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Biomedical subjects

W Gehlen

Publications and source records attributed to W Gehlen.

12 recordsLinked to original sources
PubMed1992

Immunoreactive leukotriene C4 levels in CSF of MS patients.

Using a sensitive and specific radioimmunoassay levels of leukotriene (LT)C4-like material were estimated in lumbar cerebrospinal fluid (CSF) samples from patients with multiple sclerosis (MS) in comparison to control patients with or without inflammatory processes in the central nervous system (CNS). Levels of LTC4-like material were significantly elevated (p less than 0.01) in CSF from patients with inflammatory diseases such as meningitis, polyradiculitis or meningoencephalitis (57 +/- 53 pg/ml, n = 16) as compared to those from control patients without inflammatory or immunological CNS diseases (21 +/- 16 pg/ml, n = 42). By contrast, LTC4-like material was 16 +/- 7 pg/ml in first manifestations of MS (n = 7). 21 +/- 16 pg/ml in remitting-relapsing MS (n = 15) and 10 +/- 6 pg/ml in chronic progressive MS (n = 8). These results argue against a significant pathophysiological role of cysteinyl-LT in MS.

Adult↗
PubMed1979

[Quantitative measurement of muscle tone in patients with Parkinsonism before and during therapy with madopar (author's transl)].

Muscle tone at rest and during passive movement was measured in 13 patients with Parkinsonism before and during Madopar therapy. We used the method of kommutative therapy with additional therapy. Data were obtained by myointegration using surface electrodes on the musc. biceps brachii. As already communicated earlier for measurements during passive movements, we could now also state a significant decrease of rigidity at rest during therapy with Madopar. The rigidity improved by 77,5% after an average duration of treatment of 6,25 months and by 84,8% after 25,7 months. There was a proportional dependence between the degree of rigidity at rest and rigidity during passive movements before therapy. Beyond that the decrease for both types of rigidity was approximately similar during therapy. Furthermore possible pathophysiological sources and correlations of alterations of muscle tone in man are discussed.

Carboxy-Lyases↗
PubMed1978

[EMG-findings in typ-II-glycogenosis (Pompe's disease, acid maltase deficiency) (author's transl)].

EMG findings of two patients (one 43 years old male; one 47 years old female) with Typ-II-glycogenosis are referred. The diagnosis is proofed by enzym histochemical, ultrastructural and biochemical investigations. The EMG findings were characterized by vivacious spontaneous activity and the high rate of different EMG pattern in one patient. Beside myopathic patterns existed neurogenic patterns and spontaneous activities as pseudomyotonic discharges, fibrillations and positive sharp-waves. Case I showed myotonic discharges too. These EMG findings are compared with the histological findings. Signs of differentiation between myotonic and pseudomyotonic discharges especially in view of Typ II glycogenosis is discussed. The EMG findings of the two investigated patients are compared with others of the literature.

Adult↗
PubMed1977

[Analysis of chronic psychotic states in young drug-addicts (author's transl)].

60 young drug-addicts with prolonged psychotic states have been examined. Taking account of the family situation and psychosocial development, of typical timing and drug-specific factors the psychopathologic picture is described as to its course and the multiple effects of drugs. An existing psychosis may be the motive for drug-taking in special ways. On the other hand there is with many patients a coincidence in time between drug-addiction and manifestation of the psychosis. Psychoses independent from drugs i.e. running their own specific course, are seen remarkably often. They cannot be distinguished phenomenologically from endogenous psychoses and end up quite often in a number of defects.

Adolescent↗
PubMed1976

[Differential diagnosis and syndrome-genetic problems and aspects of drug-induced psychoses in juveniles (author's transl)].

Acute and chronic psychotic states in juvenile drug addicts demand careful observation of syndrome-genetic and differential diagnostic factors. Not only the diagnosis of a schizophrenic or affective juvenile psychosis and their differentiation from phase-specific developmental crises may often be difficult. A further problematic field are special aspects of symptomatic psychoses and particularly states due to drug addiction with hashish, LSD and amphetamines and the effect of drugs on already existing endogenous psychoses. This demands subtile phenomenologic description and syndrome-genetic assessment. One will have to take into account the complexity of drug effects and whether a psychosis existed already before addiction, whether drugs have provoked a latent psychosis, whether a purely symptomatic psychosis mimics a schizophrenia or whether irreversible personality changes with secondary psychotic behavior have developed.

Acute Disease↗
PubMed1975

[Methods for recording and quantitative measurement of rigidity and spasticity (author's transl)].

First pathophysiological aspects of rigidity and spasticity are described with special regard to the possibilities of errors during the measurement of muscle tone in man. The following methods are explained and discussed: Psychometric techniques, physical analysis of movements (kinesiology, photobadismography, kinetometry), pendulousness tests, investigations of reflexes (T-reflex, H-reflex, H/M-ratio), electromyographic methods (after-activity, silent period, unloading-reflex, stretch-reflex, release-phaenomen), and torque measurements. In the main we discussed these techniques with the view-point of diagnosis and drug effects. Furthermore we expressed our opinion on the relevance of the different methods. Last the most important sources of errors are tabulated.

Electromyography↗
PubMed1975

[Schizophrenic defect syndromes and drive behavior].

First the terms "impulse" (Antrieb) and "schizophrenic defect" (schizophrener Defekt) are explained and defined. 49 (= 12 per cent) of the 409 schizophrenic in-patients, treated 1970-1972, had the symptoms of a schizophrenic defect. All of them showed disturbances of impulse: more than half the patients a deficiency, nearly a third an unsettled surplus, and about ten percent an alternating impulse. The deficiency as the alternating impulse usually were accompanied with a negativ mood. The surplus of impulse was bound up as equal parts with positive and negative moods. At last any kind of disturbances of described is illustrated by an example.

Adult↗