). These data suggest that, in subtotal coronary artery obstruction, the use of the L.O. technique is associated with a higher incidence of myocardial injury than is the technique of total cardiac I.A.
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