Segmental neurofibromatosis with ipsilateral renal agenesis.
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Cafe-au-Lait Spots↗
Biomedical subjects
W Gerstein
Publications and source records attributed to W Gerstein.
Resolution of chlorpromazine-induced pigmentation with haloperidol substitution.
Four patients with chlorpromazine-induced pigmentation showed resolution of the condition on replacing chlorpromazine with haloperidol.
Adult↗
Congenital leukonychia striata.
Leukonychia striata of a unique appearance and distribution is described in a 51-year-old woman. Histopathologic examination of a specimen from the nail plate revealed a transverse band of parakeratosis on the ventral surface. Disturbance in keratinization on the nail plate is presumed to be secondary to abnormalities in the nail matrix. We review briefly the classification and pathogenesis of leukonychia, an interesting aberration in nail plate keratinization.
Female↗
Painful and nonpainful piezogenic pedal papules.
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Adult↗
Cell proliferation in human fetal epidermis.
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Autoradiography↗
A mouse model for delayed-type hypersensitivity skin changes in chronic renal failure.
Cellular immunity in mice with chronic renal failure was assessed by delayed-type hypersensitivity (DTH) skin testing. Normal, sham-operated, and C57BL/6 mice with chronic renal failure were sensitized and challenged with oxazolone, a contact-sensitizing agent. The magnitude of the DTH response was determined by sequential measurements of ear thickness following local challenge. Consistently lower DTH responses were observed in mice with chronic renal failure. DTH responses in mice with renal failure were highest at 48 hr postchallenge (9.3 +/- 1.3) but still significantly lower (p less than 0.05) than those in both sham-operated (12.9 +/- 0.7) and normal mice (12.6 +/- 1.0). When compared with those of the other groups, DTH responses of sham-operated animals were brisker (24 hr), while those of normal mice were more sustained (72 hr). These results confirm previously reported observations in end-stage renal disease patients. The mouse, along with appropriate skin testing, appears to be a useful model for studying cellular immunity in chronic renal failure.
Animals↗